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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Environmental Sources Food & Water Human Health Effects Sign in to save

Sex-specific gene expression alterations in response to ingested PVC microplastics in Wistar rats

Zenodo (CERN European Organization for Nuclear Research) 2024
Jutta Dierkes, Alice Refosco, Lucie Geelhaar, Damaris Benny Daniel, Nazar Gafar Abdulrahman Mohamed, Hans-Peter Marti

Summary

Researchers examined sex-specific differences in gene expression changes in mice exposed to PVC microplastics via ingestion, finding that male and female animals responded differently at the molecular level. The sex-specific patterns suggest that biological sex may be an important variable in microplastic health risk assessments.

Polymers
PVC
Body Systems
Respiratory
Models
Human Rat

Exposure to microplastics to humans is of growing concern, as humans are exposed to microplastic particles daily through ingestion and inhalation. Ingestion of contaminated food and beverages, as well as the leaching of microplastics from food contact materials, is believed to be the primary route of human exposure. This study aims to investigate the effects of ingested polyvinyl chloride (PVC) microplastic on overall's wellbeing and gene expression in several organs in Wistar rats. Methods: The animals were exposed to self-made irregular PVC particles with a continuous size distribution ( Also see: https://micro2024.sciencesconf.org/559171/document

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