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Papers
61,005 resultsShowing papers similar to Far-field super-resolution chemical microscopy
ClearHigh-speed scanless entire bandwidth mid-infrared chemical imaging
Researchers developed a high-speed mid-infrared chemical imaging technique using ultrafast laser pulses that can capture a full spectrum image in 8 seconds across a wide chemical fingerprint range — far faster than existing methods. This advance enables rapid identification of different materials in complex samples like microfluidic devices, plant cells, and biological tissue, with strong potential for detecting chemical pollutants including microplastics.
Single-Particle Resolution Fluorescence Microscopy of Nanoplastics
Researchers developed a super-resolution fluorescence microscopy technique that enables single-particle detection and precise localization of nanoplastics in biological tissues and environmental samples. This advancement addresses a major limitation in nanoplastic research, as conventional microscopy lacks the resolution to distinguish individual nanoplastics from background fluorescence or free dye.
Synchrotron-based Spectromicroscopy for Microplastic Detection and Characterization
Researchers reviewed how synchrotron-based imaging techniques — which use powerful X-ray beams to see extremely fine details — can detect and chemically identify micro- and nanoplastics that conventional methods miss, including plastics absorbed into biological tissues. These high-resolution tools are still in early stages but show strong potential for mapping microplastic contamination at the nanoscale.
Photo induced force microscopy: chemical spectroscopy beyond the diffraction limit
This review examines photo-induced force microscopy as an approach for near-field chemical spectroscopy, synthesizing advances in using electromagnetic radiation to interrogate surface properties at nanometre spatial resolution beyond the optical diffraction limit.
3D differential interference contrast microscopy using polarisation‐sensitive tomographic diffraction microscopy
Researchers developed a 3D differential interference contrast microscopy technique using tomographic diffraction microscopy to image unlabeled biological and environmental samples at high resolution — with applications for visualizing microplastics in cells and tissues.
Fast detection and 3D imaging of nanoplastics and microplastics by stimulated Raman scattering microscopy
Researchers developed a fast imaging technique using stimulated Raman scattering microscopy to detect and create 3D maps of nanoplastics and microplastics at the single-particle level. The method can identify plastic particles as small as 100 nanometers and distinguish between different polymer types without the need for dyes or labels. This technology could help scientists more accurately track tiny plastic particles in environmental and biological samples.
Super-resolution imaging of micro- and nanoplastics using confocal Raman with Gaussian surface fitting and deconvolution
Researchers used confocal Raman imaging with Gaussian surface fitting to achieve super-resolution visualization of micro- and nanoplastics beyond the optical diffraction limit, enabling identification and imaging of nanoplastic particles smaller than conventional Raman microscopy can resolve.
Raman spectroscopy as the quantum eye to reveal molecular dynamics in biology
Researchers reviewed advances in Raman spectroscopy — a technique that identifies chemicals by how they scatter laser light — highlighting how recent innovations in surface-enhanced and stimulated Raman methods have expanded its applications in cell imaging, disease diagnosis, drug development, and microplastic detection.
Single particle-resolution fluorescence microscopy of nanoplastics
Researchers developed a fluorescence microscopy technique capable of imaging and identifying individual nanoplastic particles. The method enables single-particle resolution detection of nanoplastics, which is a key step toward better quantifying these otherwise invisible particles in environmental samples.
Dark-field/hyperspectral microscopy for detecting nanoscale particles in environmental nanotoxicology research
Researchers reviewed enhanced dark-field microscopy combined with hyperspectral imaging as a non-destructive optical technique for detecting and chemically characterizing nanoscale particles — including nanoplastics — in live, wet biological samples where electron microscopy is impractical.
Broadband background-free stimulated Raman scattering microspectroscopy with a novel frequency modulation scheme
Researchers developed broadband background-free stimulated Raman scattering microspectroscopy using a novel laser system, enabling chemical imaging without the fluorescence background that limits conventional Raman measurements. The technique offers improved sensitivity for detecting microplastics and other materials in complex biological samples.
In vivo super-resolution of the brain – How to visualize the hidden nanoplasticity?
Researchers reviewed how super-resolution fluorescence microscopy techniques — which allow scientists to image structures smaller than what conventional light microscopes can resolve — are being used to study the nanoscale structure and plasticity of brain synapses in living mice. These imaging advances help reveal how tiny changes in brain connections relate to learning and memory, using "nanoplasticity" in its neurological sense rather than as a reference to plastic pollution.
Fast Detection and Classification of Microplastics by a Wide-Field Fourier Transform Raman Microscope
Researchers developed a new wide-field Raman microscope that can rapidly detect and identify microplastic particles with high spatial and chemical accuracy. The instrument can image a large sample area in about 15 minutes and identify particles down to roughly one micrometer in size. The technology was validated on microplastics from seawater and biological samples, offering a faster alternative to existing detection methods.
Identification and visualisation of microplastics/nanoplastics by Raman imaging (i): Down to 100 nm
Researchers developed an advanced Raman imaging technique capable of identifying and visualizing nanoplastics down to 100 nanometers in size. The study addressed a key analytical gap, as nanoplastic research has been limited by the lack of effective characterization methods, and the new approach offers a way to detect these extremely small particles that may pose greater environmental risks due to their high surface area.
Super-resolution Raman imaging towards visualisation of nanoplastics
Super-resolution Raman imaging was evaluated as a method to visualize nanoplastics smaller than the conventional diffraction-limited laser spot size, overcoming a key barrier in nanoplastic characterization. The technique extends confocal Raman capabilities into the nanoscale detection range needed for environmental nanoplastic analysis.
Infrared spectroscopic laser scanning confocal microscopy for whole-slide chemical imaging
Scientists developed a new infrared microscope that can create chemical images of entire tissue slides in about 3 minutes, far faster than existing methods. While not directly about microplastics, this type of imaging technology could significantly speed up the detection and identification of microplastic particles in human tissue samples. Faster, more detailed chemical imaging tools are needed to better understand where microplastics accumulate in the body and what damage they cause.
Photoinduced Force Microscopy as an Efficient Method Towards the Detection of Nanoplastics
Researchers demonstrated photoinduced force microscopy as an effective method for detecting and chemically characterizing individual nanoplastic particles, overcoming limitations of conventional techniques that lack either sufficient spatial resolution or spectroscopic capability at the nanoscale.
High-resolution characterization technology for micro-/nano-plastics
This review provides an overview of advanced technologies for detecting and characterizing micro- and nanoplastics, including Raman spectroscopy, infrared imaging, and mass spectrometry techniques. Researchers evaluated the capabilities and limitations of each method, particularly for identifying the smallest plastic particles that are most challenging to measure. The study emphasizes that improving detection at the nanoscale is essential for accurately assessing the environmental and health risks of plastic pollution.
Advanced Optical Imaging Technologies for Microplastics Identification: Progress and Challenges
This review surveys advanced optical imaging technologies used to identify microplastics and nanoplastics in environmental samples. Researchers compared techniques like Raman spectroscopy, infrared imaging, and fluorescence microscopy, noting their strengths and limitations for detecting increasingly small particles. The study highlights that improving detection methods is essential for accurately monitoring the full scope of plastic pollution.
Hyperspectral oblique plane microscopy enables spontaneous, label-free imaging of biological dynamic processes in live animals
Researchers developed a new high-speed Raman imaging microscope that can capture label-free, molecular-level images of biological processes in living animals. They demonstrated the technology by tracking microplastic accumulation in the organs of live zebrafish, visualizing particle distribution without any dyes or markers. This imaging advancement could significantly improve how scientists study microplastic uptake and distribution in living organisms.
Identification and visualisation of microplastics/ nanoplastics by Raman imaging (ii): Smaller than the diffraction limit of laser?
Researchers examined whether confocal Raman microscopy can identify and visualize nanoplastics smaller than the diffraction limit of the laser, analyzing the lateral intensity distribution of Raman signals from nanoplastics ranging from approximately 30 to 600 nm in diameter. The study found that while imaging resolution is limited by diffraction, chemical identification of sub-diffraction-limit nanoplastics remains possible.
Real-time detection of label-free submicron-sized plastics using flow-channeled differential interference contrast microscopy
Researchers developed differential interference contrast microscopy for real-time label-free detection of submicron plastics in water, overcoming bright-field microscopy limits.
An aberration-free line scan confocal Raman imager and type classification and distribution detection of microplastics
Researchers developed an advanced Raman imaging system that can identify and classify microplastics as small as 1 micrometer in diameter with 98% accuracy, working about 100 times faster than traditional methods. The system can also detect harmful chemical residues like phthalate plasticizers on microplastic surfaces. Faster and more accurate detection tools like this are essential for understanding the full scope of microplastic contamination in food and water and its potential impact on human health.
Raman Spectroscopic Imaging of Human Bladder Resectates towards Intraoperative Cancer Assessment
Researchers used Raman spectroscopy imaging to distinguish between healthy and cancerous human bladder tissue without the need for chemical stains or labels. The technique successfully identified cancer regions in tissue samples from ten patients, using advanced data analysis to map molecular differences. While not directly related to microplastics, this spectroscopy method is also used in microplastic research and demonstrates the power of label-free chemical imaging in medical applications.