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Article
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Tier 2
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Original research — experimental, observational, or case-control study. Direct primary evidence.
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Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS
Cellular & Molecular Biology Letters
2023
58 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 50
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0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Leilei Wang,
Chuan Wang,
Xuan Li,
Yu‐Xiong Su,
Zhuo-Ying Tao,
Zhuo-Ying Tao,
Wangyong Zhu,
Wangyong Zhu,
Yu‐Xiong Su,
Wing Shan Choi
Summary
Researchers found that combining melatonin (a natural hormone) with erastin (a cell-death inducer) produced synergistic anticancer effects in oral cancer cells by triggering multiple forms of cell death simultaneously, suggesting a potentially safer and more effective treatment strategy.
Melatonin combined with erastin exhibits synergistic anticancer effects without adverse reactions. Herein, this combination might become a promising alternative strategy for oral cancer treatment.
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