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Comparative impact of pristine and aged microplastics with triclosan on lipid metabolism in larval zebrafish: Unveiling the regulatory role of miR-217
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Scientists found that when microplastics and the antimicrobial chemical triclosan coexist in water, microplastics increase the amount of triclosan that accumulates in zebrafish larvae, disrupting fat metabolism through a specific genetic pathway. Aged microplastics, which have weathered surfaces, actually carried less triclosan and caused less harm than fresh microplastics. This research shows how microplastics can amplify the toxic effects of common household chemicals in aquatic organisms that are part of the food chain.
The prevalence of microplastics (MPs), especially aged particles, interacting with contaminants like triclosan (TCS), raises concerns about their toxicological effects on aquatic life. This study focused on the impact of aged polyamide (APA) MPs and TCS on zebrafish lipid metabolism. APA MPs, with rougher surfaces and lower hydrophobicity, exhibited reduced TCS adsorption than unaged polyamide (PA) MPs. Co-exposure to PA/APA MPs and TCS resulted in higher TCS accumulation in zebrafish larvae, notably more with PA than APA. Larvae exposed to PA + TCS exhibited greater oxidative stress, disrupted lipid metabolism, and altered insulin pathway genes than those exposed to TCS. However, these negative effects were lessened in the APA + TCS group. Through miRNA-seq and miR-217 microinjection, it was revealed that PA + TCS co-exposure upregulated miR-217, linked to lipid metabolic disorders in zebrafish. Moreover, molecular docking showed stable interactions formed between PA, TCS, and the insulin signaling protein Pik3r2. This study demonstrated that PA and TCS co-exposure significantly inhibited the insulin signaling in zebrafish, triggering lipid metabolism dysregulation mediated by miR-217 upregulation, while APA and TCS co-exposure alleviated these disruptions. This research underscored the ecological and toxicological risks of aged MPs and pollutants in aquatic environments, providing crucial insights into the wider implications of MPs pollution.
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The influence of different polymer types of microplastics on adsorption, accumulation, and toxicity of triclosan in zebrafish
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Researchers investigated how different polymer types of microplastics affect the toxicity and bioaccumulation of the antimicrobial chemical triclosan in zebrafish. They found that polypropylene microplastics had the highest capacity to adsorb triclosan and that co-exposure significantly worsened oxidative stress, lipid damage, and neurotoxicity compared to triclosan alone. The study demonstrates that the type of microplastic polymer matters when assessing the combined environmental risks of plastics and chemical pollutants.
Transgenerational effects of Nanoplastics and bisphenol A on Zebrafish lipid metabolism: Disruption of the gut Microbiota-liver axis via mTOR pathway
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Researchers exposed zebrafish to nanoplastics and bisphenol A, a chemical commonly found in plastics, and tracked the effects across three generations. They found that the combined exposure disrupted fat metabolism, damaged gut bacteria and liver function in the first generation, and these metabolic problems were passed down to offspring that were never directly exposed. The study suggests that nanoplastic and chemical co-exposure may cause health effects that persist across multiple generations.
Metabolic profile changes of zebrafish larvae in the single- and co-exposures of microplastics and phenanthrene
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Researchers exposed zebrafish larvae to microplastics and the pollutant phenanthrene, both individually and together, and analyzed changes in their metabolic profiles. They found that combined exposure triggered unique metabolic disruptions not seen with either contaminant alone, particularly in amino acid metabolism pathways. The study provides evidence that microplastics and organic pollutants can interact to produce novel toxic effects in aquatic organisms.
New insight into intestinal toxicity accelerated by aged microplastics with triclosan: Inflammation regulation by gut microbiota-bile acid axis
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Researchers exposed frogs to aged microplastics carrying triclosan, an antimicrobial chemical commonly found in personal care products, and found the combination was more toxic to the gut than either pollutant alone. The microplastics increased triclosan absorption in the gut by 89%, disrupting gut bacteria and bile acid metabolism, which led to intestinal inflammation. This study shows that microplastics can act as carriers that amplify the harmful effects of other chemicals already present in the environment.
Influence of microplastics on triclosan bioaccumulation and metabolomics variation in Tilapia fish tissues
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Researchers found that polystyrene microplastics significantly altered triclosan bioaccumulation and metabolomic profiles in tilapia tissues, with the gut showing the highest triclosan concentrations and the liver exhibiting the most disrupted metabolic pathways after co-exposure.
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