Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Environmental Sources Human Health Effects Marine & Wildlife Reproductive & Development Sign in to save

Lycopene supplementation: effects on oxidative stress, sex hormones, gonads and thyroid tissue in tilapia Oreochromis niloticus during Harness® exposure

Frontiers in Physiology 2023 8 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 50 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Mohamed Hamed, Mohamed Hamed, Mohamed Hamed, Mohamed Hamed, Mohamed Hamed, Mohamed Hamed, Alaa El‐Din H. Sayed Mohamed Hamed, Mohamed Hamed, Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Mohamed Hamed, Mohamed Hamed, Mohamed Hamed, Mohamed Hamed, Rania F. Ismail, Rania F. Ismail, Rania F. Ismail, Mohamed Hamed, Mohamed Hamed, Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Mohamed Hamed, Mohamed Hamed, Mohamed Hamed, Mohamed Hamed, Mohamed Hamed, Mohamed Hamed, Mohamed Hamed, Alaa El‐Din H. Sayed Mohamed Hamed, Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Mohamed Hamed, Rania F. Ismail, Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Rania F. Ismail, Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Mohamed Hamed, Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed Alaa El‐Din H. Sayed

Summary

Researchers investigated whether lycopene supplementation could protect tilapia fish from the toxic effects of the herbicide Harness on oxidative stress, reproductive hormones, and thyroid function. The study found that Harness exposure disrupted antioxidant enzyme activity, altered sex hormone levels, and damaged gonadal and thyroid tissue, while lycopene supplementation helped mitigate some of these adverse effects.

Body Systems

Endocrine Reproductive

Models

Fish other

Harness® is a commercial herbicide that contains acetochlor at a concentration of 84% as an active ingredient. Ubiquitous, persistent, and substantial uses of Harness® in agricultural processes have resulted in the pollution of nearby water sources, posing a threat to various aquatic biotas, including fish. The effects of Harness® toxicity on fish health are little known. So, this study aimed to describe the impact of herbicide Harness® on the oxidative stress and reproductive and thyroid performance of male and female tilapia (Oreochromis niloticus) and also investigate the prospective role of the natural antioxidant lycopene supplementation in dismissing the adverse properties of Harness®. Antioxidant enzyme (catalase, superoxide dismutase, and total antioxidant capacity) and hormone measurements (T, E2, T3, and T4) were carried out, and gonadal and thyroid follicle histological sections were examined as a method to investigate the effects of Harness® toxicity on fish. Male and female tilapia were exposed to 10 μmol/L and 100 μmol/L of Harness® and treated with 10 mg lycopene/kg for 15 days of exposure. Our results demonstrated that the antioxidant enzyme activity was altered by Harness exposure and serum T for both males and females dropped; also, female E2 levels decreased, but male E2 increased. Exposure to higher dose of Harness® induced elevation in both T3 and T4 levels, although the low exposure dose stimulated T4 levels. Harness® exposure prompted histological variations and degenerative changes in testicular, ovarian, and thyroid follicle tissues. Lycopene supplement administration diminished oxidative stress induced by Harness®, alleviating its endocrine disparaging effects by neutralizing T3, T4, T, and E2 and ameliorating the histological structure of gonadal and thyroid tissues. In conclusion, lycopene supplementation was preformed to normalize the alterations and oxidative damage caused by Harness® in Nile tilapia, suggesting that lycopene-supplemented diet functioned as potent antioxidants and had the ability to alleviate oxidative stress and thyroid and reproductive toxicity caused by herbicide Harness®. Moreover, it is crucial to take appropriate care when consuming herbicides to defend the aquatic environment.

Read via DOI Download PDF

Share this paper

Post Share Share Pin Email