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61,005 resultsShowing papers similar to RETRACTED ARTICLE: Sciadopitysin mitigates spermatological and testicular damage instigated by paraquat administration in male albino rats
ClearSciadopitysin attenuates paraquat induced renal toxicity by modulating Nrf2/Keap-1 pathway in male albino rats
Researchers investigated whether the plant compound sciadopitysin could protect against kidney damage caused by the herbicide paraquat in rats. They found that sciadopitysin significantly reduced oxidative stress and inflammation in the kidneys by activating the Nrf2/Keap-1 protective pathway. The study suggests that natural biflavonoid compounds may help mitigate organ damage from toxic environmental chemical exposures.
Apigetrin ameliorates doxorubicin prompted testicular damage: biochemical, spermatological and histological based study
Researchers tested whether the flavonoid apigetrin could protect rat testicular tissue from damage caused by the chemotherapy drug doxorubicin. They found that doxorubicin caused significant oxidative stress, inflammation, hormone imbalance, and tissue damage in the testes, but co-administration of apigetrin substantially reduced these harmful effects. The study suggests that natural plant compounds may help protect reproductive health during cancer treatment.
The Possible Protective Effect of Luteolin in a Thioacetamide Rat Model of Testicular Toxicity
This animal study tested whether luteolin, a natural plant compound with antioxidant properties, could protect against testicular toxicity caused by thioacetamide. The study establishes an animal model for studying reproductive toxicity and evaluates whether natural antioxidants can mitigate oxidative damage to sperm-producing tissues.
Rhamnetin alleviates polystyrene microplastics-induced testicular damage by restoring biochemical, steroidogenic, hormonal, apoptotic, inflammatory, spermatogenic and histological profile in male albino rats
Researchers studied whether the plant compound rhamnetin could protect against testicular damage caused by polystyrene microplastics in rats. Microplastic exposure caused significant harm to sperm quality, hormone levels, and testicular tissue through oxidative stress and inflammation. Co-treatment with rhamnetin restored many of these markers, suggesting it may help counteract some of the reproductive harm associated with microplastic exposure.
Evaluation of possible attenuative role of chrysoeriol against polyethylene microplastics instigated testicular damage: A biochemical, spermatogenic and histological study
Researchers investigated whether the plant compound chrysoeriol could protect against testicular damage caused by polyethylene microplastics in a rat model. The study found that microplastic exposure reduced antioxidant enzyme activity and increased inflammation markers, while co-administration of chrysoeriol showed a protective effect by mitigating oxidative stress and preserving sperm quality.
Correction by "Quertin" of the oxidative-antioxidant system of rats at xenobiotics exposure
This study tested whether the antioxidant flavonoid quercetin could protect rats from oxidative damage caused by xenobiotic (foreign chemical) exposure, finding that quercetin administration reduced biomarkers of oxidative stress and liver damage. The results suggest that natural antioxidants may help counteract some biochemical effects of environmental chemical exposures.
Juglanin cures polyethylene microplastics-induced testicular damage in rats
Researchers administered juglanin to rats exposed to polyethylene microplastics and found that the natural flavonoid compound protected against microplastic-induced testicular damage by reducing oxidative stress and inflammation.
Mechanistic insight into the protective effects of fisetin against arsenic-induced reproductive toxicity in male rats
Researchers showed that arsenic — a heavy metal contaminant found alongside plastic pollution in many environments — severely damages sperm quality and hormone levels in male rats, and that the plant compound fisetin significantly reversed this damage. The results suggest fisetin may help protect male reproductive health from toxic environmental exposures.
Pharmacotherapeutic potential of ginkgetin against polystyrene microplastics–instigated testicular toxicity in rats: A biochemical, spermatological, and histopathological assessment
In a rat study, polystyrene microplastics caused significant damage to the testes, including reduced sperm quality, oxidative stress, and tissue inflammation, but the natural plant compound ginkgetin was able to partially reverse this damage. Ginkgetin worked by boosting antioxidant defenses and reducing the inflammatory response triggered by the microplastics. This suggests that natural antioxidant compounds might help protect male reproductive health from the harmful effects of microplastic exposure.
Pinostrobin alleviates testicular and spermatological damage induced by polystyrene microplastics in adult albino rats
Researchers found that pinostrobin, a natural flavonoid, alleviated testicular damage and sperm abnormalities induced by polystyrene microplastics in rats, suggesting it may be a potential therapeutic candidate for microplastic-related reproductive toxicity.
Metabolic–endocrine remodelling of the testis under polystyrene nanoplastic exposure: Intervention by organ-specific phytocomplexes of Nelumbo nucifera
Researchers found that polystyrene nanoplastics impair testosterone production and sperm quality in male rats by inducing testicular oxidative stress and disrupting cholesterol and energy metabolism, and showed that extracts from lotus plant organs — especially the rhizome — significantly protected testicular function through antioxidant and anti-inflammatory mechanisms.
Protective effect of Moringa oleifera leaf ethanolic extract against uranyl acetate-induced testicular dysfunction in rats
Researchers found that Moringa oleifera leaf extract protected rats from testicular damage caused by uranyl acetate, a toxic uranium compound, by boosting antioxidant defenses and reducing oxidative stress. While focused on uranium toxicity, the protective mechanisms studied are relevant to microplastics research because microplastics also cause testicular damage through oxidative stress in animal studies. Natural antioxidants like those in Moringa may help protect reproductive health from environmental pollutants.
Toxic effect of polyethylene microplastic on testicles and ameliorative effect of luteolin in adult rats: Environmental challenge
Researchers found that polyethylene microplastics caused significant testicular toxicity in adult rats including reduced sperm quality and testosterone levels, while luteolin treatment ameliorated these effects through its antioxidant and anti-inflammatory properties.
Attenuative effect of astilbin on polystyrene microplastics induced testicular damage: Biochemical, spermatological and histopathological-based evidences
Researchers found that astilbin, a natural plant compound, significantly reduced testicular damage caused by polystyrene microplastic exposure in rats. The microplastics disrupted hormone levels, sperm quality, and testicular tissue structure, but astilbin treatment counteracted these effects by boosting antioxidant defenses and reducing inflammation. The study suggests that natural antioxidant compounds may offer protective benefits against the reproductive harm associated with microplastic exposure.
Fucoidan from Cladosiphon okamuranus enhances antioxidant activity and prevents reproductive dysfunction in polystyrene microplastic-induced male rats
Researchers tested whether fucoidan, a compound extracted from brown seaweed, could protect against reproductive damage caused by polystyrene microplastic exposure in male rats. They found that fucoidan treatment enhanced antioxidant enzyme activity, reduced inflammation markers, and preserved testicular tissue structure and testosterone levels. The study suggests that fucoidan may help counteract microplastic-induced oxidative stress in reproductive tissues.
The effect of luteolin on spermatological parameters, apoptosis, oxidative stress rate in freezing rabbit semen
Researchers examined the effect of the flavonoid luteolin at four concentrations (25, 50, 100, and 200 µM) on semen quality, oxidative stress, apoptosis, acrosomal integrity, mitochondrial membrane potential, and dead sperm ratio in frozen-thawed New Zealand rabbit semen. Results showed no statistically significant differences between any luteolin dose and the control group across the assessed spermatological parameters.
Ameliorative Effects of Rhamnetin against Polystyrene Microplastics-Induced Nephrotoxicity in Rats
Researchers investigated whether the flavonoid rhamnetin could protect against kidney damage caused by polystyrene microplastics in rats. The study found that microplastic exposure significantly increased oxidative stress and inflammatory markers while reducing antioxidant enzyme activity, but co-treatment with rhamnetin restored kidney parameters and mitigated the damage.
Lutein Can Alleviate Oxidative Stress, Inflammation, and Apoptosis Induced by Excessive Alcohol to Ameliorate Reproductive Damage in Male Rats
Researchers found that high-dose lutein supplementation alleviated alcohol-induced male reproductive damage in rats by reducing oxidative stress, inflammation, and apoptosis in testicular tissue, restoring sperm quality and sex hormone levels.
Mitigative potential of kaempferide against polyethylene microplastics induced testicular damage by activating Nrf-2/Keap-1 pathway
Researchers tested whether kaempferide, a natural plant compound with antioxidant properties, could protect against testicular damage caused by polyethylene microplastics in rats. They found that the microplastics triggered significant oxidative stress and tissue damage in the testes, but kaempferide treatment substantially reduced these harmful effects by activating a key protective cellular pathway. The study suggests that natural antioxidant compounds may help counteract some of the reproductive harm associated with microplastic exposure.
Ameliorating potential of Cassia absus seed-powder against cadmium-induced alterations in Zebrafish and identification of flavonoids in different extracts of seed
Researchers investigated the protective effects of Cassia absus seed powder against cadmium-induced toxicity in zebrafish, finding it reduced oxidative stress and histological damage, while identifying flavonoid compounds in the seed extracts as likely active components.
Potential of Macang (Mangifera foetida) Bark Extract on Antioxidant Levels and Pro-Apoptotic Proteins in Rats (Rattus norvegicus) Exposed to Polystyrene Nanoplastics
Researchers assessed whether Mangifera foetida (macang) bark extract could protect male rats against reproductive and immune damage caused by polystyrene nanoplastic exposure, finding that the extract's antioxidant compounds partially restored superoxide dismutase activity and reduced apoptosis markers at 500 mg/kg doses.
Astragalus Polysaccharides Ameliorate the Toxic Effects of Polystyrene Nanoplastics on Boar Sperm
Scientists found that tiny plastic particles called nanoplastics can damage sperm cells by causing harmful chemical reactions, but a natural compound from the Astragalus plant can help protect against this damage. This study used pig sperm in lab dishes, so we don't know yet if the same protection would work in humans. The findings matter because microplastics are everywhere in our environment and food, and this research suggests natural antioxidants might help reduce their potential harm to reproductive health.
Potential of Cinnamomum burmanni Leaf Extract as an Exogenous Antioxidant and Spermatoprotective for Rattus norvegicus L. Exposed to Polystyrene Nanoplastics
Researchers tested whether Cinnamomum burmanni leaf extract could protect male rat reproductive function against polystyrene nanoplastic (NP) toxicity by acting as an exogenous antioxidant. NPs increased oxidative stress and impaired sperm quality and spermatogenic cell counts, while C. burmanni extract at 200–400 mg/kg restored SOD and CAT activity, improved sperm parameters, and protected testicular morphology.
Lycopene supplementation: effects on oxidative stress, sex hormones, gonads and thyroid tissue in tilapia Oreochromis niloticus during Harness® exposure
Researchers investigated whether lycopene supplementation could protect tilapia fish from the toxic effects of the herbicide Harness on oxidative stress, reproductive hormones, and thyroid function. The study found that Harness exposure disrupted antioxidant enzyme activity, altered sex hormone levels, and damaged gonadal and thyroid tissue, while lycopene supplementation helped mitigate some of these adverse effects.