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61,005 resultsShowing papers similar to Examining the Pathogenesis of MAFLD and the Medicinal Properties of Natural Products from a Metabolic Perspective
ClearMicroplastics in metabolic dysfunction-associated steatotic liver disease: An emerging threat to liver health
This review examined emerging evidence linking microplastic exposure to the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD). The authors found that microplastics detected in liver tissue can exacerbate hepatic inflammation, lipid accumulation, and oxidative stress through multiple mechanisms, adding a novel environmental risk factor to MASLD pathogenesis.
Microplastics and nanoplastics: Emerging drivers of hepatic pathogenesis and metabolic dysfunction
This review examines emerging evidence linking micro- and nanoplastic exposure to liver disease, including metabolic dysfunction-associated liver disease, cirrhosis, and liver cancer. Researchers found that these particles may contribute to liver damage through oxidative stress, inflammation, and disruption of metabolic pathways. The study highlights the need for further research into how environmental plastic contamination may be influencing the rising rates of liver disease worldwide.
Adipose tissue as target of environmental toxicants: focus on mitochondrial dysfunction and oxidative inflammation in metabolic dysfunction-associated steatotic liver disease
This review examines how environmental toxicants, including micro and nanoplastics, target fat tissue and contribute to metabolic diseases like obesity, diabetes, and fatty liver disease. These pollutants disrupt mitochondria (the energy-producing parts of cells) and trigger a cycle of oxidative stress and inflammation that damages both fat tissue and the liver. The findings suggest that microplastic exposure could be one of several environmental factors contributing to the rising rates of metabolic disease worldwide.
Are Ingested or Inhaled Microplastics Involved in Nonalcoholic Fatty Liver Disease?
This review explored the potential connection between microplastic exposure through ingestion and inhalation and nonalcoholic fatty liver disease, which has become a leading cause of chronic liver injury. The study discusses how dietary and environmental microplastic exposure could potentially influence liver health through mechanisms including inflammation and endocrine disruption, though further research is needed to establish definitive links.
Overview of the hazardous impacts of metabolism-disrupting chemicals on the progression of fatty liver diseases.
This review examined how metabolism-disrupting chemicals (MDCs)—including bisphenol A and phthalates from plastics—promote the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD). MDC exposure was found to impair liver lipid homeostasis and contribute to the global rise in fatty liver disease.
Non-parenchymal cells: key targets for modulating chronic liver diseases
This review examines how specialized non-parenchymal cells in the liver drive chronic liver diseases like fatty liver disease, fibrosis, and cirrhosis through inflammation and scarring. While not directly about microplastics, these are the same cell types and disease pathways that microplastics and nanoplastics have been shown to activate when they accumulate in liver tissue. Understanding these mechanisms helps explain how environmental pollutants like microplastics could contribute to the growing burden of chronic liver disease.
Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions
This review summarizes what scientists know about how micro- and nanoplastics affect the liver, which is one of the first organs exposed because it processes everything absorbed from the gut. The particles trigger oxidative stress, disrupt energy metabolism, cause cell death, and promote inflammation, and may contribute to conditions like fatty liver disease and liver fibrosis. The paper also highlights how plastics can disturb the gut microbiome, which communicates with the liver through the gut-liver axis and may amplify liver damage.
Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver–Eye Axis
This review explores the connection between microplastic exposure and liver disease through the lens of the liver-eye axis, a physiological link between ocular and hepatic health. Researchers discuss how microplastics can enter the body through the eyes and respiratory tract, accumulate in the liver, and potentially contribute to chronic liver conditions through oxidative damage. The study highlights the need for further research into whether microplastic buildup in the liver is a cause or consequence of liver disease.
Links between fecal microplastics and parameters related to metabolic dysfunction-associated steatotic liver disease (MASLD) in humans: An exploratory study
In this exploratory human study, researchers found links between microplastics in people's stool samples and markers of metabolic liver disease (MASLD). Participants with liver disease had different types and amounts of fecal microplastics compared to healthy individuals, along with changes in gut bacteria and liver gene expression. While the study is small, it provides early evidence that microplastic exposure in humans may be connected to liver health problems.
Chronic Nanoplastic Exposure Promotes the Development and Progression of Metabolic Dysfunction‐Associated Steatotic Liver Disease
This study found that chronic exposure to nanoplastics promotes the development and worsening of metabolic dysfunction-associated steatotic liver disease (formerly known as fatty liver disease). Nanoplastics appear to increase vulnerability to liver disease progression. The finding is concerning because fatty liver disease is already widespread, and everyday nanoplastic exposure through food and water could be making it worse.
Table 1_Microplastics in focus: a silent disruptor of liver health- a systematic review.docx
This systematic review of 25 studies found that micro- and nanoplastics can damage liver cells by causing oxidative stress, inflammation, and disrupting how the liver processes fats. These findings suggest that plastic particles small enough to reach the liver could contribute to liver disease, though more human studies are needed.
Chronic Nanoplastic Exposure as a Novel Risk Amplifier for MASLD Progression
This study examines the potential for chronic nanoplastic exposure to amplify the progression of metabolic dysfunction-associated steatotic liver disease. The research explores how persistent nanoplastic exposure may act as a novel risk factor that worsens liver disease outcomes. The findings highlight growing concern about the intersection of plastic pollution and metabolic health conditions.
The nexus of environmental endocrine-disrupting chemical exposure and metabolic dysfunction-associated steatotic liver disease: An emerging public health challenge
This review examines evidence that chronic low-dose exposure to endocrine-disrupting chemicals, including micro- and nanoplastics, may be an underappreciated factor driving the global rise of metabolic liver disease. Researchers found that these pollutants can promote liver fat accumulation, inflammation, and scarring by disrupting hormone signaling, gut health, and mitochondrial function. The study suggests that environmental chemical exposures should be considered alongside diet and lifestyle when assessing liver disease risk.
Molecular LandscapeRemodeling Unravels the Cross-Linksof Microplastics-Induced Lipidomic Fluctuations,Nutrient Disorders and Energy Disarrangements
Researchers examined polypropylene microplastic retention in mouse liver using lipidomics and transcriptomics, finding that chronic exposure disrupted lipid metabolism, cholesterol turnover, and antioxidant defense, with high-dose treatment causing regional liver fibrosis.
Exposure to microplastics and liver oncogenesis: A comprehensive review on molecular mechanisms and pathogenic pathways
Researchers reviewed mechanisms by which microplastic exposure may promote liver cancer, identifying oxidative stress, mitochondrial dysfunction, inflammatory signaling, and epigenetic disruption as key pathways, while noting that microplastics can also carry heavy metals and organic pollutants that synergistically amplify hepatotoxic and carcinogenic risk.
Molecular Landscape Remodeling Unravels the Cross-Links of Microplastics-Induced Lipidomic Fluctuations, Nutrient Disorders and Energy Disarrangements
Researchers fed mice polypropylene microplastics chronically and used lipidomics and transcriptomics to show that microplastics accumulated in the liver and disrupted lipid metabolism, cholesterol homeostasis, and redox balance, with high doses causing fibrotic liver changes.
Molecular LandscapeRemodeling Unravels the Cross-Linksof Microplastics-Induced Lipidomic Fluctuations,Nutrient Disorders and Energy Disarrangements
This study examined how polypropylene microplastics accumulate in and damage the mouse liver, using integrated lipidomics and transcriptomics to map the molecular landscape of microplastic-induced lipid disruption and metabolic dysfunction.
Hepatotoxic Mechanisms of Micro- and Nanoplastics in Animal Models: A Scoping Review with Human Health Implications
This scoping review examines hepatotoxic mechanisms of micro- and nanoplastics in animal models, identifying oxidative stress, inflammation, lipid peroxidation, and epigenetic alterations as the primary pathways through which plastic particles damage liver tissue.
Plastic compounds and liver diseases: Whether bisphenol A is the only culprit
This review looks at how plastic-derived chemicals beyond just bisphenol A (BPA) can damage the liver, particularly by contributing to non-alcoholic fatty liver disease (NAFLD). The authors find that microplastics, nanoplastics, and various bisphenol alternatives all show links to liver problems, suggesting that the full range of plastic pollutants -- not just BPA -- may pose a greater threat to liver health than previously understood.
Emerging threat of environmental microplastics: A comprehensive analysis of hepatic metabolic dysregulation and hepatocellular damage (Review)
This review summarizes existing research on how microplastics damage the liver, which is a key organ for filtering toxins from the body. Studies show that microplastics can cause liver tissue damage, trigger cell death, and disrupt fat metabolism, with smaller particles and longer exposure causing worse effects. The findings highlight the liver as a particularly vulnerable organ because it accumulates microplastics that enter the body through food and water.
Nanoplastics and Microplastics May Be Damaging Our Livers
This systematic review summarizes research on how micro- and nanoplastics may damage the liver. Since the liver is the body's main detoxification organ, it plays a key role in processing plastic particles that enter the body through food, water, and air, and the evidence suggests these particles can cause inflammation, oxidative stress, and other liver problems.
Nanoplastics and MASLD : Unveiling Interorgan Crosstalk and Environmental Modulators
This brief editorial discusses the emerging connection between nanoplastic exposure and metabolic-associated steatotic liver disease (MASLD), a condition involving fat buildup in the liver. It highlights how nanoplastics may act as environmental triggers that affect the liver through interactions with the gut and other organs. As MASLD rates rise globally, understanding whether plastic pollution contributes to liver disease is an important emerging area of research.
Molecular Mechanisms of Phthalate-Induced Hepatic Injury and Amelioration by Plant-Based Principles
This review examines how phthalates, chemicals commonly added to plastics to make them flexible, damage the liver through oxidative stress, inflammation, and disruption of normal cell signaling. People are exposed to phthalates through air, water, food, and skin contact, and the liver bears the greatest burden as the primary organ for processing these chemicals. The findings are directly relevant to microplastics because phthalates can leach from plastic particles inside the body, making microplastic exposure a potential delivery route for these liver-damaging chemicals.
Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution
This review explores how environmental pollutants, including microplastics and endocrine-disrupting chemicals, may contribute to non-alcoholic fatty liver disease, with differences between men and women. The authors argue that diet and lifestyle changes alone cannot explain the rapid global rise in liver disease, and that chemical exposures deserve more attention. The study highlights how pollutants that disrupt hormones and metabolism could be an underrecognized factor in liver health.