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61,005 resultsShowing papers similar to Metabolic profile changes of zebrafish larvae in the single- and co-exposures of microplastics and phenanthrene
ClearToxicological effects of microplastics and phenanthrene to zebrafish (Danio rerio)
Researchers exposed zebrafish to polystyrene microplastics, the pollutant phenanthrene, and a combination of both to assess their toxicity over 24 days. They found that co-exposure amplified oxidative stress, suppressed immune gene expression, and significantly disrupted the gut microbiome compared to either contaminant alone. The study suggests that microplastics can worsen the toxic effects of organic pollutants in aquatic organisms by altering how chemicals accumulate and interact in the body.
Effects of microplastics and phenanthrene on gut microbiome and metabolome alterations in the marine medaka Oryzias melastigma
Researchers exposed marine medaka fish to microplastics combined with phenanthrene, a common organic pollutant, and found that the combination disrupted gut bacteria and metabolism more than either substance alone. Specific gut bacterial communities shifted in response to the combined exposure, leading to changes in important metabolic processes. This study underscores that microplastics in the ocean don't act alone; they interact with other pollutants to amplify harm to aquatic organisms and potentially to the humans who consume seafood.
Metabolomic analysis of combined exposure to microplastics and methylmercury in the brackish water flea Diaphanosoma celebensis
Combined exposure of the brackish water flea Diaphanosoma celebensis to microplastics and methylmercury produced metabolomic disruptions greater than either pollutant alone, with the combination altering amino acid metabolism, energy pathways, and oxidative stress markers. The study provides molecular-level evidence that microplastic-mercury co-contamination poses synergistic risks to aquatic invertebrates.
Metabolic Consequences of Developmental Exposure to Polystyrene Nanoplastics, the Flame Retardant BDE-47 and Their Combination in Zebrafish
Researchers examined how developmental exposure to polystyrene nanoplastics and the flame retardant BDE-47, alone and combined, affects zebrafish metabolism, finding that co-exposure produced distinct metabolic disruptions beyond those caused by either contaminant individually.
Complex combined effects of polystyrene nanoplastics and phenanthrene in aquatic models
Researchers investigated the combined toxicity of polystyrene nanoplastics and the pollutant phenanthrene in fish cells and zebrafish larvae. They found that the interaction between nanoplastics and phenanthrene was complex and tissue-dependent, with nanoplastics increasing phenanthrene uptake in some cell types while decreasing it in others. Interestingly, zebrafish larvae experienced lower overall toxicity during co-exposure compared to single-pollutant exposure, suggesting the interaction dynamics are more nuanced than previously assumed.
Combined effects of microplastics and benzo[a]pyrene on Asian sea bass Lates calcarifer growth and expression of functional genes
Researchers exposed juvenile Asian sea bass to polyethylene microplastics and the carcinogen benzo[a]pyrene, both individually and in combination, over 56 days. They found that co-exposure caused more severe effects on growth and gene expression related to immune function and stress response than either contaminant alone. The study highlights that microplastics may worsen the toxic effects of chemical pollutants already present in marine environments.
The Exploration of Joint Toxicity and Associated Mechanisms of Primary Microplastics and Methamphetamine in Zebrafish Larvae
Researchers studied how microplastics and methamphetamine together affect zebrafish larvae, since both pollutants frequently co-occur in waterways. The study found that polystyrene microplastics were more lethal than PVC types, and when combined with methamphetamine at higher concentrations, the toxic effects on survival, behavior, and intestinal health became significantly worse.
Combined hepatotoxicity of imidacloprid and microplastics in adult zebrafish: Endpoints at gene transcription
Researchers investigated the combined liver toxicity of the pesticide imidacloprid and polystyrene microplastics in adult zebrafish over 21 days. The combination caused greater changes in gene expression related to fat and sugar metabolism and inflammatory responses than either contaminant alone. The study suggests that even low concentrations of microplastics and pesticides together may produce more severe hepatotoxic effects than individual exposures.
Integrated analysis of zebrafish gut microbiota and liver transcriptome responses to polystyrene microplastics and cadmium
Researchers exposed zebrafish to polystyrene microplastics and cadmium, both individually and combined, and found that combined exposure caused more severe disruption to gut bacteria and liver gene expression than either pollutant alone. The study revealed that microplastics decreased beneficial gut bacteria while increasing pathogenic species, and the combined treatment suppressed liver xenobiotic metabolism and antioxidant pathways.
Effects of combined exposure to 17α-methyltestosterone and polystyrene microplastics on lipid metabolism and the nervous system in Danio rerio
Researchers exposed zebrafish to a combination of polystyrene microplastics and a synthetic androgen and found significant disruptions to lipid metabolism in the liver and neural function in the brain. The co-exposure caused fatty degeneration of liver cells and altered key signaling pathways involved in nerve communication. The study highlights the compounded risks that arise when aquatic organisms encounter multiple pollutants simultaneously.
Toxicity of parental co-exposure of microplastic and bisphenol compounds on adult zebrafish: Multi-omics investigations on offspring
When adult zebrafish were exposed to combinations of microplastics with bisphenol A (BPA) or bisphenol S (BPS), the reproductive damage was worse than from any single pollutant alone, and the effects carried over to their offspring. The BPA-microplastic combination primarily affected brain function, while BPS-microplastic exposure mainly disrupted visual development in the next generation. This study highlights that microplastics can amplify the harmful effects of common plastic chemicals, with consequences that extend to future generations.
Toxicity evaluation of the combination of emerging pollutants with polyethylene microplastics in zebrafish: Perspective study of genotoxicity, mutagenicity, and redox unbalance
Researchers exposed adult zebrafish to polyethylene microplastics combined with a mixture of common water pollutants for 15 days and assessed DNA damage, mutation rates, and oxidative stress. They found that microplastics alone caused DNA damage and nuclear abnormalities as severe as those caused by the pollutant mixture, challenging the assumption that microplastics are less harmful than chemical contaminants. The study revealed that the fish's antioxidant defenses were overwhelmed across multiple organs, suggesting widespread oxidative damage from microplastic exposure.
Combined effects of microplastics and chemical contaminants on the organ toxicity of zebrafish ( Danio rerio )
Researchers studied the combined effects of microplastics and chemical contaminants like PCBs and methylmercury on zebrafish organs over three weeks of exposure. They found that microplastics carrying adsorbed contaminants produced the most significant effects, particularly on the liver, compared to either microplastics or contaminants alone. The results indicate that microplastics may act as carriers that increase the delivery of harmful chemicals to organisms' tissues.
Effects of microplastics on the toxicity of co-existing pollutants to fish: A meta-analysis
Meta-analysis of 1,380 biological endpoints from 55 studies found that microplastics in co-existing pollutant solutions significantly increased toxicity to fish beyond what the pollutants caused alone, particularly elevating immune system damage, metabolic disruption, and oxidative stress. The effect depended on fish life stage and microplastic size, but not on pollutant or polymer type.
Toxicological mechanisms and molecular impacts of tire particles and antibiotics on zebrafish
Researchers investigated the combined toxic effects of tire microplastics and antibiotics on zebrafish, finding that co-exposure caused more severe damage than either pollutant alone. The combination disrupted liver function, triggered oxidative stress, and altered the expression of genes involved in immune response and metabolism. The study suggests that the widespread co-occurrence of tire particles and antibiotics in waterways may pose compounding risks to aquatic life.
Influence of microplastics on bisphenol A and bisphenol AF toxicity in aquatic environments: Mechanistic insights for environmental risks
Researchers investigated how polyethylene microplastics interact with the industrial chemicals bisphenol A and bisphenol AF in zebrafish, finding that microplastics can either reduce or worsen the toxicity depending on the specific chemical and biological pathway involved. For bisphenol A, the microplastics partially absorbed the chemical and reduced its harmful effects, but for bisphenol AF, they worsened toxicity to certain organ systems. The study reveals that microplastics play a complicated dual role in modifying how other pollutants affect aquatic life.
Co-exposure to polystyrene microplastics and cypermethrin enhanced the effects on hepatic phospholipid metabolism and gut microbes in adult zebrafish
When zebrafish were exposed to both polystyrene microplastics and the pesticide cypermethrin together, the combination caused significantly more liver damage than either pollutant alone. The mixture disrupted fat metabolism in the liver and altered gut bacteria in ways not seen with individual exposures. This matters because microplastics and pesticides frequently co-exist in waterways, and their combined effects on fish health could affect the safety of fish as food.
Methamphetamine Shows Different Joint Toxicity for Different Types of Microplastics on Zebrafish Larvae by Mediating Oxidative Stress
This study examined the joint toxicity of polystyrene and polypropylene microplastics combined with methamphetamine on zebrafish larvae, finding that the drug altered microplastic toxicity in a type-dependent manner via oxidative stress pathways. The results highlight the complexity of combined pollutant exposures in aquatic environments.
Combined effects of polystyrene microplastics and cadmium on oxidative stress, apoptosis, and GH/IGF axis in zebrafish early life stages
Researchers exposed zebrafish embryos to polystyrene microplastics and cadmium, both alone and together, and found that the combination caused significantly worse effects than either pollutant individually. Co-exposure amplified oxidative stress, increased cell death in the spine and esophagus, and disrupted growth hormone pathways more severely than single exposures. The findings suggest that microplastics and heavy metals in waterways may interact to create heightened risks for developing fish.
Additive effects of microplastics on accumulation and toxicity of cadmium in male zebrafish
Researchers exposed adult zebrafish to polyethylene microplastics and cadmium, both individually and in combination, for 21 days. They found that microplastics and cadmium together produced additive toxic effects, increasing cadmium accumulation in fish tissues, altering behavior, and causing more severe organ damage. The study suggests that microplastics in contaminated waterways may worsen the harmful effects of heavy metals on aquatic life.
MPs and PFOS single and combined exposure significantly alter genetic expressions of growth hormone and insulin growth factor-related biomarkers during zebrafish embryonic development
Researchers exposed zebrafish embryos to polyethylene microplastics and the chemical pollutant PFOS, both individually and together, and tracked changes in growth-related gene activity. They found that combined exposure significantly altered the expression of genes controlling growth hormone and insulin-like growth factor pathways more than either pollutant alone. The study suggests that microplastics and PFOS may work together to disrupt normal development in aquatic organisms.
Combined toxicity of polyethylene micro/nanoplastics and PFOA in zebrafish (Danio rerio): Impacts on antioxidant, neurotransmission, and gut microbiota
Researchers exposed zebrafish to polyethylene micro/nanoplastics and the industrial pollutant PFOA individually and in combination, assessing antioxidant capacity, neurotransmission, and gut microbiome composition. Combined exposure caused greater oxidative stress, more severe neurotransmitter disruption, and larger gut microbiome shifts than either contaminant alone, highlighting synergistic risks of co-occurring plastic and PFAS pollution.
Combined exposure with microplastics increases the toxic effects of PFOS and its alternative F-53B in adult zebrafish
Researchers found that when zebrafish were exposed to microplastics along with PFOS or its replacement chemical F-53B (both are "forever chemicals"), the combined toxic effects were worse than either pollutant alone. The microplastics worsened liver inflammation, disrupted energy metabolism, and altered gut bacteria. This is relevant to human health because people are simultaneously exposed to both microplastics and PFAS chemicals through food and water.
Comparative impact of pristine and aged microplastics with triclosan on lipid metabolism in larval zebrafish: Unveiling the regulatory role of miR-217
Scientists found that when microplastics and the antimicrobial chemical triclosan coexist in water, microplastics increase the amount of triclosan that accumulates in zebrafish larvae, disrupting fat metabolism through a specific genetic pathway. Aged microplastics, which have weathered surfaces, actually carried less triclosan and caused less harm than fresh microplastics. This research shows how microplastics can amplify the toxic effects of common household chemicals in aquatic organisms that are part of the food chain.