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61,005 resultsShowing papers similar to Santacruzamate A Alleviates Pain and Pain-Related Adverse Emotions through the Inhibition of Microglial Activation in the Anterior Cingulate Cortex
ClearEpigallocatechin-3-gallate ameliorates polystyrene microplastics-induced anxiety-like behavior in mice by modulating gut microbe homeostasis
A mouse study found that exposure to polystyrene microplastics caused anxiety-like behavior by disrupting gut bacteria and triggering brain inflammation. A green tea compound called EGCG (epigallocatechin-3-gallate) reversed these effects by restoring healthy gut microbe balance and reducing inflammation in the brain. This suggests the gut-brain connection plays a key role in how microplastics affect mental health, and that certain dietary compounds might offer protection.
Cyanidin-3- O-glucoside alleviates trimethyltin chloride-induced neurodegeneration by maintaining glutamate homeostasis through modulation of the gut microbiota
Researchers found that cyanidin-3-O-glucoside, a common dietary anthocyanin found in berries and other foods, helped protect against chemically induced neurodegeneration in mice by restoring glutamate balance in the brain. The study suggests that this protective effect is mediated through modulation of gut microbiota, highlighting a potential gut-brain connection in neuroprotection.
Neuroprotective compounds from marine invertebrates
Researchers reviewed biologically active compounds found in marine invertebrates like sponges, sea cucumbers, and coral, many of which show potential for treating neuroinflammatory diseases such as Alzheimer's and Parkinson's by targeting key proteins involved in brain inflammation and cell death. While promising, the review notes that challenges around sustainable sourcing and the need for more clinical trials remain significant hurdles before these marine compounds reach patients.
Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo
Researchers isolated a compound called petrosamine from a Brazilian marine sponge and tested its ability to protect against neurotoxicity in both human neuroblastoma cells and zebrafish embryos, finding it showed promise against hallmarks of Alzheimer's disease. The results suggest that ocean-derived compounds may offer new avenues for developing treatments for neurodegenerative diseases.
Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease
Researchers reviewed natural bioactive compounds from plant sources for their potential neuroprotective effects related to Alzheimer's disease. The study highlights how these compounds may modulate molecular mechanisms involved in disease development, while noting challenges such as limited bioavailability and blood-brain barrier permeability.
A review on health benefits of marine based neutraceuticals on pancreatic cancer
This review examined health benefits of marine-based nutraceuticals for pancreatic cancer prevention and treatment, finding that bioactive compounds from marine organisms show anti-inflammatory, antioxidant, and antitumor properties with potential to complement therapies for this highly treatment-resistant malignancy.
Marine Natural Products: A Source of Novel Anticancer Drugs
This review explores marine natural products as potential sources for new anticancer drugs, highlighting compounds derived from marine plants, algae, bacteria, fungi, and invertebrates. Researchers found that marine organisms produce diverse bioactive metabolites with unique chemical structures that show promise against cancer cells. The study underscores the ocean as a largely untapped reservoir of compounds that could lead to novel therapeutic approaches.
Beneficial effect of Xuebijing against Pseudomonas aeruginosa infection in Caenorhabditis elegans
Researchers found that the traditional Chinese medicine formulation Xuebijing protected Caenorhabditis elegans against Pseudomonas aeruginosa infection by enhancing immune pathways and reducing bacterial colonization, providing mechanistic insight into its clinical use for treating sepsis.
Compounds of Marine Origin with Possible Applications as Healing Agents
This paper is not relevant to microplastics research; it reviews bioactive compounds from marine organisms and their potential applications in wound healing and cosmetic formulations, with no focus on plastic contamination.
The Impact of Microalgae and Their Bioactive Compounds on Liver Well-being in Rats Subjected to Synthetic Phenolic Antioxidants
This review examines how microalgae and their bioactive compounds — including polysaccharides, pigments, and polyphenols — protect liver health in animal models, summarizing evidence for anti-inflammatory and antioxidant mechanisms. The authors note that algal-derived compounds show hepatoprotective effects in rodent studies, though human clinical evidence remains limited.
Rosmarinic acid alleviates intestinal inflammatory damage and inhibits endoplasmic reticulum stress and smooth muscle contraction abnormalities in intestinal tissues by regulating gut microbiota
This study found that rosmarinic acid, a natural plant compound, protected mice from intestinal inflammation by restoring healthy gut bacteria and reducing cell stress and damage. While not directly about microplastics, the research is relevant because microplastics are known to cause similar gut inflammation and disrupt the gut microbiome. Understanding how natural compounds can repair gut damage may help develop strategies to counteract the harmful effects of microplastic exposure on digestive health.
From Ocean to Medicine: Harnessing Seaweed’s Potential for Drug Development
This review explores how compounds derived from seaweed show promise for drug development, with properties including antioxidant, anti-inflammatory, and anticancer activity. While not directly about microplastics, marine-derived bioactive compounds could be relevant to addressing the inflammation and oxidative stress that microplastic exposure is known to cause in the body.
Revealing the underlying mechanisms of nanoplastics induces neuroinflammation: From transcriptomic analysis to in vivo and in vitro validation
This study investigated how nanoplastics cause brain inflammation in mice. Researchers found that polystyrene nanoplastics accumulated in the brain, triggered anxiety-like behavior and cognitive problems, and activated inflammatory pathways involving NF-kappaB signaling. The evidence indicates that nanoplastics can cross into the brain and activate immune cells there, pointing to specific molecular mechanisms that may underlie the neurological effects of plastic particle exposure.
Targeting NF-κB Signaling: Selected Small Molecules Downregulate Pro-Inflammatory Cytokines in Both Food Allergen and LPS-Induced Inflammation
This study found that two natural food compounds, vanillyl alcohol and lauric acid, can reduce inflammation by blocking the NF-kB pathway, a key driver of chronic inflammatory diseases. While not directly about microplastics, the NF-kB pathway is one of the main ways that microplastic exposure triggers inflammation in the body. These findings suggest that certain dietary compounds could help mitigate the inflammatory effects of environmental pollutants like microplastics.
Assessment of the protective and ameliorative impact of quercetin nanoparticles against neuronal damage induced in the hippocampus by acrolein
Researchers found that quercetin nanoparticles — tiny particles of a natural antioxidant found in plants — protected brain cells in the hippocampus from damage caused by acrolein, a toxic compound linked to Alzheimer's disease, suggesting nanoparticle delivery of quercetin as a potential therapeutic strategy.
Quercetin intervention mitigates small intestinal damage and immunologic derangement induced by polystyrene nanoplastics: Insights from multi-omics analysis in mice
Researchers found that quercetin, a natural compound found in fruits and vegetables, protected mice from gut damage and immune system disruption caused by polystyrene nanoplastics. The nanoplastics damaged the small intestine and disrupted immune balance, but quercetin reversed much of this harm by restoring healthy gut bacteria and gene activity. This suggests that dietary compounds like quercetin might help counteract some negative health effects of nanoplastic exposure.
Resveratrol alleviates oxidative stress, inflammatory cytokine expression and apoptosis induced by nanoplastics in the hemocytes of abalone (Haliotis discus hannai)
Researchers exposed abalone immune cells (hemocytes) to nanoplastics and found that the natural compound resveratrol — found in grapes and red wine — significantly reduced the resulting oxidative stress, inflammation, and cell death. Resveratrol worked by activating protective antioxidant and anti-inflammatory signaling pathways, suggesting it may help marine organisms defend against the cellular damage caused by nanoplastic exposure.
Polystyrene nanoplastics exposure trigger cognitive impairment mitigated by luteolin modulated glucose-6-phosphate dehydrogenase/glutathione-dependent pathway
Polystyrene nanoplastics caused cognitive impairment and brain damage in mice by disrupting a key antioxidant pathway, but the natural plant compound luteolin (found in celery, peppers, and other foods) significantly reduced this damage. Luteolin protected brain cells by boosting a specific enzyme that maintains the cell's antioxidant defenses against nanoplastic-induced stress. This study suggests that certain dietary compounds might help protect the brain from the harmful effects of nanoplastic exposure.
Insights into the Neuroprotective Potential of Epicatechin: Effects against Aβ-Induced Toxicity in Caenorhabditis elegans
This study found that epicatechin, a natural compound found in foods like cocoa and green tea, reduced the signs of Alzheimer's disease in a worm model by lowering harmful protein buildup and oxidative stress. While not about microplastics, the research is relevant because microplastic exposure has been shown to increase oxidative stress and inflammation in the brain. Natural antioxidants like epicatechin could potentially help counteract some of the neurological damage associated with environmental pollutant exposure.
Metabolite itaconate in host immunoregulation and defense
Researchers reviewed how itaconate — a small molecule produced naturally by immune cells during infection — acts as a master regulator of inflammation and oxidative stress in macrophages (the body's frontline immune defenders). Understanding itaconate's pathways may open new treatment strategies for inflammatory diseases and cancer.
Glyceroglycolipids in marine algae: A review of their pharmacological activity
This review examines the pharmacological activities of glyceroglycolipids from marine algae, highlighting their anti-inflammatory, antioxidant, antiviral, and antitumor properties and their potential applications in medicine and cosmetics.
Polystyrene microplastics induce anxiety via HRAS derived PERK-NF-κB pathway
Researchers found that polystyrene microplastics accumulated in the brains of mice and caused anxiety-like behavior by activating inflammation in brain immune cells (microglia) through a specific molecular pathway involving the HRAS protein. This study identifies a concrete biological mechanism for how microplastics in the brain could contribute to anxiety and other neurological symptoms.
Micro-algal astaxanthin ameliorates polystyrene microplastics-triggered necroptosis and inflammation by mediating mitochondrial Ca2+ homeostasis in carp’s head kidney lymphocytes (Cyprinus carpio L.)
Researchers investigated whether astaxanthin, a natural pigment from microalgae, could protect carp immune cells from damage caused by polystyrene microplastics. They found that astaxanthin reduced inflammation and cell death triggered by microplastics by helping maintain calcium balance within the cells' mitochondria. The study suggests that natural antioxidant compounds may help mitigate some of the harmful immune effects of microplastic exposure in fish.
Huperzine A ameliorates neurological deficits after spontaneous subarachnoid hemorrhage through endothelial cell pyroptosis inhibition
Researchers investigated how the compound Huperzine A affects brain damage following spontaneous subarachnoid hemorrhage in rats. They found that the treatment reduced blood-brain barrier damage and brain swelling by blocking a type of inflammatory cell death in blood vessel cells. The study suggests that Huperzine A may offer protective benefits for brain health after hemorrhagic stroke through its anti-inflammatory and antioxidant properties.