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61,005 resultsShowing papers similar to Effects of Microplastic on the Gastrointestinal Tract and Gut microbiome of Sprague Dawley Rats
ClearEffects induced by polyethylene microplastics oral exposure on colon mucin release, inflammation, gut microflora composition and metabolism in mice
Researchers fed mice polyethylene microplastics for 30 days and found that even low doses reduced protective mucus in the colon, altered inflammation markers, and shifted the composition of gut bacteria. The microplastics increased the ratio of Bacteroides to Firmicutes bacteria and affected metabolic pathways in the gut microbiome. The study suggests that oral microplastic exposure may disrupt intestinal health by modifying the gut microbial community and its metabolism.
[Effect of microand nanoplastics on the gastrointestinal mucosa and intestinal microbiome].
This review examines how micro- and nanoplastics entering through the food chain affect the gastrointestinal tract, finding evidence of disruption to gut mucosal integrity and intestinal microbiome composition, with implications for digestive health and systemic immune function.
Oral exposure to polyethylene microplastics alters gut morphology, immune response, and microbiota composition in mice
Researchers fed mice polyethylene microplastics of two sizes commonly found in human stool for six weeks and examined the effects on gut health. The study found that microplastic exposure altered gut structure, disrupted immune cell function, changed gene expression related to inflammation and gut barrier integrity, and shifted the composition of gut bacteria. Mice exposed to both sizes simultaneously showed the most severe effects, suggesting that real-world exposure to mixed microplastic sizes may compound the damage.
Polyethylene microplastics affect the distribution of gut microbiota and inflammation development in mice
Researchers fed mice different concentrations of polyethylene microplastics for five weeks and found significant changes in gut bacteria composition and signs of intestinal inflammation. Higher doses increased bacterial diversity and altered the balance of specific bacterial species, while triggering immune responses and inflammation in the colon and duodenum. The study provides evidence that microplastic ingestion can disrupt the gut microbiome and promote intestinal inflammation in mammals.
Impact of microplastics on human gut microbiota: first evidences from in vitro gut models
Researchers investigated the impact of microplastics on human gut microbiota using in vitro gut models, providing early experimental evidence of how microplastic exposure may disrupt intestinal microbial communities. The study offers foundational data on microplastic-microbiome interactions that are difficult to study directly in humans.
Oral exposure to polyethylene microplastics of adult male mice fed a normal or western-style diet: impact on gut and gut-liver axis homeostasis
Researchers orally exposed adult male mice to polyethylene microplastics under both normal and high-fat diets, assessing effects on the gastrointestinal tract. The study found that diet influences microplastic-induced gut changes, with greater effects observed in animals fed a western-style high-fat diet.
Microplastic-induced gut microbiota and serum metabolic disruption in Sprague-Dawley rats
Researchers exposed rats to a mixture of common microplastic types at concentrations reflecting real-world human exposure and found significant disruptions to gut bacteria and blood metabolites. The microplastic mixture altered the balance of beneficial and harmful gut microbes and changed metabolic pathways related to amino acids and lipids. The study suggests that everyday microplastic exposure from food and water may affect mammalian gut health and metabolism.
Toxicological Evaluation of Effects of Some Environmental Pollutants on Intestinal Microbiota: Traditional Review
This review examines how various environmental pollutants affect the gut microbiome — the community of microorganisms in the intestinal tract. Microplastics are among the pollutants discussed, and their ability to alter gut microbiota composition is increasingly recognized as a mechanism by which plastic particles may harm human and animal health.
Exposure to High-molecular-weight Polyvinyl Chloride Alters Bacterial Diversity in the Gut Microbiota of the Wistar Rat
Researchers exposed Wistar rats to high-molecular-weight polyvinyl chloride microplastics through their diet and measured changes in gut microbiota diversity and composition. PVC microplastic ingestion significantly altered bacterial diversity in the gut microbiome, supporting the hypothesis that microplastic exposure can disrupt intestinal microbial ecology with potential consequences for host health.
Gut microbiome remodeling induced by microplastic exposure in humans
This review synthesizes evidence on how microplastic exposure affects the human gut microbiome, drawing on cross-sectional studies of people exposed through plastic food containers and other sources. Evidence indicates that microplastic exposure is associated with shifts in gut bacteria composition, including increases in certain bacterial groups linked to inflammation. The authors explore potential connections between microplastic-induced changes in gut bacteria and the development of various health conditions.
Intestinal flora variation reflects the short-term damage of microplastic to the intestinal tract in mice
Researchers used gut microbiome analysis to track short-term intestinal damage from compositional microplastics (PE, PET, PP, PS, and PVC) in mice over 7 days of exposure. While standard physiological indicators showed no significant changes, histopathological examination and gut flora analysis revealed intestinal tissue damage and microbial community shifts, suggesting that gut microbiota may serve as a sensitive early indicator of microplastic toxicity.
Ingested microplastics pose a potentially serious risk to the gastrointestinal microenvironment
This review argues that ingested microplastics pose a serious potential risk to the gastrointestinal microenvironment by disrupting the gut microbiome, irritating the intestinal lining, and potentially carrying toxic additives and adsorbed chemicals into the digestive tract. Given that human microplastic ingestion is now unavoidable, the authors call for urgent research into gastrointestinal health effects.
Microplastics and health hazards: gastrointestinal risk assessment across a multi-species perspective
This review assesses the gastrointestinal health risks of micro- and nanoplastics across multiple species, from aquatic organisms to mammals, examining how these particles interact with the digestive system. Researchers found that microplastics can cause gut inflammation, alter the microbiome, and potentially cross the intestinal barrier into other tissues. The study highlights that understanding effects across species can help predict potential risks to human digestive health.
A Comprehensive Narrative Review of Potential Gastrointestinal Adverse Effects From Micro(nano) Plastic Exposure
This narrative review synthesizes evidence on gastrointestinal adverse effects of micro- and nanoplastic exposure, examining how these particles interact with gut microbiota, mucosal barriers, and immune tissue to contribute to inflammatory bowel disease, liver disease, and colorectal cancer risk.
Intestinal permeability and gene expression after polyethylene and polyamide microplastic ingestion in Wistar rats
Researchers found that Wistar rats fed polyethylene and polyamide microplastics for five weeks showed changes in intestinal gene expression related to mucin production and immune response, though intestinal permeability was not significantly altered.
Micro(nano)plastics and Their Potential Impact on Human Gut Health: A Narrative Review
This review summarizes research on how micro- and nanoplastics affect the gut, finding that they can damage the intestinal lining, trigger immune responses, and disrupt the balance of beneficial gut bacteria in both cell studies and animal models. Since humans are primarily exposed to microplastics through food and food packaging, understanding these gut effects is essential for assessing the true health risks of plastic pollution.
Gut microbiota as an emerging target for the health implications of microplastics
This review examines how microplastic exposure disrupts the gut microbiome, finding evidence that microplastics damage intestinal barrier proteins, promote inflammation and oxidative stress, and may drive systemic effects including neurotoxicity and reproductive toxicity through gut-mediated pathways.
Intestinal effects of ingested PVC microplastic in Wistar rats
Researchers fed Wistar rats PVC microplastics and assessed intestinal effects including permeability, colonic morphology, and inflammatory markers. The findings showed that ingested PVC microplastics caused measurable changes in gut integrity and inflammation, contributing evidence for gastrointestinal toxicity.
Impact of microplastics on the intestinal microbiota: A systematic review of preclinical evidence
Across 28 preclinical studies, microplastics triggered intestinal dysbiosis characterized by increased Firmicutes and Proteobacteria and decreased Bacteroidetes, while increasing gut permeability and elevating pro-inflammatory cytokines including IL-1β, TNF-α, and IL-6.
Single exposure of food-derived polyethylene and polystyrene microplastics profoundly affects gut microbiome in an in vitro colon model
Using a lab model of the human colon, researchers found that a single exposure to polyethylene and polystyrene microplastics, at levels matching a typical meal, significantly disrupted the gut microbiome. Harmful bacteria overgrew while beneficial bacteria declined, and the balance of bacterial metabolism shifted in unhealthy ways. This suggests that even routine dietary microplastic intake could alter gut health in humans.
Micro(nano)plastics in food system: potential health impacts on human intestinal system.
This review assessed how micro(nano)plastics in the human food system reach the intestine and accumulate in the gut, summarizing evidence that they can alter intestinal barrier function, trigger inflammation, and disrupt the gut microbiome, with implications for long-term digestive health.
Microbial risks associated with microplastics in the food chain and possible control measures (literature review). Part 1. Dietary intake and influence on the gut microbiota
This review summarizes evidence that microplastics commonly found in food and drinking water can disrupt the human gut microbiome when ingested. Studies show that microplastics alter the composition and function of intestinal bacteria, potentially affecting digestion, immunity, and overall health. Since a healthy gut microbiome is essential for human wellbeing, this pathway of harm deserves attention alongside other known risks of microplastic exposure.
Impact of microplastics on the human gut microbiome: a systematic review of microbial composition, diversity, and metabolic disruptions
This systematic review of 12 studies found that microplastics including polyethylene, polystyrene, and PVC induce gut dysbiosis in humans, reducing beneficial bacteria and enriching pathogens. Microplastic exposure also impairs short-chain fatty acid production and modulates immune pathways, contributing to intestinal disease, metabolic syndrome, and chronic inflammation.
Polyethylene terephthalate microplastics affect gut microbiota distribution and intestinal damage in mice
Mice exposed to PET microplastics, the type commonly found in plastic bottles, developed intestinal inflammation, changes in gut bacteria, and signs of a weakened gut barrier. Even at relatively low doses, the microplastics increased liver stress markers and disrupted the protective mucus layer in the colon, suggesting that everyday PET plastic exposure could contribute to digestive health problems.