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Papers
20 resultsShowing papers similar to Maltol has anti-cancer effects via modulating PD-L1 signaling pathway in B16F10 cells
ClearUncovering the Anticancer Potential of Polydatin: A Mechanistic Insight
This review examines the anticancer mechanisms of polydatin, a natural stilbenoid compound, detailing its ability to inhibit tumor growth through antioxidant, anti-inflammatory, and apoptotic pathways across multiple cancer types.
The Essential Oil from Conyza bonariensis (L.) Cronquist (Asteraceae) Exerts an In Vitro Antimelanoma Effect by Inducing Apoptosis and Modulating the MAPKs, NF-κB, and PKB/AKT Signaling Pathways
Researchers investigated the anticancer potential of an essential oil extracted from Conyza bonariensis against melanoma cells in laboratory experiments. They found that the oil's major compound interacted with key signaling pathways involved in cell survival and induced programmed cell death in melanoma cells. The study suggests this plant-derived compound may warrant further investigation as a potential source of anti-melanoma agents.
Integration of transcriptomics and metabolomics reveals the mechanism of Lycium barbarum polysaccharides inhibited MCF-7 cell proliferation
Researchers used transcriptomics and metabolomics to investigate how Lycium barbarum polysaccharides inhibit MCF-7 breast cancer cell proliferation, identifying the molecular mechanisms and signaling pathways responsible for the compound's anticancer activity at an optimal dose of 8 mg/mL.
Reversing the immunosuppressive microenvironment with reduced redox level by microwave-chemo-immunostimulant Ce–Mn MOF for improved immunotherapy
Researchers developed a nanoparticle-based treatment that combines microwave energy, chemotherapy, and immune activation to reverse the protective environment that tumors create to hide from the immune system. In animal experiments, this combined approach significantly increased immune cell infiltration into tumors and improved the body's ability to fight cancer beyond the treated area.
Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS
Researchers found that combining melatonin (a natural hormone) with erastin (a cell-death inducer) produced synergistic anticancer effects in oral cancer cells by triggering multiple forms of cell death simultaneously, suggesting a potentially safer and more effective treatment strategy.
Immunotherapeutic strategy in the management of gastric cancer: molecular profiles, current practice, and ongoing trials
This review summarizes immunotherapy strategies for gastric cancer, focusing on PD-L1 expression and immune checkpoint inhibitors (ICIs). Accumulating evidence suggests that targeting the immune response, particularly through ICIs, may improve clinical outcomes in patients with gastric cancer.
Tempol Attenuates Methotrexate-Induced Osteotoxicity via Antioxidant Mechanisms: Impairment of Protection by GPX4 Inhibition Through ML210
Researchers investigated the antioxidant compound Tempol as a protective agent against methotrexate-induced bone cell toxicity in murine osteocytes, finding it effectively reversed apoptosis and oxidative stress markers, but that its protective effects were significantly undermined when the GPX4 antioxidant enzyme was inhibited.
Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma
Researchers found that a protein called SLC7A11, stabilized by the cancer-driving protein EGFR, blocks cancer cells from being recognized and destroyed by the immune system in nasopharyngeal carcinoma, and showed that the drug sorafenib can reverse this immune evasion by targeting SLC7A11.
Anti-diabetic effect of anthocyanin cyanidin-3-O-glucoside: data from insulin resistant hepatocyte and diabetic mouse
Researchers showed that cyanidin-3-O-glucoside (C3G) — a natural pigment found in blueberries and other dark fruits — can improve insulin sensitivity in both liver cell cultures and diabetic mice by suppressing a protein that blocks insulin signaling. The findings suggest C3G could be a dietary strategy for managing type 2 diabetes.
A review on health benefits of marine based neutraceuticals on pancreatic cancer
This review examined health benefits of marine-based nutraceuticals for pancreatic cancer prevention and treatment, finding that bioactive compounds from marine organisms show anti-inflammatory, antioxidant, and antitumor properties with potential to complement therapies for this highly treatment-resistant malignancy.
Quercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells
Researchers found that quercetin, a natural plant compound, protected mouse ovaries from chemotherapy-induced damage by reducing harmful oxidative stress in mitochondria and suppressing a form of inflammatory cell death called pyroptosis, suggesting it could help preserve fertility in patients undergoing cancer treatment.
Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity
This review examines how nanotechnology-based approaches can regulate lipid metabolism in tumor microenvironments to enhance anti-cancer immune responses, covering lipid nanoparticles, liposomes, and other delivery systems. The authors identify lipid metabolic reprogramming as a promising immunotherapy target and nanotechnology as a key enabler for delivering therapeutics that reshape tumor-associated metabolic pathways.
Iron Oxide Nanoparticles: Selectively Targeting Melanoma Cells In Vitro by Inducing DNA Damage via H2AX Phosphorylation and Hindering Proliferation through ERK Dephosphorylation
Researchers investigated iron oxide magnetic nanoparticles and found they selectively target melanoma cancer cells while sparing healthy skin cells. The nanoparticles triggered DNA damage and blocked cell growth signals specifically in melanoma cells, and their effectiveness was further enhanced using magnetic heating. The study explores a nanotechnology-based approach to cancer treatment rather than microplastic-related research.
Santacruzamate A Alleviates Pain and Pain-Related Adverse Emotions through the Inhibition of Microglial Activation in the Anterior Cingulate Cortex
Researchers found that Santacruzamate A, a natural compound from marine cyanobacteria, reduced chronic pain and pain-related anxiety in mice by calming overactive immune cells in the brain. The compound works by inhibiting an enzyme involved in inflammation, which in turn reduces levels of inflammatory signals. The study suggests this marine-derived compound could be a candidate for developing new pain treatments.
Avaliação do efeito de citotoxicidade dos microplásticos na linhagem mamária humana MCF10A
Researchers assessed the cytotoxicity of microplastics on the non-tumoral human breast cell line MCF10A and explored whether the antioxidant resveratrol could mitigate those effects. The study found that microplastics negatively impacted cell viability and that resveratrol showed potential as a protective agent in the cellular context of MP exposure.
Nanoplastic-Induced Liver Damage Was Alleviated by Maltol via Enhancing Autophagic Flow: An In Vivo and In Vitro Study
Researchers found that nanoplastic exposure caused liver damage in mice through oxidative stress, cell death, and impaired cellular recycling processes. They then tested maltol, a compound derived from red ginseng, and found it significantly reduced the liver damage by restoring healthy autophagy and reducing oxidative stress. The study suggests that natural compounds like maltol could potentially help protect the liver from the harmful effects of nanoplastic accumulation.
CHEMOPREVENTIVE POTENTIAL OF ALCOHOLIC EXTRACT OF A POLYHERBAL ( Phyllanthus amarus, Euphorbia hirta and Azadirachta indica) RECIPE AGAINST BENZO(a)PYRENE INDUCED LUNG CARCINOGENESIS IN ALBINO MICE
Researchers assessed the chemopreventive potential of an alcoholic extract of a polyherbal preparation including Phyllanthus amarus in a precancerous lesion model, measuring effects on biomarkers of oxidative stress and inflammation. The herbal extract reduced key biomarkers compared to untreated controls, supporting further investigation of plant-derived compounds as adjuncts in cancer chemoprevention.
Ursolic Acid Suppresses Proliferation and Elicits Apoptosis of Laryngeal Carcinoma Cell HEp-2 through Activation of ROS Synthesis and Inhibition of Multiple Signaling Pathways
Researchers investigated the anticancer effects of ursolic acid on laryngeal squamous cell carcinoma HEp-2 cells, finding that it suppressed proliferation and induced apoptosis by stimulating reactive oxygen species (ROS) synthesis. The ROS increase was linked to activation of MAPK, PI3K/Akt, NF-κB, and STAT3 signaling pathways, positioning ursolic acid as a potential phytochemical therapeutic candidate for laryngeal carcinoma.
Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells
Researchers found that oridonin, a natural plant compound, can trigger two different types of cell death simultaneously in bone cancer cells. This dual mechanism makes it effective at suppressing tumor growth in osteosarcoma. The study suggests oridonin could be a promising therapeutic agent for treating this type of bone cancer.
Glyceroglycolipids in marine algae: A review of their pharmacological activity
This review examines the pharmacological activities of glyceroglycolipids from marine algae, highlighting their anti-inflammatory, antioxidant, antiviral, and antitumor properties and their potential applications in medicine and cosmetics.