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61,005 resultsShowing papers similar to The Essential Oil from Conyza bonariensis (L.) Cronquist (Asteraceae) Exerts an In Vitro Antimelanoma Effect by Inducing Apoptosis and Modulating the MAPKs, NF-κB, and PKB/AKT Signaling Pathways
ClearChemical Composition, In Vitro Antitumor Effect, and Toxicity in Zebrafish of the Essential Oil from Conyza bonariensis (L.) Cronquist (Asteraceae)
Researchers analyzed the essential oil from the plant Conyza bonariensis and found it showed selective activity against melanoma cells in laboratory tests. The study used zebrafish as a model to assess toxicity and identified the compound lachnophyllum ester as the major component of the oil.
Morroniside Protects Human Granulosa Cells against H2O2-Induced Oxidative Damage by Regulating the Nrf2 and MAPK Signaling Pathways
Researchers found that morroniside protects human ovarian granulosa cells from oxidative damage by activating the Nrf2 antioxidant pathway and reducing apoptosis through regulation of p38 and JNK signaling pathways.
Ursolic Acid Suppresses Proliferation and Elicits Apoptosis of Laryngeal Carcinoma Cell HEp-2 through Activation of ROS Synthesis and Inhibition of Multiple Signaling Pathways
Researchers investigated the anticancer effects of ursolic acid on laryngeal squamous cell carcinoma HEp-2 cells, finding that it suppressed proliferation and induced apoptosis by stimulating reactive oxygen species (ROS) synthesis. The ROS increase was linked to activation of MAPK, PI3K/Akt, NF-κB, and STAT3 signaling pathways, positioning ursolic acid as a potential phytochemical therapeutic candidate for laryngeal carcinoma.
Mechanism of P-Hydroxy Benzyl Alcohol Against Cerebral Ischemia Based on Metabonomics Analysis
Researchers investigated how p-hydroxybenzyl alcohol, an active compound from the traditional medicinal plant Gastrodia elata, protects against brain damage caused by reduced blood flow. Using metabolomics in cell and rat models, they identified that the compound works by improving mitochondrial function and reducing excessive autophagy through a specific signaling pathway. The study provides new molecular targets that could inform future treatments for cerebral ischemia.
Maltol has anti-cancer effects via modulating PD-L1 signaling pathway in B16F10 cells
Researchers found that maltol, a natural compound with antioxidant and anti-inflammatory properties, showed anti-melanoma activity by suppressing the PD-L1 immune checkpoint signaling pathway in mouse skin cancer cells. The compound enhanced the effectiveness of cisplatin chemotherapy and increased immune cell-mediated destruction of cancer cells. The study suggests that maltol may have potential as a complementary agent in melanoma immunotherapy approaches.
Uncovering the Anticancer Potential of Polydatin: A Mechanistic Insight
This review examines the anticancer mechanisms of polydatin, a natural stilbenoid compound, detailing its ability to inhibit tumor growth through antioxidant, anti-inflammatory, and apoptotic pathways across multiple cancer types.
Quercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells
Researchers found that quercetin, a natural plant compound, protected mouse ovaries from chemotherapy-induced damage by reducing harmful oxidative stress in mitochondria and suppressing a form of inflammatory cell death called pyroptosis, suggesting it could help preserve fertility in patients undergoing cancer treatment.
Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells
Researchers found that oridonin, a natural plant compound, can trigger two different types of cell death simultaneously in bone cancer cells. This dual mechanism makes it effective at suppressing tumor growth in osteosarcoma. The study suggests oridonin could be a promising therapeutic agent for treating this type of bone cancer.
The Potential Role and Effective Components of Sanyeqing as the Potential Therapeutic Candidates for IBD and CRC
This review examines the phytochemical constituents of Sanyeqing (a traditional medicinal plant) and their therapeutic potential for inflammatory bowel disease and colorectal cancer, identifying anti-inflammatory and anti-tumor mechanisms that could complement conventional treatments.
Methanol Extracts from Cirsium japonicum DC. var. australe Kitam. and Their Active Components Reduce Intracellular Oxidative Stress in Caenorhabditis elegans
Methanol extracts from different parts (flowers, leaves, stems, roots) of Cirsium japonicum var. australe were evaluated for antioxidant activity and their potential to reduce lipid accumulation, with the flower extracts showing the strongest bioactivity.
Sakuranetin: A multifaceted study from plant resistance to pharmacological activity
This review synthesized 15 years of research on sakuranetin, a plant flavonoid, covering its biosynthesis, role in plant stress resistance, and pharmacological activities including anti-inflammatory, antiviral, and anticancer properties.
Transcriptomic Analysis Reveals the Flavonoid Biosynthesis Pathway Involved in Rhizome Development in Polygonatum cyrtonema Hua
Researchers used transcriptomic analysis to map the flavonoid biosynthesis pathways in the rhizomes of Polygonatum cyrtonema, a traditional medicinal plant. The study identified key genes and transcription factors involved in flavonoid accumulation, providing a molecular foundation for understanding how this plant produces compounds with antioxidant and other bioactive properties.
Tanshinone IIA May Inhibit Gastric Cancer via Affecting the Intestinal Microbiome
Researchers investigated whether tanshinone IIA, a compound derived from Salvia miltiorrhiza, inhibits gastric cancer tumor growth through modulation of the intestinal microbiome and regulation of NF-kB signaling. The study found that tanshinone IIA altered the gut microbial composition and suppressed NF-kB pathway activity, suggesting a microbiome-mediated mechanism underlying its anti-tumor effects.
Ethanol Extract of Rosa rugosa Ameliorates Acetaminophen-Induced Liver Injury via Upregulating Sirt1 and Subsequent Potentiation of LKB1/AMPK/Nrf2 Cascade in Hepatocytes
Researchers prepared an ethanol extract from Rosa rugosa flower buds and found it significantly reduced liver damage caused by acetaminophen overdose in both cell and mouse models. The extract worked by activating the Sirt1 protein and boosting a protective signaling pathway that counters oxidative stress in liver cells. The study suggests Rosa rugosa extract may have potential as a natural intervention for drug-induced liver injury.
Marine Natural Products: A Source of Novel Anticancer Drugs
This review explores marine natural products as potential sources for new anticancer drugs, highlighting compounds derived from marine plants, algae, bacteria, fungi, and invertebrates. Researchers found that marine organisms produce diverse bioactive metabolites with unique chemical structures that show promise against cancer cells. The study underscores the ocean as a largely untapped reservoir of compounds that could lead to novel therapeutic approaches.
Chemical Profiling and Biological Activity of Psydrax dicoccos Gaertn
This study profiled the chemical composition and biological activity of Psydrax dicoccos leaf and bark extracts, testing their potential against breast cancer cells as a safer natural alternative to synthetic chemotherapy drugs.
Morroniside protect human granulosa cells against H2O2-induced oxidative damage via regulating Nrf2 and MAPK signaling pathway
This study investigated whether morroniside, a compound from the Cornus plant, can protect ovarian cells from oxidative stress-induced damage. The research found protective effects in lab experiments, relevant to understanding how environmental oxidative stressors—including pollutants like microplastics—may affect female reproductive cells.
Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease
Researchers reviewed natural bioactive compounds from plant sources for their potential neuroprotective effects related to Alzheimer's disease. The study highlights how these compounds may modulate molecular mechanisms involved in disease development, while noting challenges such as limited bioavailability and blood-brain barrier permeability.
Gastroprotective Effects of Periplaneta americana L. Extract Against Ethanol-Induced Gastric Ulcer in Mice by Suppressing Apoptosis-Related Pathways
Researchers examined the gastroprotective effects of Periplaneta americana extract against ethanol-induced gastric ulcers in mice, finding that the extract suppressed apoptosis-related pathways and protected gastric tissue from programmed cell death.
Trends, key contributors, and emerging issues in honey and breast cancer: A bibliometric analysis from 2014 to 2024
A bibliometric analysis of 2014–2024 literature on honey and breast cancer identified nine research clusters covering bioactive compounds, anticancer mechanisms, and combination therapies, revealing growing interest in honey's polyphenol content as a complementary approach to breast cancer prevention and treatment.
Oxidative Stress and AKT-Associated Angiogenesis in a Zebrafish Model and Its Potential Application for Withanolides
Oxidative stress and AKT signaling pathway interactions were examined in a zebrafish model to evaluate the potential of withanolides, a class of plant compounds from the Solanaceae family, as modulators of angiogenesis. The study identifies several withanolides as candidates for anti-angiogenic applications based on their ability to suppress oxidative stress and AKT-associated vascular signaling.
Integration of transcriptomics and metabolomics reveals the mechanism of Lycium barbarum polysaccharides inhibited MCF-7 cell proliferation
Researchers used transcriptomics and metabolomics to investigate how Lycium barbarum polysaccharides inhibit MCF-7 breast cancer cell proliferation, identifying the molecular mechanisms and signaling pathways responsible for the compound's anticancer activity at an optimal dose of 8 mg/mL.
Honokiol Microemulsion Causes Stage-Dependent Toxicity Via Dual Roles in Oxidation-Reduction and Apoptosis through FoxO Signaling Pathway
Honokiol microemulsion caused stage-dependent developmental toxicity in zebrafish and rats, with early exposure triggering oxidative stress and later exposure activating apoptosis through the FoxO signaling pathway. These findings establish critical time windows for honokiol toxicity, important safety data as this compound advances through lung cancer clinical trials.
The potential mechanism of huazhuojiedu decoction in the treatment of ulcerative colitis based on network pharmacology and experimental validation
Researchers used network pharmacology to identify 119 active components and 146 potential targets of the traditional Chinese medicine formula Huazhuojiedu decoction relevant to ulcerative colitis, then validated key predicted mechanisms in dextran sulfate sodium-induced rat colitis models, elucidating multi-target pathways underlying the formula's clinically observed therapeutic effects.