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Nanoparticle delivery of TFOs is a novel targeted therapy for HER2 amplified breast cancer
Summary
Researchers engineered a nanoparticle drug delivery system that carries triple-helix DNA molecules (TFOs) directly to cancer cells that overexpress the HER2 protein, showing effective tumor suppression without significant toxicity in animal models. This targeted approach could offer a new treatment strategy for HER2-amplified breast cancers, which tend to be aggressive and hard to treat.
In this study, we designed nano-drug TFO@ZW-128, which has proven effective and non-toxic in targeted therapy for ectopic HER2-expressing tumors.
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