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20 resultsShowing papers similar to Impact of a real food matrix and in vitro digestion on properties and acute toxicity of polystyrene microparticles
ClearExploring the role of real food matrices on the behavior and toxicity of polystyrene nanoplastics during digestion simulation
Researchers investigated how polystyrene nanoplastics behave and affect cells when consumed alongside real food, using milk as the test matrix, during simulated digestion. They found that food proteins and digestive enzymes formed a coating around the nanoplastics that changed their aggregation behavior and reduced their toxicity compared to nanoplastics alone. The study suggests that the presence of food during digestion may significantly alter how nanoplastics interact with the body, an important factor often overlooked in toxicity studies.
The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics
Researchers studied how the human digestive process changes the physical and biological properties of polystyrene nanoplastics. They found that digestive fluids altered the surface characteristics of the particles, potentially affecting how they interact with gut cells. The study suggests that the form of nanoplastics that actually reaches our intestines may behave differently than the pristine particles typically used in lab studies.
Influence of the digestive process on intestinal toxicity of polystyrene microplastics as determined by in vitro Caco-2 models
Researchers studied how the human digestive process transforms polystyrene microplastics and affects their intestinal toxicity using in vitro Caco-2 cell models. The study found that digestion formed a corona on microplastic surfaces without altering their chemical composition, and that smaller particles (100 nm) showed higher toxicity than larger ones (5 micrometers) regardless of digestive treatment.
Small polystyrene microplastics interfere with the breakdown of milk proteins during static in vitro simulated human gastric digestion
Researchers found that small polystyrene microplastics interfere with the digestion of milk proteins in a simulated human stomach environment. The microplastics adsorbed the digestive enzyme pepsin onto their surface, reducing its activity and slowing the breakdown of proteins like casein and whey. The study suggests that microplastic contamination in food could impair normal digestive processes in the human gut.
Impact of food matrices on the characteristics and cellular toxicities of ingested nanoplastics in a simulated digestive tract
Researchers investigated how different food components affect the toxicity of polystyrene nanoplastics as they pass through a simulated human digestive system. They found that fat molecules helped stabilize and disperse the nanoplastics during digestion, increasing their uptake by intestinal cells and worsening cellular damage. The study suggests that the type of food consumed alongside nanoplastic-contaminated items could significantly influence how much harm the particles cause in the gut.
The in vitro gastrointestinal digestion-associated protein corona of polystyrene nano- and microplastics increases their uptake by human THP-1-derived macrophages
When polystyrene nano- and microplastics pass through simulated gastrointestinal digestion, they acquire a coating of gut proteins — a 'protein corona' — that dramatically increases their uptake by human immune cells (macrophages), boosting internalization of small neutral particles by up to six-fold compared to undigested plastic. The identity of the proteins driving this effect, including clotting factors and apolipoproteins, suggests that realistic dietary exposure conditions substantially change how microplastics interact with the body, and that lab tests using undigested plastics likely underestimate actual cellular uptake.
Interactions between polystyrene nanoplastics and bovine lactoferrin in simulated gastric fluids: Aggregation kinetics and impact on protein digestion
This study investigated how polystyrene nanoplastics with different surface charges interact with bovine lactoferrin in simulated gastric conditions, affecting both particle aggregation and protein digestion. The findings show that nanoplastic-protein interactions in the stomach could alter the digestibility of dietary proteins, with implications for nutritional and gut health.
Effects of weathering and simulated gastric fluid exposure on cellular responses to polystyrene particles
Researchers studied the effects of weathering and simulated gastric fluid exposure on cellular responses to polystyrene particles. The study suggests that environmental weathering can alter how micro- and nanoplastics interact with biological systems, with potential implications for understanding human health effects from ingested plastic particles.
Digestion of Polystyrene Nanoparticles in a Whey Protein Drink. a Simulated in Vitro Gastrointestinal Digestion Using a Batch Infogest Model Combined with Cell Absorption Experiments
This study tracked polystyrene nano- and microplastic particles through a simulated digestive process mixed with a whey protein drink, then tested whether the particles could be absorbed by human intestinal cells. The work contributes to understanding how dietary microplastics survive digestion and whether they can pass through the gut lining into the body.
Cellular interactions with polystyrene nanoplastics—The role of particle size and protein corona
Researchers investigated how polystyrene nanoplastics interact with mammalian cells, finding that particle size and the protein corona that forms around particles in biological fluids strongly influence cellular uptake and toxicity. Smaller nanoplastics penetrated cell membranes more readily and caused greater disruption, suggesting that the tiniest plastic particles may pose the greatest biological risk.
Fate, uptake and impact of fit-for-purpose nanoplastics on the digestive environment: an in vitro-in vivo continuum study
Researchers used fluorescently and gold-labeled polystyrene nanoplastics as models to study how these particles behave in the digestive environment and what effects they have on gut health. The study revealed that nanoplastics interact with the digestive system in ways that depend on particle labeling and surface properties.
Microplastics interactions and transformations during in vitro digestion with milk
This study simulated human digestion to see how microplastics change as they pass through the stomach and intestines, with and without milk. Microplastics digested with milk showed 15-25% more clumping due to milk proteins coating the plastic surfaces, and the digestive process caused chemicals to leach from the plastics. The findings suggest that microplastics in food may become more biologically active during digestion, potentially increasing their ability to interact with the body.
Unraveling the impact of polystyrene microplastics with varying particle sizes and concentrations on lipid in vitro digestion and ex vivo absorption
Researchers investigated how polystyrene microplastics of different sizes and concentrations affect fat digestion and absorption using laboratory and tissue-based models. They found that microplastics interfered with the digestive process by interacting with digestive enzymes and bile salts, and that smaller particles at higher concentrations had the greatest inhibitory effect on fat absorption. The findings suggest that microplastics consumed with food could alter how the body processes dietary fats.
The in vitro gastrointestinal digestion-associated protein corona of polystyrene nano- and microplastics increases their uptake by human THP-1-derived macrophages
When microplastics pass through the digestive system, stomach and intestinal proteins coat them in a layer called a "protein corona" that makes immune cells absorb the smallest particles up to six times more readily than undigested ones. This finding means that the body's own digestive process may actually increase how much microplastic gets taken up by immune cells, which is important for accurately assessing health risks from swallowed plastics.
Structure of soft and hard protein corona around polystyrene nanoplastics—Particle size and protein types
Researchers characterized the protein corona that forms around polystyrene nanoplastics of different sizes, finding that particle size influences which proteins bind and how tightly, with implications for nanoplastic toxicity and biological uptake.
Aggregation kinetics of polystyrene nanoplastics in gastric environments: Effects of plastic properties, solution conditions, and gastric constituents
Researchers studied how polystyrene nanoplastics clump together (aggregate) inside simulated human stomach fluid under conditions mimicking fasting and different feeding states. They found that smaller particles aggregate faster, lower stomach pH accelerates clumping, and stomach proteins coat the plastic particles and dramatically change how they behave — findings that matter for understanding how nanoplastics travel through the human digestive system after ingestion.
Microplastics in our diet: complementary in vitro gut and epithelium models to understand their fate in the human digestive tract.
Researchers used complementary in vitro gut models to study how microplastics behave during human digestion, finding that digestive conditions alter microplastic surface properties and their interactions with gut cells. The work advances understanding of how ingested microplastics may affect the human digestive system.
Unravelling protein corona formation on pristine and leached microplastics
Researchers found that when microplastics encounter proteins in biological fluids, they get coated in a "protein corona" that depends heavily on the plastic's chemical additives, surface area, and how much it has been weathered in the environment. This coating changes how microplastics behave in the body, meaning toxicity studies need to account for these real-world surface changes.
Elucidating the Size‐Dependency of In Vitro Digested Polystyrene Microplastics on Human Intestinal Cells Health and Function
Polystyrene microplastics of different sizes were subjected to simulated in vitro digestion and then applied to human intestinal cells, with smaller particles causing greater disruption to cell health and barrier function than larger ones. The results suggest that the smallest microplastics reaching the human gut pose the greatest risk to intestinal integrity.
Influence of artificial digestion on characteristics and intestinal cellular effects of micro-, submicro- and nanoplastics
Researchers simulated human digestion to study how micro-, submicro-, and nanoplastics change as they pass through the stomach and intestines. They found that the digestive process altered the surface properties and size distribution of the plastic particles, potentially affecting how they interact with intestinal cells. The study suggests that the body's digestive environment may transform plastic particles in ways that influence their biological impact.