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61,005 resultsShowing papers similar to Green tea extracts rich in epicatechins inducing aggregation and inhibiting absorption of amine surface functionalized polystyrene microplastics in vitro mimick system
ClearCharacterization of the intestinal transport mechanism of polystyrene microplastics (MPs) and the potential inhibitory effect of green tea extracts on MPs intestinal absorption
Researchers studied how polystyrene microplastics of different sizes and charges are transported across intestinal cells, and whether green tea extracts can reduce that absorption. The study suggests that green tea extracts may help strengthen the intestinal barrier, reduce microplastic transport into the body, and lower the oxidative stress that certain microplastics cause in cells.
Assessment of the cytotoxicity micro- and nano-plastic on human intestinal Caco-2 cells and the protective effects of catechin.
Researchers used a human intestinal cell line (Caco-2) to test cytotoxicity of polystyrene micro- and nano-plastics, finding dose-dependent cell damage and disruption of intestinal barrier function. The study supports growing concerns that ingested microplastics could contribute to gut inflammation and compromise the protective lining of the human intestine.
Investigating the protective effects of epigallocatechin-gallate against polystyrene microplastics-induced biochemical and hematological alterations in rats
This study investigated whether epigallocatechin-gallate (EGCG) -- a green tea antioxidant -- could protect rats from biochemical and hematological damage caused by polystyrene microplastic ingestion. EGCG supplementation partially mitigated oxidative stress and inflammatory markers elevated by polystyrene microplastic exposure, suggesting a potential dietary protective strategy.
Tea Polyphenol EGCG Increases Nanoplastics Release from Plastic Cups but Mitigates Potential Detrimental Effects
Researchers found that the tea polyphenol EGCG increases nanoplastic release from polystyrene cups during heating, but EGCG simultaneously mitigates the potential detrimental cellular effects of those nanoplastics through its antioxidant properties.
Digestion of Polystyrene Nanoparticles in a Whey Protein Drink. a Simulated in Vitro Gastrointestinal Digestion Using a Batch Infogest Model Combined with Cell Absorption Experiments
This study tracked polystyrene nano- and microplastic particles through a simulated digestive process mixed with a whey protein drink, then tested whether the particles could be absorbed by human intestinal cells. The work contributes to understanding how dietary microplastics survive digestion and whether they can pass through the gut lining into the body.
The effects of polystyrene microplastics on human intestinal cells health and function
This study examined how polystyrene microplastics affect normal and cancer intestinal cells, addressing a gap left by previous research that used only cancer cell lines and pristine plastics. The work evaluated microplastic toxicity under more realistic conditions including digestive system biotransformation, assessing effects on nutrient uptake and cellular function.
Influence of the digestive process on intestinal toxicity of polystyrene microplastics as determined by in vitro Caco-2 models
Researchers studied how the human digestive process transforms polystyrene microplastics and affects their intestinal toxicity using in vitro Caco-2 cell models. The study found that digestion formed a corona on microplastic surfaces without altering their chemical composition, and that smaller particles (100 nm) showed higher toxicity than larger ones (5 micrometers) regardless of digestive treatment.
Biological effects of polystyrene micro- and nano-plastics on human intestinal organoid-derived epithelial tissue models without and with M cells.
Researchers exposed human intestinal organoid-derived epithelial tissue models with and without M cells to polystyrene micro- and nano-plastics, finding that nano-plastics caused greater disruption of barrier integrity and uptake than micro-plastics, and that M cell-containing models showed enhanced particle translocation compared to standard epithelial models.
Uptake and effects of orally ingested polystyrene microplastic particles in vitro and in vivo
Researchers studied the uptake and effects of orally ingested polystyrene microplastic particles using human intestinal cell models and rodent experiments. They found that smaller microplastics were taken up by intestinal cells and could cross the gut barrier, though the majority passed through the digestive system. The study suggests that while most ingested microplastics are excreted, a fraction can be absorbed, warranting further investigation into long-term health effects.
Nanoplastics as a potential environmental health factor: effects of polystyrene nanoparticles on human intestinal epithelial Caco-2 cells
Researchers tested how polystyrene nanoparticles interact with human intestinal cells in the lab. They found that the nanoparticles were readily taken up by the cells in a concentration-dependent manner, but no significant toxic effects were observed under the conditions tested. The study suggests that while nanoplastics can enter gut cells, their short-term toxicity at the tested levels appears limited.
Ingested Polystyrene Micro-Nanoplastics Increase the Absorption of Co-Ingested Arsenic and Boscalid in an In Vitro Triculture Small Intestinal Epithelium Model
Researchers used an advanced intestinal cell model to study whether ingesting polystyrene micro-nanoplastics alongside environmental pollutants like arsenic and boscalid changes how those contaminants are absorbed. They found that the presence of microplastics significantly increased the intestinal uptake of both co-ingested pollutants. The study suggests that microplastics may act as carriers that enhance human exposure to other harmful chemicals through the diet.
Elucidating the Size‐Dependency of In Vitro Digested Polystyrene Microplastics on Human Intestinal Cells Health and Function
Polystyrene microplastics of different sizes were subjected to simulated in vitro digestion and then applied to human intestinal cells, with smaller particles causing greater disruption to cell health and barrier function than larger ones. The results suggest that the smallest microplastics reaching the human gut pose the greatest risk to intestinal integrity.
Autophagic response of intestinal epithelial cells exposed to polystyrene nanoplastics
Researchers found that polystyrene nanoplastics accumulate in the cytoplasm of intestinal epithelial cells, impairing autophagic flux and triggering an autophagic stress response confirmed in both cell and animal models.
Teabag-derived micro/nanoplastics (true-to-life MNPLs) as a surrogate for real-life exposure scenarios
Researchers found that steeping commercial teabags released billions of nanoplastic particles into the tea, made from nylon, polypropylene, or cellulose materials. When human intestinal cells were exposed to these particles, the cells absorbed them -- especially the polypropylene and cellulose types -- raising concerns about everyday plastic ingestion through a common beverage.
Impact of food matrices on the characteristics and cellular toxicities of ingested nanoplastics in a simulated digestive tract
Researchers investigated how different food components affect the toxicity of polystyrene nanoplastics as they pass through a simulated human digestive system. They found that fat molecules helped stabilize and disperse the nanoplastics during digestion, increasing their uptake by intestinal cells and worsening cellular damage. The study suggests that the type of food consumed alongside nanoplastic-contaminated items could significantly influence how much harm the particles cause in the gut.
Mechanisms of ingested polystyrene micro-nanoplastics (MNPs) uptake and translocation in an in vitro tri-culture small intestinal epithelium
Researchers used a sophisticated laboratory model of the human small intestine to study how micro- and nanoplastics cross the gut barrier after simulated digestion. They found that smaller nanoplastics were absorbed more efficiently than larger microplastics, and the particles used multiple cellular pathways to cross the intestinal lining. The study provides new evidence about the mechanisms by which ingested plastic particles could potentially reach the bloodstream.
Impact of a real food matrix and in vitro digestion on properties and acute toxicity of polystyrene microparticles
Researchers examined how interaction with milk as a real food matrix and subsequent digestion affects the properties and toxicity of polystyrene microparticles. The study found that milk proteins form a corona on the particles that alters their surface charge and behavior, suggesting that the food context significantly influences how microplastics behave in the gastrointestinal tract.
Digestion of plastics using in vitro human gastrointestinal tract and their potential to adsorb emerging organic pollutants
Researchers simulated human digestion of polystyrene and polyethylene plastics and found that digestive processes fundamentally altered plastic surfaces, creating new functional groups and generating micro- and nanostructures that can detach. The study suggests that digested plastics have enhanced capacity to adsorb certain pollutants like triclosan and diclofenac, potentially increasing health risks from ingested plastic.
Digestion of microplastics with simulated gastrointestinal conditions mitigates uptake by intestinal epithelial cells: Quantified by imaging flow cytometry
Researchers studied how simulated digestion affects the uptake of microplastics by intestinal cells. They found that microplastics that had been through a simulated digestive process were taken up at significantly lower rates compared to pristine particles. The findings suggest that digestive conditions may reduce how many microplastics actually cross the intestinal barrier, which is important for understanding real-world human exposure.
An inverted in vitro triple culture model of the healthy and inflamed intestine: Adverse effects of polyethylene particles.
Using a laboratory model of the human intestinal lining, researchers tested how polyethylene microplastics affect intestinal cells and found they disrupted the barrier function of the gut wall. A compromised intestinal barrier allows larger molecules and particles to pass into the body, which could amplify the health effects of microplastic ingestion.
Microplastics in our diet: complementary in vitro gut and epithelium models to understand their fate in the human digestive tract.
Researchers used complementary in vitro gut models to study how microplastics behave during human digestion, finding that digestive conditions alter microplastic surface properties and their interactions with gut cells. The work advances understanding of how ingested microplastics may affect the human digestive system.
The Role of the Size and Surface Chemistry of Polystyrene Micro- and Nanobeads in the Interaction with an Advanced In Vitro Tri-Culture Intestinal Barrier Model
Researchers studied how the size and surface chemistry of polystyrene micro- and nanobeads affect their interaction with an advanced three-cell-type intestinal barrier model. The study examined how particle characteristics influence uptake, barrier integrity, and inflammatory responses in the gut lining. The findings suggest that both size and surface modifications play important roles in determining how plastic particles interact with intestinal tissue.
Effects of Digestion, Cell Culture Media, and Mucous on the Physical Properties, Cellular Effects, and Translocation of Polystyrene and Polymethacrylate Nanoparticles
Researchers studied how simulated digestion and mucous barriers affect the physical properties and translocation of polymethacrylate and polystyrene nanoparticles across an in vitro intestinal cell model. The study found that digestion dramatically increased nanoparticle agglomeration and altered surface charge, and that amine-functionalized nanoparticles were able to cross the intestinal barrier regardless of mucous levels, compromising monolayer integrity.
Comparative evaluation of molecular mechanisms triggered by differently functionalized polystyrene nanoplastics in human colon cell lines
Researchers compared the molecular mechanisms triggered by polystyrene nanoplastics with different surface functionalization in human colon cell lines. The study examined how surface chemistry of nanoplastic particles influences their biological interactions with intestinal cells, contributing to understanding of how nanoplastics may affect the human gastrointestinal system.