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Metabolomic disorders unveil hepatotoxicity of environmental microplastics in wild fish Serranus scriba (Linnaeus 1758)

The Science of The Total Environment 2022 61 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Omayma Missawi, Iteb Boughattas, Iteb Boughattas, Iteb Boughattas, Iteb Boughattas, Tiziana Cappello, Nesrine Zitouni, Nesrine Zitouni, Nesrine Zitouni, Nesrine Zitouni, Nesrine Zitouni, Nesrine Zitouni, Giuseppe De Marco, Giuseppe De Marco, Giuseppe De Marco, Giuseppe De Marco, Giuseppe De Marco, Omayma Missawi, Omayma Missawi, Omayma Missawi, Omayma Missawi, Omayma Missawi, Noureddine Bousserrhıne, Tiziana Cappello, Tiziana Cappello, Mohamed Bannı Tiziana Cappello, Iteb Boughattas, Iteb Boughattas, Omayma Missawi, Giuseppe De Marco, Giuseppe De Marco, Giuseppe De Marco, Nesrine Zitouni, Nesrine Zitouni, Noureddine Bousserrhıne, Noureddine Bousserrhıne, Noureddine Bousserrhıne, Noureddine Bousserrhıne, Nesrine Zitouni, Nesrine Zitouni, Noureddine Bousserrhıne, Noureddine Bousserrhıne, Noureddine Bousserrhıne, Nesrine Zitouni, Omayma Missawi, Omayma Missawi, Omayma Missawi, Sabrina Belbekhouche, Nesrine Zitouni, Tiziana Cappello, Tiziana Cappello, Nesrine Zitouni, Tiziana Cappello, Tiziana Cappello, Mohamed Bannı Mohamed Bannı Mohamed Bannı Iteb Boughattas, Giuseppe De Marco, Nesrine Zitouni, Omayma Missawi, Tiziana Cappello, Sabrina Belbekhouche, Nesrine Zitouni, Nesrine Zitouni, Omayma Missawi, Tiziana Cappello, Tiziana Cappello, Tiziana Cappello, Mohamed Bannı Tiziana Cappello, Iteb Boughattas, Giuseppe De Marco, Iteb Boughattas, Iteb Boughattas, Nesrine Zitouni, Tiziana Cappello, Hamadi Guerbèj, Nesrine Zitouni, Nesrine Zitouni, Nesrine Zitouni, Vanessa Alphonse, Tiziana Cappello, Tiziana Cappello, Nesrine Zitouni, Iteb Boughattas, Mohamed Bannı Vanessa Alphonse, Iteb Boughattas, Giuseppe De Marco, Giuseppe De Marco, Giuseppe De Marco, Tiziana Cappello, Omayma Missawi, Nesrine Zitouni, Vanessa Alphonse, Omayma Missawi, Vanessa Alphonse, Noureddine Bousserrhıne, Tiziana Cappello, Iteb Boughattas, Iteb Boughattas, Iteb Boughattas, Mohamed Bannı Iteb Boughattas, Mohamed Bannı Tiziana Cappello, Tiziana Cappello, Omayma Missawi, Giuseppe De Marco, Nesrine Zitouni, Noureddine Bousserrhıne, Sabrina Belbekhouche, Nesrine Zitouni, Hamadi Guerbèj, Mohamed Bannı Mohamed Bannı Moncef Mokni, Tiziana Cappello, Moncef Mokni, Omayma Missawi, Mohamed Bannı Vanessa Alphonse, Noureddine Bousserrhıne, Mohamed Bannı Omayma Missawi, Mohamed Bannı Tiziana Cappello, Mohamed Bannı Vanessa Alphonse, Noureddine Bousserrhıne, Sabrina Belbekhouche, Mohamed Bannı Tiziana Cappello, Tiziana Cappello, Mohamed Bannı Sabrina Belbekhouche, Tiziana Cappello, Mohamed Bannı Mohamed Bannı Mohamed Bannı Mohamed Bannı Tiziana Cappello, Moncef Mokni, Vanessa Alphonse, Vanessa Alphonse, Vanessa Alphonse, Noureddine Bousserrhıne, Noureddine Bousserrhıne, Vanessa Alphonse, Sabrina Belbekhouche, Mohamed Bannı Mohamed Bannı Mohamed Bannı Omayma Missawi, Mohamed Bannı Hamadi Guerbèj, Mohamed Bannı Mohamed Bannı Mohamed Bannı Mohamed Bannı Vanessa Alphonse, Vanessa Alphonse, Noureddine Bousserrhıne, Noureddine Bousserrhıne, Mohamed Bannı Tiziana Cappello, Mohamed Bannı Mohamed Bannı Mohamed Bannı Mohamed Bannı Mohamed Bannı Mohamed Bannı Omayma Missawi, Mohamed Bannı Noureddine Bousserrhıne, Noureddine Bousserrhıne, Mohamed Bannı Mohamed Bannı Mohamed Bannı Mohamed Bannı Mohamed Bannı Mohamed Bannı Moncef Mokni, Mohamed Bannı Mohamed Bannı Hamadi Guerbèj, Omayma Missawi, Tiziana Cappello, Mohamed Bannı

Summary

Researchers analyzed wild painted comber fish from three coastal regions in Tunisia and found small environmental microplastics (3 micrometers and smaller) accumulated in their liver tissue. Using metabolomic analysis, they identified disruptions in liver metabolism linked to microplastic presence, with the severity varying by regional pollution levels. The study provides field-based evidence that environmental microplastics can cause metabolic disorders in the livers of wild fish populations.

Polymers

HDPE PE

Body Systems

Hepatic Nervous

Coastal areas are worldwide subject to large inputs of anthropogenic wastes that are discharged directly into inshore waters, where they will be weathered into small microplastics (MPs) of up to a size <20 μm. This study provides information about the presence of small environmental MPs (≤3 μm) in the liver of adult benthopelagic fish Serranus scriba (Linnaeus 1758), caught from three coastal regions in Tunisia distinguished by different patterns of human activity. Polymer composition in fish liver was identified using Raman microspectroscopy. Results revealed differences in the abundance, size distribution and presence of plastic additives over the investigated sites. Polyethylene-vinyl acetate (PEVA: 34% particles/g of tissue), high density polyethylene (HDPE: 24.4%) and the two smaller size classes, i.e. 3-1.2 μm and 1.2-0.45 μm, were the most abundant MPs types and size distribution found, respectively, in Bizerte channel (BC) site (Bizerte city, Tunisia). Moreover, at hepatic level data showed a significant site-dependent cytotoxicity expressed by changes in malondialdehyde (MDA) content, presence of reactive oxygen species (ROS) expressed by altered level of catalase (CAT) and glutathione-S-transferase (GST) activities and in the content of metallothioneins (MTs), as well as genotoxicity by changes in the amount of micronucleus (MN), and neurotoxicity by altered activity of acetylcholinesterase (AChE). A innovative metabolomics analysis was also performed to further investigate the distinct patterns of key metabolite changes in the liver of Serranus scriba. A total of 36 metabolites were significantly affected, mainly involved in energy, amino acid and osmolyte metabolism. These findings emphasised for the first time a close relationship between the source, abundance and size ranges of environmental MPs ≤ 3 μm and their hepatotoxicity in wild organisms.

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