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Single exposure of food-derived polyethylene and polystyrene microplastics profoundly affects gut microbiome in an in vitro colon model
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Using a lab model of the human colon, researchers found that a single exposure to polyethylene and polystyrene microplastics, at levels matching a typical meal, significantly disrupted the gut microbiome. Harmful bacteria overgrew while beneficial bacteria declined, and the balance of bacterial metabolism shifted in unhealthy ways. This suggests that even routine dietary microplastic intake could alter gut health in humans.
Microplastics (MPs) are widespread contaminants highly persistent in the environment and present in matrices to which humans are extensively exposed, including food and beverages. MP ingestion occurs in adults and children and is becoming an emerging public health issue. The gastrointestinal system is the most exposed to MP contamination, which can alter its physiology starting from changes in the microbiome. This study investigates by an omic approach the impact of a single intake of a mixture of polyethylene (PE) and polystyrene (PS) MPs on the ecology and metabolic activity of the colon microbiota of healthy volunteers, in an in vitro intestinal model. PE and PS MPs were pooled together in a homogeneous mix, digested with the INFOGEST system, and fermented with MICODE (multi-unit in vitro colon model) at loads that by literature correspond to the possible intake of food-derived MPs of a single meal. Results demonstrated that MPs induced an opportunistic bacteria overgrowth (Enterobacteriaceae, Desulfovibrio spp., Clostridium group I and Atopobium - Collinsella group) and a contextual reduction on abundances of all the beneficial taxa analyzed, with the sole exception of Lactobacillales. This microbiota shift was consistent with the changes recorded in the bacterial metabolic activity.
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Impact of polyethylene microplastics on human gut microbiota as assessed in an in vitro gut model
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Scientists used a lab-based model that mimics the human gut to test how tiny plastic particles (microplastics) affect our gut bacteria, the microbes that help digest food and support overall health. The study found that exposure to these plastic particles can change the balance of gut bacteria, which matters because an unhealthy gut microbiome has been linked to issues like digestive problems, weakened immunity, and inflammation. Since microplastics are increasingly found in our food and water, this research adds to growing evidence that we should take their potential health effects seriously.
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