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61,005 resultsShowing papers similar to Gender-specific effects of prenatal polystyrene nanoparticle exposure on offspring lung development
ClearMaternal exposure to polystyrene nanoplastics induces sex-specific kidney injury in offspring
Researchers found that when pregnant mice were exposed to polystyrene nanoplastics (nano-sized plastic particles), their male offspring suffered more severe kidney damage than females — including reduced kidney cell numbers, increased scarring, and altered immune responses. The sex-specific nature of these effects suggests that nanoplastic exposure during pregnancy may carry different long-term health risks depending on the sex of the child.
Maternal exposure to polystyrene nanoplastics induces sex-specific cardiotoxicity in offspring mice
When pregnant mice were exposed to polystyrene nanoplastics, their offspring developed heart damage that differed between males and females. Female offspring lost more body and heart weight, while males showed signs of atherosclerosis and females showed viral heart inflammation markers. This study suggests that prenatal nanoplastic exposure could program sex-specific cardiovascular problems in children, raising concerns about plastic exposure during pregnancy.
Effects of polystyrene nanoplastic gestational exposure on mice
Researchers exposed pregnant mice to airborne polystyrene nanoplastics and studied the effects on both mothers and offspring. High-dose exposure caused fatty liver disease in the mothers and in adult female offspring, but not in male offspring, with each group showing different underlying molecular mechanisms. The study suggests that prenatal exposure to airborne nanoplastics may have sex-specific effects on metabolic health that persist into adulthood.
Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy
Researchers found that nanoscale polystyrene particles inhaled by pregnant mice were able to cross into the placenta and deposit in fetal tissues. The findings raise concerns about potential developmental risks from airborne nanoplastic exposure during pregnancy.
Sex differences in cardiac fibrosis induced by gestational exposure to polystyrene nanoplastics in mice offspring
Researchers exposed pregnant mice to polystyrene nanoplastics and examined the hearts of their adult offspring, finding dose-dependent cardiac fibrosis and cell death that differed between males and females. Male offspring showed greater changes in estrogen receptor gene expression compared to females, which may explain the observed sex differences in heart damage. The study suggests that prenatal nanoplastic exposure could have lasting effects on heart health, with males potentially more vulnerable.
Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy
Researchers exposed pregnant mice to nanoscale polystyrene particles through inhalation and tracked where the particles traveled. They found that the nanoplastics crossed from the lungs into the bloodstream and accumulated in both placental and fetal tissues, confirming that inhaled plastic nanoparticles can reach developing offspring during pregnancy.
Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny
When pregnant mice were exposed to polystyrene nanoplastics, their offspring showed abnormal brain development including changes in neural stem cell function, altered brain structure, and cognitive problems. The effects were gender-specific, with some deficits appearing more strongly in one sex. This study raises concerns that nanoplastic exposure during pregnancy could increase the risk of neurodevelopmental problems in children.
Maternal polystyrene nanoplastics exposure during pregnancy induces obesity development in adult offspring through disrupting lipid homeostasis
Researchers found that maternal inhalation exposure to polystyrene nanoplastics during pregnancy induced obesity development in adult offspring of mice, suggesting in utero exposure to airborne nanoplastics programs metabolic dysfunction. The study linked prenatal nanoplastic exposure to increased adiposity and metabolic changes persisting into adulthood.
Nanopolystyrene Translocation and Fetal Deposition After Acute Lung Exposure During Late-Stage Pregnancy
Nanopolystyrene particles inhaled by pregnant mice during late pregnancy crossed into the bloodstream and deposited in fetal tissues. This finding raises concern that airborne nanoplastics could pose a risk to fetal development, especially given growing human exposure to plastic particles in indoor and outdoor air.
Ferroptosis Is Involved in Sex-Specific Small Intestinal Toxicity in the Offspring of Adult Mice Exposed to Polystyrene Nanoplastics during Pregnancy
When pregnant mice were exposed to 80-nanometer polystyrene nanoplastics through inhalation, their offspring developed intestinal damage involving oxidative stress and a type of cell death called ferroptosis. Female offspring were more severely affected than males, showing sex-specific vulnerability to prenatal nanoplastic exposure. This study raises concerns that breathing in nanoplastics during pregnancy could harm the developing gut of unborn children, with potentially different effects on boys and girls.
Maternal exposure to polystyrene nanoplastics impacts developmental milestones and brain structure in mouse offspring
Researchers exposed pregnant mice to polystyrene nanoplastics and studied the effects on their offspring's brain development. The study found that maternal nanoplastic exposure affected developmental milestones and brain structure in the young mice. The findings suggest that nanoplastic exposure during pregnancy may pose risks to fetal brain development, though more research is needed to understand the implications for humans.
Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy
This animal study found that nanopolystyrene particles inhaled by pregnant mice during late pregnancy were transferred across the placenta and deposited in fetal tissues. The findings provide experimental evidence that airborne nanoplastics can reach unborn fetuses, raising serious concerns about developmental exposure from breathing indoor or outdoor air containing plastic particles.
Single pulmonary nanopolystyrene exposure in late-stage pregnancy dysregulates maternal and fetal cardiovascular function
A single lung exposure to nanoplastics in pregnant rats during late pregnancy reduced fetal and placental weight and caused cardiovascular problems in both the mother and the developing fetus. The nanoplastics disrupted blood flow through the uterine arteries and impaired fetal heart function. This study is concerning because it shows that even a brief inhalation of nanoplastics during pregnancy can have immediate effects on fetal development.
Gestational exposure to micro and nanoplastics differentially impacts cardiac development and function in male and female rats throughout the lifespan
Researchers exposed pregnant rats to airborne micro- and nanoplastics and tracked heart development and function in their offspring from before birth through three months of age. They found that the exposure caused sex-specific cardiac changes, including altered heart wall thickness and chamber dimensions that persisted into adulthood. The study suggests that prenatal microplastic exposure may program lasting cardiovascular differences, with male and female offspring affected in distinct ways.
Maternal exposure to polystyrene nanoplastics leads to ovotoxicity in female mouse offspring
Researchers exposed pregnant mice to polystyrene nanoplastics throughout mating, pregnancy, and nursing, then examined the ovaries of their female offspring. They found that maternal nanoplastic exposure significantly reduced ovarian weight and follicle numbers in the offspring and lowered the expression of key antioxidant genes. The study suggests that nanoplastic exposure during pregnancy may pose risks to the reproductive development of female offspring.
Microplastics and nanoplastics, emerging pollutants, increased the risk of pulmonary fibrosis in vivo and in vitro: A comparative evaluation of their potential toxicity effects with different polymers and size
Researchers compared the lung toxicity of microplastics and nanoplastics made from polystyrene, polyethylene, and polypropylene in mice and human lung cells. They found that all particle types induced signs of pulmonary fibrosis, inflammation, and tissue remodeling, with polystyrene nanoplastics causing the most severe effects. The study suggests that smaller nanoplastic particles and certain polymer types may pose greater risks to lung health.
Unveiling the Pulmonary Toxicity of Polystyrene Nanoplastics: A Hierarchical Oxidative Stress Mechanism Driving Acute–Subacute Lung Injury
Researchers investigated the pulmonary toxicity of polystyrene nanoplastics smaller than 100 nm in lung epithelial cells and macrophages, finding that exposure triggered a hierarchical oxidative stress mechanism that drove acute to subacute lung injury through lipid peroxidation and inflammation.
Teratological, neurochemical and histomorphic changes in the limbic areas of F1 mice progeny due to co-parental polystyrene nanoplastic exposure
Researchers exposed parent mice to polystyrene nanoplastics before and during pregnancy and found that offspring exhibited skeletal and visceral malformations, impaired neonatal reflexes, learning deficits, and structural brain changes — including reduced hippocampal neurons — demonstrating transgenerational neurodevelopmental harm from nanoplastic exposure.
Sex-specific gene expression alterations in response to ingested PVC microplastics in Wistar rats
Researchers examined sex-specific differences in gene expression changes in mice exposed to PVC microplastics via ingestion, finding that male and female animals responded differently at the molecular level. The sex-specific patterns suggest that biological sex may be an important variable in microplastic health risk assessments.
Size-Dependent PulmonaryToxicity and Whole-Body Distributionof Inhaled Micro/Nanoplastic Particles in Male Mice from Chronic Exposure
Researchers used a whole-body inhalation exposure system to chronically expose male mice to polystyrene micro- and nanoplastics at environmental concentrations and tracked particle distribution and lung toxicity. Nanoplastics (80 nm) showed greater tissue transport than microplastics (1 µm), with highest accumulation in lungs followed by blood and spleen, and both sizes disrupted oxidative balance and antioxidant defenses.
Exposure to polystyrene nanoplastics impairs sperm metabolism and pre-implantation embryo development in mice
This study found that male mice given polystyrene nanoplastics by mouth showed significant harm to sperm function and early embryo development, with changes in gene expression that could affect offspring. The findings raise concerns that nanoplastic exposure could impair male fertility and potentially pass harmful effects to the next generation.
Characterisation of changes in global genes expression in the lung of ICR mice in response to the inflammation and fibrosis induced by polystyrene nanoplastics inhalation
Researchers exposed mice to inhaled polystyrene nanoplastics for two weeks and used microarray analysis to identify 115 differentially expressed lung genes, with inflammation and fibrosis pathways significantly upregulated — findings that propose specific gene biomarkers for monitoring nanoplastic-induced pulmonary damage.
Repeated inhalation exposure to polystyrene nanoplastics induced sustained pulmonary injury and fibrosis in mice.
Scientists exposed mice to tiny plastic particles found in air pollution and discovered these particles caused serious lung damage and scarring that didn't heal even weeks after exposure stopped. The smallest plastic particles were the most harmful, spreading from the lungs to other organs like the heart and liver. This research suggests that breathing in nanoplastics from everyday sources like car tire wear and plastic waste could pose long-term risks to human lung health.
Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny
Researchers found that maternal exposure to polystyrene nanoplastics caused brain abnormalities in offspring, demonstrating that nanoplastics can cross maternal barriers and affect neurological development in progeny with implications for developmental toxicology.