We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Cyanidin-3- O-glucoside alleviates trimethyltin chloride-induced neurodegeneration by maintaining glutamate homeostasis through modulation of the gut microbiota
Summary
Researchers found that cyanidin-3-O-glucoside, a common dietary anthocyanin found in berries and other foods, helped protect against chemically induced neurodegeneration in mice by restoring glutamate balance in the brain. The study suggests that this protective effect is mediated through modulation of gut microbiota, highlighting a potential gut-brain connection in neuroprotection.
Trimethyltin chloride (TMT) is a potent neurotoxin to cause neurodegeneration, especially in hippocampus. This study aimed to identify dietary components that can effectively attenuate TMT-induced neurodegeneration in humans. The predominant anthocyanin in human diets, cyanidin-3-O-glucoside (C3G, 5 or 50 mg/kg), was given to mice for 16 days, and TMT (2.7 mg/kg) was injected intraperitoneally once on the eighth day. C3G (50 mg/kg) significantly alleviated TMT-induced seizures and subsequent cognitive impairment by ameliorating hippocampal neurodegeneration and synaptic dysfunction. Furthermore, C3G treatment restored glutamate homeostasis in brain and reversed glutamine synthetase (GS) inhibition in reactive astrogliosis and neuroinflammation, which are critical for C3G’s neuroprotective effects. Notably, C3G decreased the lipopolysaccharide, tumor necrosis factor-α, interleukin-6, and interleukin-1β levels in the mice, which potentially by modulating the relative abundance of Atopobiaceae and Lachnospiraceae in the gut. C3G may be a promising and practical dietary component for reducing TMT-induced neurodegeneration.
Sign in to start a discussion.
More Papers Like This
Food-derived cyanidin-3-O-glucoside reverses microplastic toxicity via promoting discharge and modulating the gut microbiota in mice
Researchers found that cyanidin-3-O-glucoside (C3G), a naturally occurring anthocyanin compound found in many fruits and vegetables, helped reduce the harmful effects of polystyrene microplastics in mice. C3G supplementation promoted the excretion of microplastics, reduced tissue accumulation, and alleviated oxidative stress and inflammation caused by the particles. The study also showed that C3G helped restore healthy gut microbiota that had been disrupted by microplastic exposure.
Characterizing the Gut Microbial Metabolic Profile of Mice with the Administration of Berry-Derived Cyanidin-3-Glucoside
This paper is not about microplastics — it characterizes how the berry-derived compound cyanidin-3-glucoside alters gut microbiome composition and metabolic profiles in mice.
Modulation of Gut Microbial Metabolism by Cyanidin-3-O-Glucoside in Mitigating Polystyrene-Induced Colonic Inflammation: Insights from 16S rRNA Sequencing and Metabolomics
A natural plant compound called cyanidin-3-O-glucoside (C3G), found in red bayberry and other berries, reduced colon inflammation caused by polystyrene microplastic exposure in mice. C3G worked by reshaping the gut bacteria community and restoring healthy levels of anti-inflammatory signaling molecules. This suggests that certain dietary antioxidants may help protect the gut from damage caused by microplastic exposure.
Anthocyanins as protectors of gut microbiota: mitigating the adverse effects of microplastic-induced disruption
This review examines how anthocyanins, bioactive compounds found in berries and other pigmented plants, may protect gut microbiota from disruption caused by microplastic exposure. Researchers synthesized evidence suggesting that anthocyanins counteract microplastic-induced oxidative stress and inflammation in the gut. The findings indicate that dietary anthocyanins could serve as a protective factor against the adverse effects of microplastics on digestive health.
Canidin-3-glucoside prevents nano-plastics induced toxicity via activating autophagy and promoting discharge
Researchers showed that cyanidin-3-glucoside (C3G), a natural anthocyanin, reduced polystyrene nanoplastic toxicity in Caco-2 cells and C. elegans by activating autophagy and promoting cellular discharge of internalized particles, suggesting a dietary protective mechanism.