Papers

61,005 results
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Article Tier 2

Effects of micro(nano)plastics on amphibian cell lines

This study assessed the effects of micro- and nanoplastics on amphibian cell lines as an alternative model system for evaluating plastic toxicity, responding to growing concerns about particle impacts on amphibians and the value of cell-based testing. Plastic particles caused measurable cellular damage in amphibian cells, supporting their use as a screening tool.

2024 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

Ecotoxicological perspectives of microplastic pollution in amphibians

This review summarizes research on how microplastics affect amphibians, which are considered important indicator species for freshwater pollution. Researchers found evidence that microplastics can impair amphibian growth, immune function, and gene expression, with effects varying by species and particle characteristics. The findings raise concerns about the vulnerability of amphibian populations already threatened by habitat loss and other environmental stressors.

2022 Journal of Toxicology and Environmental Health Part B 80 citations
Article Tier 2

Microplastics as an emerging threat to amphibians: Current status and future perspectives

This review summarizes existing research on microplastic contamination in amphibians like frogs and salamanders, finding that over 80% of studied species had accumulated microplastics. The particles persisted in organs, showed toxic and gene-damaging effects, and could transfer through the food chain. Since amphibians are indicators of environmental health, widespread microplastic accumulation in these animals signals broader ecosystem contamination that can ultimately affect human food and water sources.

2024 Heliyon 17 citations
Article Tier 2

How much are microplastics harmful to the health of amphibians? A study with pristine polyethylene microplastics and Physalaemus cuvieri

Researchers exposed frog tadpoles (Physalaemus cuvieri) to polyethylene microplastics and found significant harmful effects including DNA damage, cell toxicity, and abnormal physical development. The microplastics accumulated in multiple tissues including the gills, gut, liver, muscle, and blood. The study provides some of the first evidence that microplastics can affect amphibian health, adding to concerns about their impact on freshwater wildlife.

2019 Journal of Hazardous Materials 239 citations
Article Tier 2

Microplastic pollution and amphibian health: Complex physiological effects of different microplastic types on juvenile Glandirana rugosa

Researchers studied how polypropylene and polyethylene microplastics affect juvenile frogs and found significantly higher mortality rates in microplastic-exposed groups. The frogs showed elevated stress hormones, signs of oxidative damage, and elongated intestines, suggesting their bodies were trying to adapt to the particles. The study highlights that microplastics pose both physical and chemical risks to amphibians, which may contribute to population declines.

2025 Aquatic Toxicology 4 citations
Article Tier 2

Variation in microplastic characteristics among amphibian larvae: a comparative study across different species and the influence of human activity

Scientists examined microplastics inside amphibian larvae from 10 species and found plastic particles in all of them, with blue fibers being the most common type. Larger larvae tended to contain longer plastic fragments, and there was a relationship between human activity levels near habitats and the characteristics of the plastics found. This study shows that microplastic contamination has penetrated freshwater food webs, affecting animals during their most vulnerable developmental stages.

2024 Scientific Reports 15 citations
Systematic Review Tier 1

Micro(nano)plastics as an emerging risk factor to the health of amphibian: A scientometric and systematic review

Only 12 studies have examined microplastic effects on amphibians, concentrated in Brazil and China and limited mostly to the Anura order; lab-tested concentrations were far from environmentally relevant levels, leaving significant knowledge gaps about mechanisms of toxicity in this vertebrate group.

2021 Chemosphere 62 citations
Article Tier 2

Is cell culture a suitable tool for the evaluation of micro- and nanoplastics ecotoxicity?

This review assessed cell culture as a tool for evaluating micro- and nanoplastic ecotoxicity in aquatic organisms, identifying its advantages for high-throughput screening while noting limitations related to relevance to whole-organism and ecosystem-level effects.

2021 Ecotoxicology 33 citations
Article Tier 2

Efectos Celulares De La Exposición a Micropartículas Plásticas En Organismos Acuáticos

This review examines cellular effects of microplastic and nanoplastic exposure in aquatic organisms, synthesizing laboratory evidence that plastics alone or combined with other toxicants cause membrane lysis, mitochondrial damage, reactive oxygen species generation, genotoxicity, and apoptosis.

2022 Kuxulkab
Article Tier 2

Toxicity of silver, lead an nanoplastics to early life stages of amphibians

This study tested the toxicity of silver, lead, and nanoplastics on early life stages of amphibians, which are already declining globally due to human disturbances. Results indicate these contaminants pose additional risks to a group of vertebrates that is highly sensitive to environmental changes due to their permeable skin.

2019 Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Article Tier 2

Microplastics from miscellaneous plastic wastes: Physico-chemical characterization and impact on fish and amphibian development

Researchers created microplastics from real-world miscellaneous plastic waste and tested their effects on zebrafish and frog embryo development. The waste-derived microplastics, which more closely resembled environmental particles than commercial microspheres, caused species-specific effects including delayed hatching in zebrafish and intestinal accumulation and tissue stress in frog embryos.

2021 Ecotoxicology and Environmental Safety 60 citations
Article Tier 2

Life in plastic, it's not fantastic: Sublethal effects of polyethylene microplastics ingestion throughout amphibian metamorphosis

African clawed frogs exposed to polyethylene microplastics throughout metamorphosis showed sublethal effects including reduced body condition and altered development timing, raising concerns that microplastic pollution may threaten amphibian populations already facing global decline.

2023 Figshare
Article Tier 2

Differential effects of microplastic exposure on anuran tadpoles: A still underrated threat to amphibian conservation?

Researchers found that microplastic exposure affects amphibian tadpoles differently depending on the species, with Italian agile frog tadpoles showing reduced survival at high concentrations while green toad tadpoles were more resilient.

2022 Environmental Pollution 33 citations
Article Tier 2

Polystyrene nanoplastics as an ecotoxicological hazard: cellular and transcriptomic evidences on marine and freshwater in vitro teleost models

Researchers tested the effects of two sizes of polystyrene nanoplastics on fish cell lines from both freshwater and marine species. They found that smaller 20-nanometer particles were significantly more toxic than larger 80-nanometer ones, causing cell death through apoptosis and disrupting multiple biological pathways. The study provides evidence that nanoplastic size is a key factor in determining toxicity to aquatic organisms.

2024 The Science of The Total Environment 9 citations
Article Tier 2

Microplastics impair amphibian survival, body condition and function

Tadpoles of the common midwife toad were exposed to polystyrene microspheres at varying concentrations in microcosms, with microplastics reducing feeding, impairing body condition, and showing dose-dependent ingestion of particles. The study provides rare evidence that microplastics harm amphibians, a group already facing global population declines.

2019 Chemosphere 121 citations
Article Tier 2

Microplastics: Their Effects on Amphibians and Reptiles-A Review

This review examines the effects of microplastics on amphibians and reptiles, synthesizing research on ingestion, tissue accumulation, and physiological impacts in these often-overlooked vertebrate groups.

2022 Pakistan Journal of Zoology 26 citations
Article Tier 2

Plastic pollution and its pathophysiological impacts on mammalian cells

This review examines the pathophysiological impacts of microplastics and nanoplastics on mammalian cells, discussing how environmental degradation of larger plastics generates micro- and nano-scale fragments that enter organisms through ingestion, accumulate via trophic transfer, and cause cellular toxicity. The authors synthesize laboratory evidence on MP and NP interactions with mammalian cells including membrane disruption, inflammation, and genotoxicity.

2022 IARJSET
Article Tier 2

Toxicity assessment of pollutants sorbed on microplastics using various bioassays on two fish cell lines

Researchers collected microplastic samples from ocean expeditions and tested their toxicity using two fish cell lines, finding that cell lines differed in sensitivity and that microplastics with sorbed pollutants were toxic to cells. The results suggest that real-world microplastics carrying accumulated chemical pollutants pose a chemical toxicity risk to marine organisms beyond just the physical effects of ingesting plastic.

2016 Infoscience (Ecole Polytechnique Fédérale de Lausanne)
Article Tier 2

Polymethylmethacrylate nanoplastics can cause developmental malformations in early life stages of Xenopus laevis

Researchers demonstrated that polymethylmethacrylate nanoplastics caused developmental malformations in early life stages of Xenopus laevis frogs, identifying PMMA as a previously overlooked nanoplastic pollutant with teratogenic potential for amphibians.

2021 The Science of The Total Environment 38 citations
Article Tier 2

Microplastic prevalence in anatolian water frogs (Pelophylax spp.)

Researchers found microplastics in the tissues of anatolian water frogs (Pelophylax spp.) collected from freshwater habitats in Turkey, documenting prevalence and characteristics of plastic particles in these amphibians whose populations are already stressed by multiple environmental pressures.

2022 Journal of Environmental Management 29 citations
Article Tier 2

Genotoxicity, mutagenicity and immunotoxicity assessment of microplastics and nanoparticle mixture in bullfrog tadpoles

Researchers exposed bullfrog tadpoles to polyethylene microplastics and titanium dioxide nanoparticles, both individually and in combination, for 15 days to assess genetic damage and immune effects. While the pollutants did not cause direct DNA damage at the tested concentrations, the microplastics alone and in combination with nanoparticles triggered changes in immune cell composition. The study suggests that even at relatively low concentrations, microplastics can alter immune function in amphibians, which are among the most threatened vertebrate groups worldwide.

2025 Environmental Research 2 citations
Article Tier 2

Microplastics increase susceptibility of amphibian larvae to the chytrid fungus Batrachochytrium dendrobatidis

Researchers found that microplastic exposure increases the susceptibility of midwife toad larvae to the chytrid fungus Batrachochytrium dendrobatidis, suggesting that plastic pollution may worsen the impacts of this devastating amphibian disease.

2021 Scientific Reports 42 citations
Article Tier 2

Developmental Abnormalities in Tadpoles as Biomarkers to Assess the Ecotoxicity of Traditional and Emerging Pollutants

This review examines how developing tadpoles can serve as sensitive indicators of toxic contamination in aquatic environments, noting that micro- and nanoplastics are among the emerging pollutants shown to cause developmental abnormalities in amphibian larvae. Because amphibians absorb chemicals easily through their permeable skin, they serve as early warning systems for plastic pollution levels that may also threaten other wildlife and ecosystems.

2023
Article Tier 2

Effects of microplastics from cigarette filters on two aquatic species and in vitro human lung cells

Researchers assessed the ecotoxicological effects of microplastics derived from cigarette filters on two aquatic species and conducted in vitro tests for human cellular toxicity. Cigarette filter microplastics caused harm to both aquatic organisms and human cells, confirming them as a toxicologically relevant source.

2024 Zenodo (CERN European Organization for Nuclear Research)