We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
20 resultsShowing papers similar to Iron Oxide Nanoparticles: Selectively Targeting Melanoma Cells In Vitro by Inducing DNA Damage via H2AX Phosphorylation and Hindering Proliferation through ERK Dephosphorylation
ClearExploring Metal Nanoparticles Interaction with Cancer Cells
This paper is not relevant to microplastics research — it reviews the uses of metal nanoparticles in biomedical applications, particularly cancer treatment, and discusses their toxicity profiles.
How to Treat Melanoma? The Current Status of Innovative Nanotechnological Strategies and the Role of Minimally Invasive Approaches like PTT and PDT
This review summarizes advances in nanotechnology-based treatments for melanoma, including photothermal and photodynamic therapies using engineered nanoparticles as drug carriers and light absorbents. While nanoparticle-based therapies show promise for improving treatment outcomes, the environmental fate of these engineered nanomaterials remains a concern, as nanoparticles can behave similarly to microplastics when released into ecosystems.
Functionalized magnetic nanoparticles: Synthesis, characterization, catalytic application and assessment of toxicity
Researchers developed iron-based magnetic nanoparticles as catalysts that can rapidly break down bisphenol A (BPA) — a common plastic additive and endocrine disruptor — in water using a combination of low-dose hydrogen peroxide and UV light, achieving complete degradation in under 15 minutes. The treated water also showed reduced toxicity to human cancer cells, suggesting this approach could help remove persistent chemical pollutants from water supplies.
The influence of microplastic particles on the effectiveness of electrochemotherapy in breast cancer cells
Researchers examined whether microplastic particle exposure affects the effectiveness of electrochemotherapy in breast cancer cells, investigating whether MPs could alter cellular responses to the combined electroporation and chemotherapy treatment through inflammatory or oxidative stress mechanisms.
Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells
This review explores how reactive oxygen species (ROS) -- harmful molecules produced during abnormal cell metabolism -- can damage DNA and trigger cancer cell death, making ROS a potential target for cancer treatment. While not directly about microplastics, this is relevant because microplastic exposure is known to increase ROS production in human cells, which could contribute to DNA damage over time.
Bioeffects of Nanoplastics: DNA Damage and Mechanism
This review examines how nanoplastics, plastic particles smaller than one micrometer, can damage DNA in cells. The authors explain that nanoplastics may cause genetic damage through oxidative stress, inflammation, and direct interference with cellular processes, which raises concerns about potential long-term health effects including cancer risk.
Iron-Reduced Graphene Oxide Core–Shell Micromotors Designed for Magnetic Guidance and Photothermal Therapy under Second Near-Infrared Light
Researchers developed a novel iron-reduced graphene oxide core-shell micromotor designed for targeted photothermal therapy using second near-infrared light. The micromotor combines magnetic guidance with efficient light-to-heat conversion and demonstrated strong tumor-killing ability in laboratory experiments. While not focused on microplastics, the study advances micro-scale robotic technologies that have potential future applications in environmental remediation.
Nanoparticle delivery of TFOs is a novel targeted therapy for HER2 amplified breast cancer
Researchers engineered a nanoparticle drug delivery system that carries triple-helix DNA molecules (TFOs) directly to cancer cells that overexpress the HER2 protein, showing effective tumor suppression without significant toxicity in animal models. This targeted approach could offer a new treatment strategy for HER2-amplified breast cancers, which tend to be aggressive and hard to treat.
Reversing the immunosuppressive microenvironment with reduced redox level by microwave-chemo-immunostimulant Ce–Mn MOF for improved immunotherapy
Researchers developed a nanoparticle-based treatment that combines microwave energy, chemotherapy, and immune activation to reverse the protective environment that tumors create to hide from the immune system. In animal experiments, this combined approach significantly increased immune cell infiltration into tumors and improved the body's ability to fight cancer beyond the treated area.
Double-edged Sword Role of Iron-loaded Ferritin in Extracellular Vesicles
This review explores the dual role of iron-loaded ferritin in extracellular vesicles, discussing how excess cellular iron promotes Fenton reaction-driven oxidative DNA damage and cellular ferroptosis resistance, contributing to carcinogenesis.
Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment
This review covers advances in targeted drug delivery using nanotechnology, including nanoparticles and liposomes designed to release medications precisely where needed in the body. While focused on cancer treatment, the drug delivery technologies discussed are relevant to understanding how nanoscale plastic particles may also travel through the body and accumulate in specific tissues.
Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance
This review explores how nanotechnology is being used to overcome drug resistance in cancer treatment, using materials like carbon nanotubes, dendrimers, and liposomes to deliver drugs more precisely to tumors. While not directly about microplastics, the nanomaterial strategies discussed share relevance with understanding how nano-sized plastic particles interact with human cells and tissues.
Ferroptosis inhibition via the ROS-GPX4 axis drives microplastic-induced malignant progression of nasopharyngeal carcinoma
Researchers investigated how polystyrene microplastics promote malignant progression in nasopharyngeal carcinoma cells, finding that the plastics inhibit ferroptosis—an iron-dependent cell death pathway—via the ROS-GPX4 axis, thus allowing cancer cells to survive and proliferate. Blocking this anti-ferroptosis effect restored cancer cell death, suggesting that targeting the ferroptosis pathway could counteract microplastic-driven tumor progression.
Microplastics and Nanoplastics in Cancer Progression: Biology and Public Health
This review examines emerging evidence that microplastics and nanoplastics may contribute to cancer-related processes by crossing biological barriers and accumulating in tissues. The study highlights that these particles can cause oxidative stress, inflammation, DNA damage, and barrier dysfunction at the cellular level, and may promote tumor-supporting processes including angiogenesis and immune evasion.
Toxicity of metal-based nanoparticles: Challenges in the nano era
This review covers the toxic effects of metal-based nanoparticles on human health, including how they cause oxidative stress, inflammation, DNA damage, and organ dysfunction. While focused on engineered nanoparticles rather than microplastics directly, the toxicity pathways described overlap significantly with those triggered by nanoplastic exposure. Understanding these shared mechanisms helps explain how nano-scale particles of any kind, including nanoplastics, may harm the body.
Cytotoxicity of Nanoparticles Used in Cosmetic Industries: An In-depth Insight
This review examined the cytotoxicity of nanoparticles used in cosmetic sunscreens, including titanium dioxide and zinc oxide, finding that while these particles provide effective UV protection, their nanoscale form raises concerns about skin penetration and potential cellular toxicity.
Polystyrene Microplastics Induce Radiotherapy Resistance in Lung Cancer by Suppressing Ferroptosis Through NF-κB Activation
Researchers found that polystyrene microplastics impaired radiotherapy efficacy in lung cancer cells by suppressing ferroptosis—a form of iron-dependent cell death—through NF-κB activation, providing the first evidence that microplastics may contribute to cancer therapy resistance.
Recent Advances of Magnetite (Fe3O4)-Based Magnetic Materials in Catalytic Applications
This review covers how magnetite (iron oxide) nanomaterials are being used in environmental cleanup, including removing pollutants from water, and in medical applications like cancer treatment. The magnetic properties of these materials make them easy to recover and reuse, which is relevant to microplastic pollution because magnetic separation is one promising method for filtering microplastics out of water.
Micro and nanoplastics in human carcinogenesis: Insights from in vitro studies
This narrative review compiles in vitro evidence on the carcinogenic effects of micro- and nanoplastics across multiple cancer types, examining mechanisms including oxidative stress, DNA damage, immune dysregulation, and epigenetic changes identified in cell culture experiments.
Insights into the potential carcinogenicity of micro- and nano-plastics.
This review examined existing evidence on the carcinogenic potential of micro- and nano-plastics, finding studies demonstrating genotoxicity, oxidative DNA damage, disruption of cell signaling, and tumor-promoting effects, while noting that direct human carcinogenicity data remain limited and mechanistic pathways require further investigation.