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61,005 resultsShowing papers similar to Bridging systems biology and tissue engineering: Unleashing the full potential of complex 3D in vitro tissue models of disease
ClearThe new era of cardiovascular research: revolutionizing cardiovascular research with 3D models in a dish
This review explores how three-dimensional cell and tissue models grown in the laboratory are transforming cardiovascular research. Researchers describe advances in organoids, heart-on-chip devices, and 3D-printed tissue constructs that better mimic human heart and blood vessel biology than traditional animal models. The study highlights how these new models could accelerate the discovery of treatments for heart disease while reducing reliance on animal testing.
Challenges and opportunities for digital twins in precision medicine from a complex systems perspective
Researchers argue that digital twins — virtual computer models of individual patients — could transform personalized medicine by simulating how a person's biology responds to different treatments. Combining AI with detailed biological models allows doctors to test therapeutic strategies virtually before applying them in real clinical settings.
Transcending toward Advanced 3D-Cell Culture Modalities: A Review about an Emerging Paradigm in Translational Oncology
This review described the shift from conventional 2D cell culture to advanced 3D models in cancer research, evaluating how spheroids, organoids, and microfluidic systems better replicate tumor biology and improve the translational relevance of drug screening studies.
Global trends and hotspots in research on organoids between 2011 and 2020: a bibliometric analysis
A bibliometric analysis of organoid research from 2011 to 2020 identified drug screening, disease modeling, and personalized medicine as the dominant themes, while highlighting reproducibility and functional maturity as ongoing limitations. The authors predicted that bioengineering strategies to overcome these limitations would become the next major focus of the field.
Human mini-brains for reconstituting central nervous system disorders
This review discussed advances in human brain organoids (mini-brains) for modeling central nervous system disorders, highlighting their potential to overcome limitations of animal models and accelerate drug development for neurological diseases.
Interaction between Macrophages and Nanoparticles: In Vitro 3D Cultures for the Realistic Assessment of Inflammatory Activation and Modulation of Innate Memory
This study examined how human monocytes and macrophages interact with engineered nanoparticles using in vitro 3D culture models that better replicate tissue conditions than standard 2D cultures. The findings provide a more realistic assessment of nanoparticle-triggered immune and inflammatory responses relevant to both safety evaluation and medical applications.
Multi-chamber cardioids unravel human heart development and cardiac defects
Researchers engineered a human cardioid platform that self-organizes into multi-chambered heart structures recapitulating all major embryonic compartments including left and right ventricles, atria, outflow tract, and atrioventricular canal. The platform enables direct study of genetic mutations and environmental factors including chemical exposures on human heart development in ways not possible with existing 2D or simpler 3D models.
Transforming Toxicity Assessment through Microphysiology, Bioprinting, and Computational Modeling
This review examines emerging alternatives to traditional animal-based toxicity testing, including microphysiology systems, bioprinted tissues, and computational models. Researchers found that these human cell-based platforms can better predict how chemicals and drugs affect human biology while also being more ethical and higher throughput. The study suggests these technologies could transform how chemical safety and drug development testing is conducted.
AI-Enhanced Patient-Derived Cancer Organoids: Integrating Machine Learning for Precision Oncology
This review explores how combining patient-derived cancer organoids with artificial intelligence enables more precise drug sensitivity predictions and biomarker discovery in oncology research. While not directly related to microplastic research, the study demonstrates how AI and advanced biological models can be integrated to analyze complex datasets. The approaches described may inform future methods for studying how environmental contaminants interact with human tissues.
Utilization of intestinal organoid models for assessment of micro/nano plastic-induced toxicity
This review examines the use of intestinal organoid models as a more physiologically accurate alternative to traditional cell cultures and animal experiments for studying micro- and nanoplastic toxicity. Researchers highlight that organoids can mimic the complex structure of intestinal tissue, providing better insight into how plastic particles affect the gut. The study suggests that while organoid-based research is still in its early stages, it holds significant promise for advancing our understanding of plastic-related health effects.
Organoids as a Tool for Assessing Drinking Water Safety and Guidelines Relevance
This review assessed the potential of organoids — three-dimensional tissue models derived from human cells — as tools for evaluating drinking water safety, particularly for contaminants like microplastics that conventional cell lines poorly model. Organoids offer greater tissue complexity and inter-individual variability, making them more realistic platforms for human health risk assessment.
In vivo , in vitro , and in silico toxicology studies of nanoplastics and their modeling
This in vivo, in vitro, and in silico study assessed nanoplastic toxicity through multiple complementary methods, finding concentration-dependent toxic effects on cellular and organismal endpoints and using computational modeling to predict interaction mechanisms relevant to nanoplastic risk assessment.
Advancing 3D printed microfluidics with computational methods for sweat analysis
This review explores advances in 3D-printed microfluidic devices combined with computational methods for non-invasive sweat analysis. The study highlights how sweat biomarkers correlate with bloodstream markers, and discusses the potential of portable, cost-effective platforms for health monitoring applications.
Advancing Microplastic and Nanoplastic Toxicity Assessment: Insights from Human Organoid Models
This review examines how human stem cell-derived organoids are being used to study the toxic effects of microplastics and nanoplastics on human tissues. Researchers found that organoid models of the gut, lung, brain, and other organs provide more human-relevant data than traditional animal testing for assessing plastic particle toxicity. The study suggests that organoid technology could significantly advance understanding of how microplastics affect human health at the tissue and organ level.
Deep learning-enabled Inference of 3D molecular absorption distribution of biological cells from IR spectra
Researchers built a deep learning computer model that can reconstruct the 3D internal structure and chemical makeup of tiny biological cells using only infrared light measurements. This near-real-time approach could speed up analysis of biological samples without physically slicing or destroying them.
Application of organoid technology in the human health risk assessment of microplastics: A review of progresses and challenges
This review examines how organoid technology -- miniature lab-grown versions of human organs made from stem cells -- can be used to study the health effects of microplastics more accurately than traditional animal testing. Organoids of the gut, lung, brain, liver, and other organs can better predict how microplastics affect human tissues, potentially accelerating our understanding of the real health risks these particles pose.
Neuropathogenesis-on-chips for neurodegenerative diseases
Researchers reviewed how miniaturized lab-on-a-chip devices that mimic brain tissue are being developed to study neurodegenerative diseases like Alzheimer's and Parkinson's, offering more realistic models than traditional animal tests. These microfluidic systems, combined with stem cells, could accelerate the discovery of new diagnostics and treatments for conditions that affect millions of people worldwide.
Everything You Want to Know About Coarse‐Graining and Never Dared to Ask: Macromolecules as a Key Example
This review explores coarse-graining simulation techniques that allow researchers to model larger and more complex molecular structures by reducing computational detail. The study discusses how these methods are becoming essential for designing innovative materials, including eco-friendly alternatives to traditional plastics, and for understanding large-scale biological molecular machines. The authors highlight the trade-offs between computational efficiency and molecular accuracy that researchers must navigate when selecting coarse-grained models.
Multi-cellular engineered living systems to assess reproductive toxicology
Researchers reviewed how multi-cellular engineered living systems — including organ-on-chip devices and organoids — are being used to model reproductive toxicology for chemicals and drugs, highlighting their advantages over animal models for studying the placenta, embryo development, and both male and female reproductive organs.
Toward Computational Accuracy in Realistic Systems to Aid Understanding of Field-Level Water Quality Issues
This perspective paper discusses the potential of computational chemistry to improve understanding of how pollutants behave in real-world water systems. Better computational models could help predict how microplastics and chemical contaminants interact and move through waterways. The paper is primarily a methodological discussion rather than a primary research study.
Human organoids to assess environmental contaminants toxicity and mode of action: towards New Approach Methodologies
This review explores how human organoids, miniature lab-grown organ models, can be used to test the toxicity of environmental contaminants including microplastics. These 3D tissue models offer a more accurate picture of how pollutants affect human cells than traditional lab tests, though more work is needed to simulate the chronic, low-dose exposures people actually experience.
The Need to Implement Innovative Technologies to Advance Research on the Biotoxicity of Micro- and Nanoplastics
This review examines the limitations of current animal models for studying the biotoxicity of micro- and nanoplastics and argues for the adoption of innovative technologies such as organoids, organ-on-chip platforms, and advanced imaging. It calls for mechanistic studies that move beyond descriptive toxicity characterisation.
Application of Computer Simulation Technology in Detection Model of Mycoplasma Pathogen Subtype
This paper developed a detection model for mycoplasma pathogen invasion in biological systems using deep learning techniques. The research is focused on pathogen detection and has limited direct relevance to microplastic pollution or human health.
Recent trends in bioartificial muscle engineering and their applications in cultured meat, biorobotic systems and biohybrid implants
Researchers reviewed the latest advances in engineering laboratory-grown muscle tissue, which has promising applications in cultured meat, soft robots, and medical implants — three fields that have largely worked in isolation despite sharing common challenges. Bringing these communities together could accelerate breakthroughs across all three industries.