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Marine Natural Products: A Source of Novel Anticancer Drugs

Marine Drugs 2019 542 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 60 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Shaden A. M. Khalifa, Hesham R. El‐Seedi Shaden A. M. Khalifa, Aida A. Abd El‐Wahed, Nizar Elias, Aida A. Abd El‐Wahed, Mohamed A. Farag, Hesham R. El‐Seedi Mohamed A. Farag, Aamer Saeed, Hesham R. El‐Seedi Shaden A. M. Khalifa, Lei Chen, Shaden A. M. Khalifa, Hesham R. El‐Seedi Fang‐Rong Chang, Aamer Saeed, Hesham R. El‐Seedi Mohamed‐Elamir F. Hegazy, Hesham R. El‐Seedi Hesham R. El‐Seedi Syed Ghulam Musharraf, Moustafa S. Moustafa, Moustafa S. Moustafa, Aida A. Abd El‐Wahed, Saleh Mohammed Al‐Mousawi, Syed Ghulam Musharraf, Fang‐Rong Chang, Arihiro Iwasaki, Kiyotake Suenaga, Shaden A. M. Khalifa, Muaaz Alajlani, Shaden A. M. Khalifa, Ulf Göransson, Hesham R. El‐Seedi

Summary

This review explores marine natural products as potential sources for new anticancer drugs, highlighting compounds derived from marine plants, algae, bacteria, fungi, and invertebrates. Researchers found that marine organisms produce diverse bioactive metabolites with unique chemical structures that show promise against cancer cells. The study underscores the ocean as a largely untapped reservoir of compounds that could lead to novel therapeutic approaches.

Study Type In vivo

Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.

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