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61,005 resultsShowing papers similar to Lipid Metabolism and Oxidative Stress Altered in Crucian Carp (Carassius auratus) Following Exposure to Microplastics Under Laboratory and Field Conditions
ClearThe effects of exposure to microplastics on grass carp (Ctenopharyngodon idella) at the physiological, biochemical, and transcriptomic levels
Researchers exposed grass carp to microplastics at two concentrations for 21 days and observed liver damage, inhibited growth, and increased oxidative stress. Transcriptome analysis revealed over 1,500 differentially expressed genes related to immune response, metabolism, and cellular stress pathways. The study suggests that microplastic exposure can trigger broad physiological and molecular disruptions in freshwater fish.
Toxic effects of polyethylene microplastics on transcriptional changes, biochemical response, and oxidative stress in common carp (Cyprinus carpio)
Researchers exposed common carp to varying concentrations of polyethylene microplastics and assessed biochemical, oxidative, and gene expression changes. The study found that microplastic exposure caused significant oxidative stress, altered liver enzyme activity, and modified the expression of stress-related genes in a dose-dependent manner.
Transcriptional effects of polyethylene microplastics ingestion in developing zebrafish (Danio rerio)
Researchers exposed developing zebrafish to polyethylene microplastics and used transcriptomic analysis to identify changes in gene expression related to immune function, lipid metabolism, and oxidative stress. The study suggests that even at relatively low concentrations, ingested microplastics can alter key biological pathways during early fish development.
Hepatic multi-level responses to polyethylene microplastics in Lateolabrax maculatus: Insights from transcriptomics, antioxidant enzyme activity, and histopathology
Researchers exposed spotted sea bass to diets containing polyethylene microplastics for 45 days and found multiple levels of liver damage, including altered gene expression, reduced antioxidant enzyme activity, and visible tissue changes. A subsequent depuration period showed partial but incomplete recovery. The study suggests that chronic microplastic exposure through contaminated feed may pose significant risks to liver health in commercially farmed fish species.
Effects of Polystyrene Microplastic Exposure on Liver Cell Damage, Oxidative Stress, and Gene Expression in Juvenile Crucian Carp (Carassius auratus)
Researchers exposed young crucian carp to polystyrene microplastics at different concentrations and found dose-dependent liver damage, with higher concentrations causing more severe tissue injury and weaker antioxidant defenses. The microplastics disrupted genes involved in detoxification and stress response in liver cells. Since crucian carp is a commonly consumed freshwater fish, these findings raise questions about whether microplastic-contaminated fish could affect the health of people who eat them.
Transcriptome sequencing and metabolite analysis reveal the toxic effects of nanoplastics on tilapia after exposure to polystyrene
Researchers exposed larval tilapia to polystyrene nanoplastics and then analyzed changes in gene expression and metabolic profiles after a recovery period. They found that nanoplastic exposure disrupted immune-related pathways, energy metabolism, and lipid processing in the fish, with some effects persisting even after exposure ended. The study suggests that nanoplastics can cause lasting metabolic and immune disruptions in freshwater fish.
Differential effects of foodborne and waterborne micro(nano)plastics exposure on fish liver metabolism and gut microbiota community.
Nile tilapia exposed to equivalent doses of micro(nano)plastics via food versus water showed distinct liver gene expression profiles, indicating that exposure route critically shapes the metabolic and toxicological response. Foodborne MNP exposure produced more pronounced effects on lipid metabolism and inflammation pathways.
Transcriptomic and metabolomic analysis reveals hepatic lipid metabolism disruption in Japanese quail under polystyrene microplastics exposure
Researchers fed Japanese quail polystyrene microplastics at environmentally relevant concentrations for 35 days and analyzed liver effects using transcriptomics and metabolomics. Low doses caused increased food intake and weight gain with liver lipid accumulation, while high doses led to decreased intake and weight loss, suggesting a hormetic dose-response pattern. The study found that microplastic exposure disrupted hepatic lipid metabolism pathways and caused liver oxidative stress in birds.
Polystyrene microplastic exposure disturbs hepatic glycolipid metabolism at the physiological, biochemical, and transcriptomic levels in adult zebrafish
Researchers exposed adult zebrafish to polystyrene microplastics for 21 days and examined effects on liver metabolism at multiple biological levels. The study found that microplastic exposure caused significant decreases in body weight and disrupted glycolipid metabolism, with reduced levels of key metabolic enzymes and gene expression changes in the liver. Transcriptomic analysis confirmed widespread downregulation of genes related to fatty acid, amino acid, and carbon metabolism.
Exposure to microplastics induces lower survival, oxidative stress, disordered microbiota and altered metabolism in the intestines of grass carp (Ctenopharyngodon idella)
Grass carp exposed to environmental concentrations of microplastics (32-40 micrometers, 100 and 1000 micrograms per liter) for 21 days showed reduced survival, elevated oxidative stress markers, disrupted gut microbiota, and altered intestinal metabolism. Microplastics were detected in intestinal tissue at both concentrations, indicating accumulation and systemic effects.
Investigating Polystyrene Nano-Plastic Effects on Largemouth Bass (Micropterus salmoides) Focusing on mRNA Expression: Endoplasmic Reticulum Stress and Lipid Metabolism Dynamics
Researchers investigated how polystyrene nanoplastics affect the liver of largemouth bass, focusing on endoplasmic reticulum stress and fat metabolism. They found that nanoplastic exposure disrupted normal lipid processing and triggered stress responses in liver cells, altering the expression of genes involved in fat storage and energy regulation. The study suggests that nanoplastic pollution in freshwater environments may impair metabolic health in fish.
Transcriptome alterations in zebrafish gill after exposure to different sizes of microplastics
Researchers found that microplastic exposure in zebrafish gills caused size-dependent transcriptomic changes, with smaller particles triggering more differentially expressed genes related to immune response, oxidative stress, and apoptosis pathways compared to larger particles.
Effects of zebrafish exposure to high-density polyethylene and polystyrene microplastics at molecular and histological levels
This study exposed zebrafish to high-density polyethylene and polystyrene microplastics and used genomic analysis to identify which biological pathways were most affected, finding widespread disruption of immune function, metabolism, and stress response genes. The transcriptomic approach reveals that different plastic types activate distinct molecular stress responses in fish.
Effects of polystyrene microplastics acute exposure in the liver of swordtail fish (Xiphophorus helleri) revealed by LC-MS metabolomics
Researchers used metabolomics to investigate the effects of acute polystyrene microplastic exposure on swordtail fish livers. The study found that microplastic exposure caused significant alterations in metabolic pathways related to amino acid metabolism, lipid metabolism, and energy production, indicating broad metabolic disruption even after short-term exposure.
Polystyrene microplastics induce gut microbiome and metabolome changes in Javanese medaka fish (Oryzias javanicus Bleeker, 1854)
Researchers found that polystyrene microplastic exposure altered gut microbiome composition and metabolic profiles in Javanese medaka fish, with effects on amino acid and lipid metabolism pathways suggesting microplastics can disrupt gut health in aquatic organisms.
Lipidomics and transcriptomics insight into impacts of microplastics exposure on hepatic lipid metabolism in mice
Researchers used lipidomics and transcriptomics to examine how polystyrene microplastic exposure affects liver lipid metabolism in mice over eight weeks. The study found that while body weight and serum lipid levels were not significantly affected, microplastics caused impaired glucose metabolism and specific changes in hepatic lipid profiles, revealing subtle but measurable disruptions to liver function.
Assessment of microplastic-contaminated liver through gene expression profiling of four commercial fish species in the Lagos Lagoon, Nigeria
Researchers analyzed the livers of four commercial fish species from the Lagos Lagoon in Nigeria and found microplastic contamination in all of them. Gene expression analysis revealed that the microplastic accumulation triggered changes in genes related to stress response and immune function. The study raises concerns about potential health risks for people who regularly consume fish from polluted urban waterways.
Comprehensive understanding the impacts of dietary exposure to polyethylene microplastics on genetically improved farmed tilapia (Oreochromis niloticus): tracking from growth, microbiota, metabolism to gene expressions
Researchers investigated the impacts of dietary polyethylene microplastics on genetically improved farmed tilapia over nine weeks, tracking effects on growth, gut microbiota, liver metabolism, and gene expression. The study found that microplastic exposure altered gut microbial communities, disrupted liver metabolic processes, and affected gene expression in brain and liver tissues. The findings suggest that microplastic contamination in fish feed and aquatic environments poses risks to farmed fish health.
Effect of Polystyrene Microplastic Exposure on Individual, Tissue, and Gene Expression in Juvenile Crucian Carp (Carassius auratus)
Juvenile crucian carp were exposed to polystyrene microplastics at different concentrations, and researchers found that the particles accumulated mainly in the intestines and gills. The study suggests that microplastic exposure caused tissue damage to multiple organs and altered gene expression, with higher concentrations generally leading to more severe effects.
Molecular Landscape Remodeling Unravels the Cross-Links of Microplastics-Induced Lipidomic Fluctuations, Nutrient Disorders and Energy Disarrangements
Researchers fed mice polypropylene microplastics chronically and used lipidomics and transcriptomics to show that microplastics accumulated in the liver and disrupted lipid metabolism, cholesterol homeostasis, and redox balance, with high doses causing fibrotic liver changes.
Transcriptional response in the whiteleg shrimp (Penaeus vannamei) to short-term microplastic exposure
Researchers exposed whiteleg shrimp (Penaeus vannamei) to microplastics for 96 hours and used transcriptomics to profile gene expression changes, finding significant upregulation of stress response, immune, and detoxification pathways, indicating that even short-term microplastic exposure triggers a broad molecular stress response.
Metabolomic disorders unveil hepatotoxicity of environmental microplastics in wild fish Serranus scriba (Linnaeus 1758)
Researchers analyzed wild painted comber fish from three coastal regions in Tunisia and found small environmental microplastics (3 micrometers and smaller) accumulated in their liver tissue. Using metabolomic analysis, they identified disruptions in liver metabolism linked to microplastic presence, with the severity varying by regional pollution levels. The study provides field-based evidence that environmental microplastics can cause metabolic disorders in the livers of wild fish populations.
Application of transcriptomic profiling to investigate the toxicity mechanisms caused by dietary exposure of nanoplastics in fish
Researchers used transcriptomic profiling to evaluate the impact of dietary nanoplastic exposure on European sea bass, finding changes in gene expression in intestinal tissue after 21 days of feeding with polystyrene nanoparticle-containing food. The study suggests that while no significant changes were observed in enzymatic stress markers, nanoplastics may trigger subtle molecular-level responses in the fish gut.
Molecular LandscapeRemodeling Unravels the Cross-Linksof Microplastics-Induced Lipidomic Fluctuations,Nutrient Disorders and Energy Disarrangements
This study examined how polypropylene microplastics accumulate in and damage the mouse liver, using integrated lipidomics and transcriptomics to map the molecular landscape of microplastic-induced lipid disruption and metabolic dysfunction.