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Papers
61,005 resultsShowing papers similar to Optical photothermal infrared spectroscopic assessment of microplastics in tissue models and non-digested human tissue sections
ClearLabel-free nano- and microplastics detection in mammalian tissue by photothermal infrared spectroscopy
Researchers applied optical photothermal infrared spectroscopy to detect and identify nano- and microplastics smaller than 1 µm in mammalian tissue sections without requiring labels or lengthy digestion protocols. The method successfully localized polystyrene particles in tissue samples with chemical specificity, offering a faster workflow for nanoplastic detection in biological matrices.
Detection of Unlabeled Micro- and Nanoplastics in Unstained Tissue with Optical Photothermal Infrared Spectroscopy
Researchers demonstrated that optical photothermal infrared spectroscopy can detect unlabeled micro- and nanoplastics as small as 250 nanometers in mammalian tissue samples without staining or labeling. The technique significantly outperformed traditional FTIR spectroscopy in spatial resolution and signal quality when imaging particles in complex biological matrices. The study also introduced a semi-automated machine learning analysis to speed up detection, offering a powerful new tool for studying nanoplastic accumulation in tissues.
Detection of Unlabeled Polystyrene Micro- and Nanoplastics in Mammalian Tissue by Optical Photothermal Infrared Spectroscopy
Researchers demonstrated that a new imaging technique called O-PTIR spectroscopy can detect unlabeled plastic particles as small as 200 nanometers inside mammalian tissues without damaging the samples. Combined with machine learning for faster analysis, this method significantly outperforms traditional infrared spectroscopy for finding nanoplastics in biological tissue. Better detection tools like this are essential for understanding how much plastic actually accumulates in human organs.
Unveiling Hidden Threats: Introduction of a Routine Workflow for Label-Free and Non-destructive Detection of Microplastics in Human FFPE Tissue Sections
Researchers developed a new workflow using mid-infrared photothermal microscopy to detect and identify microplastic particles directly in preserved human colon tissue sections. The method allows non-destructive, label-free identification of polymer types within tissue without special sample preparation. The study introduces a practical approach that could enable routine screening for microplastics in human tissues during standard medical examinations.
Characterization of microplastics in tap water by optical photothermal infrared
Researchers used optical photothermal infrared spectroscopy to characterize microplastics in tap water, identifying particles as small as a few micrometers that conventional FTIR techniques cannot resolve. The higher detection sensitivity revealed that microplastic concentrations in drinking water are likely underestimated by standard methods.
Label-Free Identification and Imaging of Microplastic and Nanoplastic Biouptake Using Optical Photothermal Infrared Microspectroscopy
Researchers developed a new imaging technique that can locate and identify microplastic and nanoplastic particles inside whole organisms without needing fluorescent labels. Using a method called optical photothermal infrared microscopy, they tracked polystyrene particles as small as 1 micrometer in roundworms. This tool could help scientists better understand how plastic particles are taken up by living things and where they accumulate in the body.
Development of a Binary Digestion System for Extraction Microplastics in Fish and Detection Method by Optical Photothermal Infrared
Researchers developed a two-step digestion method using nitric acid and hydrogen peroxide to extract microplastics from fish tissues, then detected the particles using optical photothermal infrared spectroscopy. This approach improves the ability to find microplastics in biological samples by efficiently removing complex fat-rich matrices that interfere with detection.
Method for label-free & non-destructive detection of microplastics in human formalin-fixed paraffin-embedded tissue sections
Researchers developed a new method to detect microplastic particles directly in preserved human colon tissue samples using advanced infrared microscopy, without destroying the tissue. They identified polyethylene, polystyrene, and PET particles within the tissue and observed signs of inflammation near the plastic particles, marking what may be the first workflow that combines microplastic detection with standard pathology analysis in human samples.
Photothermal Infrared Imaging of Nanoplastics in Human Cells with Nanoscale Resolution
Researchers demonstrated a new photothermal infrared imaging technique capable of detecting and localizing nanoplastics inside individual human cells at nanoscale resolution. The study found that polystyrene nanoparticles accumulated around cell nuclei, and that this advanced imaging approach overcomes the spatial resolution limitations of conventional infrared spectroscopy for tracking nanoplastics in biological tissues.
Label-free non-destructive spectroscopic detection of mixed microplastic uptake and differential effects on intestinal epithelial cells
Researchers used a specialized infrared spectroscopy technique to detect and identify real-world microplastics that had been internalized by human intestinal cells in the lab. They found that mixed microplastic exposures caused measurable changes in cellular biochemistry, even when individual plastic types showed limited effects. The study demonstrates a promising non-destructive method for tracking microplastics inside biological tissues and suggests that realistic mixtures of plastics may be more harmful than single types alone.
Advancements in optical techniques for direct identification and localization of micro- and nanoplastics in biological samples
Researchers reviewed advanced optical methods for directly detecting and localizing microplastics in biological tissues, highlighting techniques that can identify particles without extraction or digestion. Optical approaches including Raman mapping and coherent anti-Stokes Raman scattering allow spatial mapping of microplastics in tissue sections.
Characterization of microplastics in tap water by optical photothermal infrared
Researchers characterized microplastics in tap water using optical photothermal infrared spectroscopy, a technique that can identify particles smaller than 10 micrometers with high chemical specificity. The method detected a broader range of particle sizes than conventional FTIR microscopy, revealing higher microplastic concentrations in tap water than previously reported.
Detection ofUnlabeled Polystyrene Micro- and Nanoplasticsin Mammalian Tissue by Optical Photothermal Infrared Spectroscopy
Researchers evaluated optical photothermal infrared (O-PTIR) spectroscopy for detecting unlabeled polystyrene micro- and nanoplastics down to 200 nm in mammalian kidney tissues and 3D cell cultures. O-PTIR outperformed conventional FTIR in spatial resolution and signal-to-noise ratio, and machine learning accelerated particle detection with minimal human error.
PhotothermalInfrared Imaging of Nanoplastics in HumanCells with Nanoscale Resolution
Researchers used photothermal infrared imaging with nanoscale resolution to detect and localize polystyrene nanoparticles inside individual human fibroblast and glioblastoma cells, overcoming the size limitation of conventional FTIR and enabling sub-100 nm nanoplastic localization in cells.
Chemical characterization of microplastics from biosolids: a comparison of FTIR and O-PTIR microspectroscopy
Researchers compared conventional FTIR microspectroscopy with the emerging Optical Photothermal Infrared (O-PTIR) technique for chemical characterization and polymer-type identification of microplastics extracted from biosolids, finding that O-PTIR's submicron resolution and artifact-free spectra offer advantages over traditional methods.
Optical photothermal infrared spectroscopy with simultaneously acquired Raman spectroscopy for two-dimensional microplastic identification
Researchers demonstrated that optical photothermal infrared spectroscopy combined with simultaneous Raman acquisition enables more reliable two-dimensional microplastic identification, overcoming limitations of individual FTIR or Raman techniques alone.
Analysing micro- and nanoplastics with cutting-edge infrared spectroscopy techniques: a critical review
This review evaluates cutting-edge infrared spectroscopy techniques for detecting and analyzing micro- and nanoplastics in environmental and food samples. Better detection methods are crucial for understanding human exposure because they allow scientists to measure smaller particles more accurately, including nanoplastics that are small enough to cross biological barriers and accumulate in human tissues.
Raman microspectroscopy and laser-induced breakdown spectroscopy for the analysis of polyethylene microplastics in human soft tissues
Researchers developed a combined technique using Raman microspectroscopy and laser-based analysis to detect polyethylene microplastics in human soft tissue samples. The method can identify both the plastic polymer and any associated inorganic elements in tissue. This kind of detection tool is important for understanding whether microplastics accumulate in specific human organs and what health effects they might have.
Identifying Microplastics in Laboratory and Atmospheric Aerosol Mixtures via Optical Photothermal Infrared and Raman Microspectroscopy
Researchers developed optical photothermal infrared spectroscopy methods to identify microplastics in both laboratory-prepared and real atmospheric aerosol samples, demonstrating the technique's ability to distinguish plastic particles from other aerosol components in complex air quality monitoring contexts.
Machine learning powered framework for detection of micro- and nanoplastics using optical photothermal infrared spectroscopy
A machine learning framework was developed to detect and classify micro- and nanoplastics using optical photothermal infrared spectroscopy, addressing the lack of standardized detection methods in the field. The approach improves accuracy and consistency in identifying plastic particles, potentially enabling better monitoring of environmental and human health risks.
Set up and validation of a method to analyse microplastics in stool and small intestine samples
Researchers developed and validated practical methods for extracting and identifying microplastics from human stool samples and pig intestinal tissue. Using gentle chemical and enzyme-based digestion followed by infrared spectroscopy, they successfully detected multiple polymer types including polyethylene, polypropylene, and polystyrene, providing tools for studying microplastic exposure in the human digestive system.
Evidence of small microplastics (<100 μm) ingestion by Pacific oysters (Crassostrea gigas): A novel method of extraction, purification, and analysis using Micro-FTIR
Researchers developed a novel extraction, purification, and micro-FTIR analysis method to detect small microplastics under 100 micrometers in Pacific oysters (Crassostrea gigas), confirming ingestion of these smaller particles and finding that existing methods routinely miss this size fraction due to inadequate tissue digestion protocols.
Morphological and chemical characterization of nanoplastics in human tissue
Researchers developed methods to visualize and chemically characterize nanoplastics that have accumulated in human tissue samples. They were able to identify plastic particles smaller than one micrometer within tissue using advanced microscopy and spectroscopy techniques. The study provides some of the first direct evidence of nanoscale plastic accumulation in the human body, which is essential for designing future health effects research.
Using Infrared Photothermal Heterodyne Imaging to Characterize Micro- and Nanoplastics in Complex Environmental Matrices
Researchers introduced infrared photothermal heterodyne imaging (IR-PHI) as a 300 nm resolution technique for identifying and quantifying micro- and nanoplastics in complex environmental matrices, demonstrating its application to nylon tea bag leachates and sediment samples.