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Nanoplastics and MASLD : Unveiling Interorgan Crosstalk and Environmental Modulators
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This brief editorial discusses the emerging connection between nanoplastic exposure and metabolic-associated steatotic liver disease (MASLD), a condition involving fat buildup in the liver. It highlights how nanoplastics may act as environmental triggers that affect the liver through interactions with the gut and other organs. As MASLD rates rise globally, understanding whether plastic pollution contributes to liver disease is an important emerging area of research.
The authors have nothing to report.
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Microplastics in metabolic dysfunction-associated steatotic liver disease: An emerging threat to liver health
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This review examined emerging evidence linking microplastic exposure to the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD). The authors found that microplastics detected in liver tissue can exacerbate hepatic inflammation, lipid accumulation, and oxidative stress through multiple mechanisms, adding a novel environmental risk factor to MASLD pathogenesis.
Chronic Nanoplastic Exposure as a Novel Risk Amplifier for MASLD Progression
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This study examines the potential for chronic nanoplastic exposure to amplify the progression of metabolic dysfunction-associated steatotic liver disease. The research explores how persistent nanoplastic exposure may act as a novel risk factor that worsens liver disease outcomes. The findings highlight growing concern about the intersection of plastic pollution and metabolic health conditions.
Letter to the Editor: Microplastics as promoters of metabolic dysfunction-associated steatotic liver disease: Mechanistic insights and implications
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Tiny plastic particles found in our bodies—including the liver—may worsen fatty liver disease by disrupting how liver cells manage fat, handle stress, and clean out damaged parts, according to this commentary on existing lab and animal research. Since fatty liver disease is already the most common chronic liver condition worldwide and can lead to liver cancer, these findings raise concerns about how everyday plastic exposure might be affecting our health, though more human studies are needed to confirm the connection.
Exploring the Classic and Novel Pathogenetic Insights of Plastic Exposure in the Genesis and Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
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This review examined how micro/nanoplastic (MNP) exposure contributes to the genesis and progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), the predominant liver disease in industrialized countries. Oral MNP exposure impacts the gut-liver axis, promotes steatosis through metabolic dysfunction and inflammation, and plastic additives like BPA act as exogenous factors that may trigger trained immunity pathways worsening MASLD.
Response to Letter to the Editor: “Chronic Nanoplastic Exposure as a Novel Risk Amplifier for MASLD Progression”
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This paper is a response to a letter to the editor concerning the hypothesis that chronic nanoplastic exposure may act as a novel risk amplifier for metabolic dysfunction-associated steatotic liver disease (MASLD) progression, addressing methodological and interpretive points raised by correspondents.
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