Papers

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Article Tier 2

Probiotics ameliorate polyethylene microplastics-induced liver injury by inhibition of oxidative stress in Nile tilapia (Oreochromis niloticus)

Researchers investigated whether probiotics could protect Nile tilapia from liver damage caused by polystyrene microplastics. The study found that fish pre-fed with probiotics showed significantly reduced oxidative stress markers in the liver compared to those exposed to microplastics alone, suggesting that probiotics may help mitigate microplastic-induced hepatic oxidative damage in fish.

2022 Fish & Shellfish Immunology 56 citations
Article Tier 2

Spirulina platensis supplementation remediates microplastics-induced growth inhibition and stress in Nile tilapia, Oreochromis niloticus

Nile tilapia fish exposed to microplastics showed reduced growth, intestinal damage, and signs of immune stress, but adding the dietary supplement Spirulina to their feed significantly reversed these harmful effects. Spirulina reduced oxidative stress and helped repair gut damage caused by microplastic exposure. While this is a fish study, it suggests that certain natural supplements might help protect against some of the biological damage caused by microplastic ingestion.

2025 Journal of Hazardous Materials Advances 5 citations
Article Tier 2

Multi-Species Probiotics as Sustainable Strategy to Alleviate Polyamide Microplastic-Induced Stress in Nile Tilapia

Researchers tested whether multi-species probiotics could counteract the toxic effects of polyamide microplastics in Nile tilapia over a six-week experiment. The study found that probiotic supplementation alleviated microplastic-induced stress by improving growth performance, immune response, and physiological health markers, suggesting that probiotics may be a sustainable strategy for protecting farmed fish from microplastic contamination.

2025 Sustainability 1 citations
Article Tier 2

Assessment the effect of exposure to microplastics in Nile Tilapia (Oreochromis niloticus) early juvenile: I. blood biomarkers

Researchers exposed juvenile Nile tilapia to different concentrations of microplastics for 15 days followed by a 15-day recovery period and measured blood biomarkers. They found dose-dependent changes in biochemical and hematological parameters, including elevated liver enzymes, altered blood cell counts, and increased glucose levels. Many of these effects persisted even after the recovery period, suggesting that microplastic exposure can cause lasting physiological stress in young freshwater fish.

2019 Chemosphere 258 citations
Article Tier 2

Supplementary Feed Potential on Histology and Immune Response of Tilapia (Oreochromis niloticus L.) Exposed to Microplastics

Researchers found that supplementing tilapia feed with probiotics or vitamin C significantly mitigated microplastic-induced organ damage, reducing liver necrosis and inflammation markers while improving intestinal structure and immune cytokine balance.

2023 Sains Malaysiana 9 citations
Article Tier 2

Effects of Microplastics on Gene Expression, Muscular Performance, and Immunological Responses in Nile Tilapia (Oreochromis niloticus): Seasonal and Habitat Variations

Researchers found microplastics in both the gut and muscle tissue of Nile tilapia fish from two sites along the Nile River in Egypt, with contamination levels varying by season and location. The microplastics activated genes linked to muscle wasting, cell death, and inflammation while suppressing growth-related genes, with the worst effects seen during summer months. Since tilapia is a widely consumed fish, these findings raise concerns about microplastic-related damage being passed to humans through the food supply.

2025 Marine Biotechnology 5 citations
Article Tier 2

Impacts of Nile Tilapia (Oreochromis niloticus) exposed to microplastics in bioflocs system

Researchers assessed the effects of polystyrene microplastics on Nile tilapia raised in a bioflocs aquaculture system over 28 days. While the microplastics did not significantly affect water quality, fish growth, or digestive enzymes, they accumulated most heavily in the liver and increased markers of oxidative stress. The findings suggest that even in biofloc systems rich in beneficial microbes, microplastics can still accumulate in fish organs and cause subtle biological harm.

2023 The Science of The Total Environment 20 citations
Article Tier 2

Impacts of microplastics on reproductive performance of male tilapia (Oreochromis niloticus) pre-fed on Amphora coffeaeformis

Researchers found that microplastics caused significant blood, biochemical, and reproductive harm in male Nile tilapia, including reduced testosterone and testicular damage. However, pre-feeding fish with the diatom Amphora coffeaeformis helped protect against many of these negative effects, suggesting certain dietary supplements may help organisms cope with microplastic exposure.

2021 Environmental Science and Pollution Research 50 citations
Article Tier 2

Evaluation of Toxicological Risks and Effects of Microplastics on Nile Tilapia (Oreochromisniloticus) under in Vitro Laboratory Conditions

This laboratory study evaluated the toxicological effects of microplastics on Nile tilapia (Oreochromis niloticus) under controlled conditions, finding measurable harm at the concentrations tested. The results have implications for managing fish health in aquaculture operations with microplastic-contaminated water.

2023 East African Journal of Biophysical and Computational Sciences 4 citations
Article Tier 2

Integrated transcriptomics and proteomics analyses reveal the ameliorative effect of hepatic damage in tilapia caused by polystyrene microplastics with chlorella addition

Tilapia fish were exposed to polystyrene microplastics of different sizes, and researchers found that the particles caused liver damage including fat metabolism disruption, oxidative stress, and inflammation. Interestingly, adding the green algae Chlorella to the exposure partially helped reduce the harmful effects, suggesting that natural microorganisms may offer some protective benefit against microplastic toxicity in fish.

2024 Ecotoxicology and Environmental Safety 9 citations
Article Tier 2

Growth performance, hematological and oxidative stress responses in Nile tilapia (Oreochromis niloticus) exposed to polypropylene microplastics

Nile tilapia fish fed polypropylene microplastics for 7 weeks showed significantly reduced growth, blood abnormalities indicating anemia, and oxidative stress damage in both liver and brain tissue. The effects were dose-dependent, with higher microplastic concentrations causing more severe harm. Since tilapia is one of the most widely farmed and consumed fish globally, these findings raise concerns about the health of both farmed fish and the people who eat them.

2024 Environmental Quality Management 15 citations
Article Tier 2

Antioxidants and molecular damage in Nile Tilapia (Oreochromis niloticus) after exposure to microplastics

Researchers exposed juvenile Nile Tilapia to different concentrations of microplastics for 15 days followed by a recovery period. The study found dose-dependent increases in oxidative stress markers, DNA fragmentation, and altered protein patterns in fish exposed to microplastics. Evidence indicates that while fish exposed to the lowest concentration recovered after the treatment ended, higher doses caused more persistent damage.

2020 Environmental Science and Pollution Research 192 citations
Clinical Trial Tier 1

The Effect of Exposure to Polystyrene Microplastics in Feed on the Growth of Tilapia (Oreochromis niloticus)

This study exposed tilapia fish to polystyrene microplastics mixed into their feed at different concentrations. The results showed that microplastic exposure negatively affected the growth and development of the fish. This is relevant to human health because tilapia is a widely consumed fish, and microplastics accumulating in farmed fish could be passed along to the people who eat them.

2024 Jurnal Penelitian Pendidikan IPA 2 citations
Article Tier 2

Microplastics induced endocrine disruption, alteration in testicular tissue in tilapia (Oreochromis niloticus) pre-fed on Amphora coffeaeformis

Researchers found that microplastic exposure caused hormonal disruption, reduced sperm quality, and damaged testicular tissue in male tilapia fish, but pre-feeding the fish with a microalgae feed supplement partially protected against these reproductive harms. The study suggests that dietary interventions may help mitigate microplastic toxicity in fish farmed for human consumption.

2021 3 citations
Article Tier 2

Effect of polystyrene microplastics on the antioxidant system and immune response in GIFT (Oreochromis niloticus)

Farmed tilapia exposed to polystyrene microplastics of different sizes showed elevated oxidative stress and immune inflammation markers, particularly in the brain, compared to unexposed fish. The findings suggest chronic microplastic exposure can impair immune defenses in commercially important freshwater fish, raising concerns for both aquaculture and wild fisheries.

2023 Research Square (Research Square) 2 citations
Article Tier 2

Potential of feed supplements on morphometric and gonad weight of fish exposed to microplastics

Researchers investigated whether probiotic supplements from lactic acid bacteria and Vitamin C could mitigate the effects of microplastic exposure on the morphometric measurements and gonad weight of tilapia, finding that feed supplementation supported recovery in fish exposed to microplastic-contaminated diets.

2022 IOP Conference Series Earth and Environmental Science 2 citations
Article Tier 2

Combined Effects of Yellow Mealworm (Tenebrio molitor) and Saccharomyces cerevisiae on the Growth Performance, Feed Utilization Intestinal Health, and Blood Biomarkers of Nile Tilapia (Oreochromis niloticus) Fed Fish Meal-Free Diets

Researchers tested yellow mealworm meal as a replacement for fishmeal in Nile tilapia diets, finding that adding the probiotic yeast Saccharomyces cerevisiae improved fish growth, gut health, liver condition, and immune function. This suggests insect-based feeds combined with probiotics can sustainably replace traditional fishmeal in aquaculture.

2023 Probiotics and Antimicrobial Proteins 13 citations
Article Tier 2

Advances in Understanding Micro‐ and Nanoplastic Toxicity on Farmed Fish and Emerging Nutritional Interventions

This review examined the toxic effects of micro- and nanoplastics on farmed fish and explored emerging nutritional interventions to mitigate those effects. Researchers found that microplastics reduce feed utilization, cause physical abrasion, and trigger oxidative stress in fish, while certain dietary supplements show promise in enhancing fish resilience against microplastic-related toxicity.

2026 Reviews in Aquaculture
Article Tier 2

Impact of sub-chronic polystyrene nanoplastics exposure on hematology, histology, and endoplasmic reticulum stress-related protein expression in Nile tilapia (Oreochromis niloticus)

Researchers exposed Nile tilapia to polystyrene nanoplastics for an extended period and found the particles caused blood cell changes, tissue damage in the liver and gills, and activated stress responses in cellular structures called the endoplasmic reticulum. Even the lowest concentration tested, which matches levels found in the environment, triggered harmful effects. Since tilapia is one of the most consumed farmed fish worldwide, these results highlight potential food safety concerns from nanoplastic contamination in aquaculture.

2024 Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology 13 citations
Article Tier 2

Toxicological assessment of dietary exposure of polyethylene microplastics on growth, nutrient digestibility, carcass and gut histology of Nile Tilapia (Oreochromis niloticus) fingerlings

Researchers fed Nile tilapia fish diets containing different amounts of polyethylene microplastics and found that higher levels significantly reduced growth, nutrient absorption, and body composition. Fish exposed to the highest microplastic concentration (10%) showed severe gut damage visible under a microscope. Since tilapia is widely farmed for human consumption, these findings raise concerns about microplastic contamination affecting both fish health and the safety of farmed seafood.

2024 Ecotoxicology 15 citations
Article Tier 2

Deleterious Effects of Polypropylene Microplastic Ingestion in Nile Tilapia (Oreochromis niloticus)

Researchers fed Nile tilapia daily doses of polypropylene microplastics for 30 days and observed significant health effects including changes in blood cell counts, altered gut bacteria, and tissue damage to the intestines and liver. The higher dose group showed more pronounced effects, including elevated inflammatory markers and signs of oxidative stress. The study provides evidence that chronic ingestion of microplastics commonly found in aquatic environments can cause meaningful harm to a widely consumed fish species.

2023 Bulletin of Environmental Contamination and Toxicology 19 citations
Article Tier 2

Assessing the impact of dietary polystyrene nanoplastics on growth performance, immunological parameters, and antioxidant defense in zebrafish (Danio rerio)

Researchers fed zebrafish diets containing different concentrations of polystyrene nanoplastics for 30 days and observed reduced growth and increased stress markers at higher doses. The study found that nanoplastic exposure triggered oxidative stress, elevated cortisol levels, and altered immune-related gene expression, suggesting potential health impacts on fish from dietary nanoplastic intake.

2024 Journal of the World Aquaculture Society 8 citations
Article Tier 2

Effect of microplastic particles on the gills structure of freshwater fish supplemented with probiotics and vitamin C

This study tested whether commercial feed supplemented with probiotics and vitamin C could repair gill tissue damage in Nile tilapia (Oreochromis niloticus) caused by microplastic particle exposure. Both supplements showed protective effects on gill histology, suggesting dietary interventions may partially mitigate microplastic-induced tissue damage in farmed fish.

2023 IOP Conference Series Earth and Environmental Science 3 citations
Article Tier 2

Chlorella alleviates the intestinal damage of tilapia caused by microplastics

Researchers investigated how polyethylene microplastics of different sizes affect the intestinal health of tilapia and whether Chlorella algae supplementation could alleviate the damage. They found that microplastics caused intestinal histological changes and disrupted enzyme activities, gene expression, and gut microbiota in the fish. The addition of Chlorella showed potential to mitigate some of the intestinal damage caused by nanoscale microplastic exposure.

2024 Chemosphere 12 citations