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Anti-diabetic effect of anthocyanin cyanidin-3-O-glucoside: data from insulin resistant hepatocyte and diabetic mouse

Nutrition and Diabetes 2024 39 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Wen Chen, Wen Chen, Wen Chen, Xiang Ye, Wen Chen, Xu-Fan Huang, Xiang Ye, Xu-Fan Huang, Fujie Yan, Fujie Yan, Fujie Yan, Shuiguang Deng, Xiaodong Zheng Peng‐Fei Shan, Fujie Yan, Xiaodong Zheng

Summary

Researchers showed that cyanidin-3-O-glucoside (C3G) — a natural pigment found in blueberries and other dark fruits — can improve insulin sensitivity in both liver cell cultures and diabetic mice by suppressing a protein that blocks insulin signaling. The findings suggest C3G could be a dietary strategy for managing type 2 diabetes.

These findings demonstrated that C3G could alleviate IR in vitro and in vivo to increase insulin sensitivity, which may offer a new insight for regulating glucose metabolism during T2DM by using the natural dietary bioactive components. C3G promotes the phosphorylation of IRS-2 proteins by suppressing the expression of PTP1B, and then enhances the sensitivity of hepatocyte to insulin.

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