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Sex-specific gene expression alterations in response to ingested PVC microplastics in Wistar rats
Summary
Researchers examined sex-specific differences in gene expression changes in mice exposed to PVC microplastics via ingestion, finding that male and female animals responded differently at the molecular level. The sex-specific patterns suggest that biological sex may be an important variable in microplastic health risk assessments.
Exposure to microplastics to humans is of growing concern, as humans are exposed to microplastic particles daily through ingestion and inhalation. Ingestion of contaminated food and beverages, as well as the leaching of microplastics from food contact materials, is believed to be the primary route of human exposure. This study aims to investigate the effects of ingested polyvinyl chloride (PVC) microplastic on overall's wellbeing and gene expression in several organs in Wistar rats. Methods: The animals were exposed to self-made irregular PVC particles with a continuous size distribution ( Also see: https://micro2024.sciencesconf.org/559171/document
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