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Papers
61,005 resultsShowing papers similar to Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic Imaging
ClearResilient anatomy and local microplasticity of naïve and stress hematopoiesis
Researchers developed imaging approaches to visualize the spatial organization of normal and stress-induced blood cell production in bone marrow, revealing the resilient anatomy and local microplasticity — structural adaptability at small scales — that allows hematopoiesis to maintain output under physiological stress.
Discovery and analysis of microplastics in human bone marrow
For the first time, researchers detected microplastics in human bone marrow, finding plastic particles in all 16 samples tested. The most common types were polyethylene and polystyrene, with about 90% of particles smaller than 100 micrometers. This discovery shows that microplastics can penetrate deep into the body and reach the tissue where blood cells are made, raising questions about potential effects on blood cell production and immune function.
Strategies of neutrophil diversification
Researchers reviewed the expanding functional repertoire of neutrophils — the most abundant white blood cells — arguing that beyond infection defense, they participate in tissue homeostasis and chronic disease through transcriptional diversification strategies that allow functional specialization across different tissue environments.
Identification of functional immune and neuronal tumour cells in glioma
Researchers developed the Single Cell Rule Association Mining (SCRAM) computational tool to integrate RNA-inferred genomic alterations with co-occurring cell type signatures at single-cell resolution, applying it to glioma to identify functional immune and neuronal tumour cells and distinguish tumour from non-tumour cells with greater precision than existing annotation algorithms.
Single-cell transcriptomic analysis of mouse liver reveals nonparenchymal cells’ intricate responses to PCB126 exposure
Using single-cell RNA sequencing, researchers found that PCB126 exposure triggers cell-type-specific responses in mouse liver, activating the AhR signaling pathway mainly in endothelial cells while altering immune cell transcriptional profiles, revealing previously hidden heterogeneity in PCB toxicity.
Micro- and nanoplastic (MNPs) exposure at single-cell resolution impaired placental function and cellular dynamics
Researchers performed single-cell transcriptomic analysis of placentas from pregnant women exposed to micro- and nanoplastics, finding that MNP exposure altered trophoblast, macrophage, and fibroblast subpopulations, suggesting impaired placental function through disruption of cell communication and immune regulation.
Single-cell transcriptomic analysis reveals heterogeneity of the patterns of responsive genes and cell communications in liver cell populations of zebrafish exposed to polystyrene nanoplastics
Researchers used single-cell gene analysis to examine how polystyrene nanoplastics affect different cell types in zebrafish livers. They discovered that various liver cell populations responded to nanoplastic exposure in distinctly different ways, with some cell types showing more disruption to fat metabolism and stress response genes than others. The study reveals that nanoplastic toxicity in the liver is not uniform and that certain cell populations may be more vulnerable than previously understood.
Multidimensional analysis methods for flow cytometry : Pushing the boundaries
This thesis developed new methods for analyzing multidimensional flow cytometry data to better identify cell populations. While a bioinformatics and immunology paper, flow cytometry is also used in cutting-edge research to detect and quantify micro- and nanoplastics in biological fluids.
Nanoplastics: Immune Impact, Detection, and Internalization after Human Blood Exposure by Single‐Cell Mass Cytometry
Using a new single-cell detection method, researchers tracked how nanoplastics interact with 37 different types of human immune cells from blood samples. The nanoplastics were absorbed by and interfered with several immune cell types, particularly monocytes, macrophages, and dendritic cells. Mouse experiments confirmed the nanoplastics accumulated in immune cells in the liver, blood, and spleen, raising concerns about how plastic exposure could disrupt immune function.
Effective multi-modal clustering method via skip aggregation network for parallel scRNA-seq and scATAC-seq data
This paper presents a new computational method for analyzing single-cell genomic data by clustering cells based on both their gene expression and chromatin accessibility patterns. The technique uses a skip aggregation network to better integrate information from multiple data types. While not related to microplastics, this type of advanced analytical tool could potentially be applied to study how microplastic exposure affects gene expression at the single-cell level in human tissues.
Morphological profiling by high-throughput single-cell biophysical fractometry
Researchers developed a high-speed imaging technique called single-cell biophysical fractometry that measures the complex, irregular geometry of individual cells at a rate of about 10,000 cells per second. This tool can detect subtle structural differences between cancer cell subtypes and track how cells respond to drugs, offering a more detailed picture of cell health than standard methods.
4 Single cell RNA-seq samples exposed to nano plastic particles
Researchers used microfluidic chip-based single-cell RNA sequencing to profile the transcriptional responses of human peripheral blood immune cells exposed to carboxylated polystyrene nanoparticles of three sizes (40 nm, 200 nm, or a mixture), providing a cell-type-resolved view of nanoplastic effects on the immune system.
Food nutrition and toxicology targeting on specific organs in the era ofsingle-cell sequencing
This review examines how single-cell sequencing technologies can reveal organ-specific effects of food nutrients and toxicants, including contaminants like microplastics, by uncovering cellular heterogeneity and tissue-biased responses that traditional methods miss.
Single-Cell RNA Sequencing Profiling Cellular Heterogeneity and Specific Responses of Fish Gills to Microplastics and Nanoplastics
Using advanced single-cell sequencing, researchers mapped how individual cell types in fish gills respond differently to micro- and nanoplastic exposure. Microplastics mainly affected immune cells called macrophages, while nanoplastics primarily targeted T cells, and a structural cell type called fibroblasts was especially sensitive to microplastics. This detailed cell-level view reveals that plastic particles of different sizes can trigger distinct immune and tissue responses.
Quantitative Analysis of Nanoplastics in Single Cells by Subcellular Chromatography
This study developed a novel subcellular chromatography method capable of quantifying nanoplastic particles in different regions of individual living cells with femtolitre-to-attolitre precision. By directly sampling and separating intracellular cytoplasm, the technique revealed how nanoplastics distribute across different cellular compartments. This advance in analytical capability is important for understanding the subcellular fate of nanoplastics and the spatially specific toxicological mechanisms they may trigger inside cells.
RANKL/OPG axis as a therapeutic target for microplastic-induced bone loss: Mechanistic insights from transcriptomic and functional validation
This study found microplastic deposits in human bone tissue and showed that MPs disrupt bone metabolism by altering the RANKL/OPG signaling axis, a key regulator of bone remodeling. Transcriptomic and functional analyses identified therapeutic target pathways that could potentially protect against microplastic-induced bone loss.
Exploring immune responses of microplastics exposure using high-dimensional spectral flow cytometry
Researchers used high-dimensional spectral flow cytometry to profile immune cell responses in animals exposed to micro- and nanoplastics, detecting changes across multiple immune cell populations simultaneously. The approach revealed complex immune alterations that conventional methods would not capture.
Learning Single‐Cell Distances from Cytometry Data
This computational paper developed machine learning methods to measure distances between individual cells in flow cytometry data. While a bioinformatics paper, the methodology is potentially applicable to automated classification of microplastic particles in environmental samples.
Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production
Researchers discovered that myeloid-biased multipotent progenitor cells (MPP3) in the bone marrow are functionally heterogeneous, with a distinct secretory subset that rapidly produces granulocyte and macrophage progenitors. This study provides new insights into how the blood system amplifies myeloid cell production on demand through specialized progenitor cell populations.
4 Single cell RNA-seq samples exposed to nano plastic particles
This dataset entry corresponds to single-cell RNA sequencing data from human peripheral blood cells exposed to polystyrene nanoparticles (40 nm, 200 nm, and combined) to characterize size-dependent transcriptional responses in immune cell populations.
Single-cell transcriptome analysis of liver immune microenvironment changes induced by microplastics in mice with non-alcoholic fatty liver
Using advanced single-cell analysis, researchers showed that microplastics worsened non-alcoholic fatty liver disease in mice fed a high-fat diet by changing how immune cells behaved in the liver. Microplastic exposure amplified inflammatory responses and altered the communication between different liver cell types. This study is important because it reveals specific immune mechanisms by which microplastics could worsen liver disease, a condition already affecting roughly one in four adults worldwide.
DRscDB: A single-cell RNA-seq resource for data mining and data comparison across species
This paper describes a new database for analyzing single-cell gene expression data across different animal species including fruit flies. This genomics database tool is unrelated to microplastic research.
The impact of gut microbial signals on hematopoietic stem cells and the bone marrow microenvironment
This review explores how gut bacteria influence the production and development of blood cells in the bone marrow by sending chemical signals through microbial byproducts. While not directly about microplastics, the research is highly relevant because microplastics are known to disrupt gut bacteria communities. If microplastics alter the gut microbiome, they could indirectly affect blood cell production and immune function through this gut-bone marrow connection.
Nanoplastics: Immune Impact, Detection, and Internalization after Human Blood Exposure by Single‐Cell Mass Cytometry (Adv. Mater. 12/2025)
Researchers used single-cell mass cytometry to investigate how nanoplastics interact with human immune cells in blood samples. Nanoplastics were taken up by multiple immune cell subpopulations and affected cell viability and functionality, with the study cover image illustrating the findings from article number 2413413 in Advanced Materials.