We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
61,005 resultsShowing papers similar to Mapping the Metabolic Characteristics and Perturbation of Adult Casper Zebrafish by Ambient Mass Spectrometry Imaging
ClearQuantitative monitoring of microplastics and lipid metabolism in live zebrafish via hyperspectral stimulated Raman scattering microscopy
Researchers used spectral focusing hyperspectral stimulated Raman scattering (SRS) microscopy to longitudinally monitor microplastic uptake, size-dependent organ accumulation, and lipid metabolic changes in live zebrafish during development. They found that microplastic exposure disrupted hepatic lipid metabolism and energy homeostasis, with the SRS imaging approach enabling real-time, label-free tracking of microplastics and associated biochemical changes in living organisms.
Mass spectrometry imaging enables detection of MPs and their effects in Daphnia magna following acute exposure
Researchers used an advanced imaging technique called mass spectrometry imaging to track where microplastics accumulate inside water fleas after short-term exposure. They found that the tiny organisms ingested microplastics that concentrated in their gut, and the exposure altered their lipid metabolism. The technique offers a new way to visualize exactly where microplastics end up in small aquatic organisms and what biochemical changes they cause.
MALDI mass spectrometry imaging workflow for the aquatic model organisms Danio rerio and Daphnia magna
Researchers developed a detailed imaging technique using mass spectrometry to map the location of lipids (fats) throughout the bodies of zebrafish and water fleas, two key species used in pollution studies, providing a new tool to detect how environmental contaminants disrupt fat metabolism at the tissue level.
Acute exposure to microplastics induces metabolic disturbances and gut dysbiosis in adult zebrafish (Danio rerio)
Researchers exposed adult zebrafish to polyethylene and polyester microplastics and used untargeted metabolomics and gut microbiome analysis to assess the effects. The study found that acute microplastic exposure caused significant metabolic disturbances and gut dysbiosis, altering key metabolites involved in lipid and amino acid metabolism.
Quantitative assessment and monitoring of microplastics and nanoplastics distributions and lipid metabolism in live zebrafish using hyperspectral stimulated Raman scattering microscopy
Researchers developed a new imaging technique to watch microplastics and nanoplastics accumulate in live zebrafish in real time, without needing dyes or labels. They found that these tiny plastic particles built up in the fish's digestive system and disrupted fat metabolism, providing direct visual evidence of how micro- and nanoplastics can interfere with basic biological processes.
Particle size-dependent neurotoxicity of microplastics in zebrafish (Danio rerio): Spatially resolved lipidomics links metabolic dysregulation to neurological disorders
Researchers exposed zebrafish to polypropylene microplastics of different sizes and used spatial lipidomic imaging to show size-dependent disruptions in brain lipid metabolism, linking smaller particles to greater neurological disruption and identifying specific lipid dysregulation patterns.
Liver Metabolic Dysregulation Induced by Polypropylene Nano- and Microplastics in Nile Tilapia Using Internal Extractive Electrospray Ionization Mass Spectrometry
Researchers exposed Nile tilapia fish to polypropylene nano- and microplastics and analyzed changes in liver metabolism using advanced mass spectrometry. They identified 46 metabolites that were significantly altered, including phospholipids, amino acids, and energy-related compounds, indicating disrupted liver function. The study suggests that polypropylene plastic particles can cause measurable metabolic disturbances in fish even without obvious visible harm.
Chronic Exposure of Adult Zebrafish to Polyethylene and Polyester-based Microplastics: Metabolomic and Gut Microbiome Alterations Reflecting Dysbiosis and Resilience
Researchers exposed adult zebrafish to polyethylene and polyester microplastics at environmentally relevant concentrations and found significant disruptions to metabolic pathways and gut microbiome composition. Polyethylene primarily affected cell membrane compounds and inflammation-related metabolites, while polyester altered lipid metabolism and gut bacterial interactions. The study reveals that chronic microplastic exposure can cause subtle but meaningful shifts in fish metabolism and gut health, even at low concentrations.
Qualitative and quantitative analysis of accumulation and biodistribution of polystyrene nanoplastics in zebrafish (Danio rerio) via artificial freshwater
Researchers developed MALDI-TOF mass spectrometry methods to accurately track polystyrene nanoplastic accumulation and biodistribution across zebrafish tissues after waterborne exposure, enabling precise quantitative analysis of nanoplastic uptake.
Effects on Zebrafish of Chemical Contaminants and Additives Present in Microplastics
Researchers fed zebrafish for 60 days on diets containing 10% environmental microplastics collected from beaches in Lanzarote and Tenerife, alongside clean pellet and control groups, then analyzed chemical contaminants in tissues by liquid chromatography coupled to high-resolution mass spectrometry. Results confirmed bioaccumulation of plastic additives and chemical contaminants in zebrafish tissues over time, with plastic synthesizers reaching the highest tissue concentrations followed by plasticizers.
Integrating laboratory and field data to evaluate the effects of experimental microplastic exposure on Acanthogobius flavimaus
Researchers integrated laboratory metabolomics experiments with field metabolomics data from estuarine gobies (Acanthogobius flavimanus) to assess whether environmental microplastic levels affect fish metabolism. Field fish showed metabolic changes consistent with those observed in laboratory MP-exposed individuals, suggesting that current environmental concentrations are biologically relevant.
Accumulation and Distribution of Fluorescent Microplastics in the Early Life Stages of Zebrafish
Researchers tracked the accumulation and distribution of fluorescent microplastics in early life stages of a freshwater organism, finding that microplastics were taken up and distributed across body tissues. The results help explain how microplastics accumulate in young aquatic organisms and potentially affect their development.
Polystyrene microplastic exposure disturbs hepatic glycolipid metabolism at the physiological, biochemical, and transcriptomic levels in adult zebrafish
Researchers exposed adult zebrafish to polystyrene microplastics for 21 days and examined effects on liver metabolism at multiple biological levels. The study found that microplastic exposure caused significant decreases in body weight and disrupted glycolipid metabolism, with reduced levels of key metabolic enzymes and gene expression changes in the liver. Transcriptomic analysis confirmed widespread downregulation of genes related to fatty acid, amino acid, and carbon metabolism.
Uptake, bioaccumulation, biodistribution and depuration of polystyrene nanoplastics in zebrafish (Danio rerio)
Researchers used advanced mass spectrometry to track how polystyrene nanoplastics accumulate in and are cleared from zebrafish tissues over time. The nanoplastics concentrated most in the intestine, liver, and gills, with only partial clearance after the exposure ended. This study provides important data on how persistent nanoplastics can be in living organisms, which helps scientists better assess the long-term risks of plastic particle exposure.
Comparison of metabolome profiles in zebrafish (Danio rerio) intestine induced by polystyrene microplastics with different sizes
Researchers compared metabolic profiles in zebrafish intestines after exposure to polystyrene microplastics of different sizes, finding that smaller particles caused more severe metabolic disruption including altered lipid metabolism and amino acid pathways in a size-dependent manner.
A Review of Liquid Chromatography-Mass Spectrometry Strategies for the Analyses of Metabolomics Induced by Microplastics
This review summarized liquid chromatography-mass spectrometry strategies for analyzing metabolomic changes induced by microplastic exposure, covering analytical approaches for understanding how microplastics disrupt metabolic pathways in living organisms.
Effects on immunity of exposure to microplastics in adult zebrafish
Adult zebrafish exposed to microplastics showed changes in liver gene expression, gut and gill tissue damage, and altered swimming behavior, indicating that microplastic exposure triggers multiple biological stress responses. The study highlights the relevance of zebrafish as a model for assessing microplastic toxicity.
Revealing Metabolic Dysregulation Induced by Polypropylene Nano- and Microplastics in Nile Tilapia via Noninvasive Probing Epidermal Mucus
Using a noninvasive needle-based sampling technique paired with mass spectrometry, researchers detected metabolic disruptions in the skin mucus of Nile tilapia exposed to polypropylene micro- and nanoplastics.
Combined effects of high-fat diet and polystyrene microplastic exposure on microplastic bioaccumulation and lipid metabolism in zebrafish
Researchers studied how a high-fat diet combined with polystyrene microplastic exposure affects zebrafish, finding that obese fish accumulated significantly more microplastics in their tissues. The high-fat diet disrupted lipid metabolism and created conditions that increased microplastic retention in the body. This suggests that diet and body fat levels may influence how much microplastic accumulates in living organisms, with potential implications for human health.
Effects of polystyrene microplastics acute exposure in the liver of swordtail fish (Xiphophorus helleri) revealed by LC-MS metabolomics
Researchers used metabolomics to investigate the effects of acute polystyrene microplastic exposure on swordtail fish livers. The study found that microplastic exposure caused significant alterations in metabolic pathways related to amino acid metabolism, lipid metabolism, and energy production, indicating broad metabolic disruption even after short-term exposure.
A metabolomics perspective on the effect of environmental micro and nanoplastics on living organisms: A review
This review examines how scientists use metabolomics, the study of small molecules produced by cellular processes, to understand the toxic effects of microplastics and nanoplastics on living organisms. The research shows that these plastic particles disrupt metabolism in consistent ways across species, affecting energy production, fat processing, and amino acid pathways. These shared metabolic disruptions across different organisms suggest that microplastics could cause similar metabolic problems in humans.
Impact of polyvinyl chloride microplastic exposure on the hepatopancreas metabolism of Pinctada fucata martensii: Insights from metabolomics
Researchers exposed pearl oysters to PVC microplastics and used metabolomics to track changes in the animals' liver-like organ. They found that microplastic exposure disrupted amino acid and lipid metabolism, with signs of potential neurotoxicity and oxidative damage, demonstrating that common plastic pollutants can meaningfully alter the biological processes of shellfish.
Zebrafish exposure to high-density polyethylene and polystyrene microplastics: effects on liver transcriptome and gastrointestinal histology
This study used proteomics — the analysis of all proteins expressed by cells — to identify how zebrafish respond to exposure to high-density polyethylene and polystyrene microplastics, finding disruption of proteins involved in metabolism, oxidative stress, and immune defense. The protein-level analysis complements genomic approaches and reveals the biological mechanisms underlying microplastic toxicity in fish.
Quantitative Tracking of Nanoplastic Uptake and Distributionin Zebrafish by Single-Particle Inductively Coupled Plasma Mass Spectrometry
Researchers developed a framework using europium-doped polystyrene nanoplastics as tracers, combined with single-particle inductively coupled plasma mass spectrometry, to quantitatively track nanoplastic uptake and distribution in zebrafish at the single-particle level. This method enabled real-time, size-resolved tracking of nanoplastics accumulating in different fish organs over time.