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61,005 resultsShowing papers similar to Oral Exposure to Nylon-11 and Polystyrene Nanoplastics During Early-Life in Rats
ClearNeurobehavioral assessment of rats exposed to pristine polystyrene nanoplastics upon oral exposure
Researchers orally dosed male rats with polystyrene nanoparticles at four doses for five weeks and found no statistically significant neurobehavioral effects across a battery of tests, though subtle trends such as increased open-arm exploration in the elevated plus maze suggest that even pristine nanoplastics may produce low-level behavioral signals warranting further investigation.
[Effects of nanopolystyrene nanoplastic exposure on the development and neurotoxicity of fetal rats during gestation].
Researchers found that gestational exposure to polystyrene nanoplastics in rats caused dose-dependent reductions in fetal body weight, body length, and brain development, with smaller 25 nm particles producing more pronounced neurotoxic effects than 50 nm particles.
Effects of orally administered polystyrene nanoplastics on reproduction and development in rodents
This study examined the reproductive and developmental effects of orally administered polystyrene nanoplastics in an animal model, finding that NP ingestion impaired fertility metrics and offspring development, contributing to growing evidence of nanoplastic reproductive toxicity.
Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny
Researchers found that maternal exposure to polystyrene nanoplastics caused brain abnormalities in offspring, demonstrating that nanoplastics can cross maternal barriers and affect neurological development in progeny with implications for developmental toxicology.
Evidence on Invasion of Blood, Adipose Tissues, Nervous System and Reproductive System of Mice After a Single Oral Exposure: Nanoplastics versus Microplastics.
Researchers found that after a single oral exposure in mice, nanoplastics were rapidly absorbed into the blood, accumulated in fat tissues, and crossed both the blood-brain and blood-testis barriers. The study demonstrated that the distribution and behavior of plastic particles in mammals is strongly dependent on particle size, with nanoplastics showing substantially greater tissue penetration than microplastics.
Uptake Routes and Biodistribution of Polystyrene Nanoplastics on Zebrafish Larvae and Toxic Effects on Development
Researchers exposed zebrafish embryos and larvae to amino-modified polystyrene nanoplastics to study uptake routes and biodistribution. The study found that nanoplastics accumulated in target organs and caused toxic developmental effects, providing evidence that these tiny plastic fragments can penetrate biological barriers and interfere with normal development in aquatic organisms.
Fabrication of Nylon-6 and Nylon-11 Nanoplastics and Evaluation in Mammalian Cells
Researchers fabricated well-characterized nylon-6 and nylon-11 nanoplastics and evaluated their effects on mammalian cells, addressing a critical gap since most toxicity studies rely on polystyrene beads that do not represent the diversity of plastics found in the environment.
Orally administered fluorescent nanosized polystyrene particles affect cell viability, hormonal and inflammatory profile, and behavior in treated mice
Researchers found that orally administered fluorescent polystyrene nanoparticles passed through the mouse digestive system and accumulated in multiple organs. The study observed changes in cell viability, hormonal and inflammatory profiles, and behavior in treated mice, providing evidence that ingested nanoplastics can cross biological barriers and affect multiple body systems.
Micro- and nanoplastics: origin, sources of intake and impact on human health (literature review)
This literature review synthesizes mechanisms by which micro- and nanoplastics interact with living organisms, examining their physicochemical properties, routes of human exposure, and documented health effects across multiple organ systems.
Dose‐Dependent Toxicological Effects of Polyvinyl Chloride and Polystyrene Microplastics on Wistar Albino Rats
Researchers fed rats PVC and polystyrene microplastics at different doses for eight weeks and observed significant changes including weight loss, elevated blood glucose, increased cholesterol and liver enzymes, and signs of oxidative stress. The study suggests that oral microplastic exposure at these levels can cause dose-dependent toxicological effects across multiple organ systems in mammals.
Ingested Polystyrene Nanospheres Translocate to Placenta and Fetal Tissues in Pregnant Rats: Potential Health Implications
In a study on pregnant rats, researchers found that ingested nanoplastics (tiny 25-nanometer plastic spheres) crossed both the intestinal barrier and the placental barrier to reach every fetal organ examined, including the brain, heart, liver, kidneys, and lungs. This is the first study to directly demonstrate that swallowed nanoplastics can travel from a mother's gut to developing fetal tissues. The findings raise serious concerns about potential health effects of nanoplastic exposure during human pregnancy.
Nanoplastic toxicology following gestational and lactational exposure
This review examines evidence from animal studies showing that polystyrene nanoplastics can cross the placental barrier during pregnancy, accumulate in maternal and offspring organs, and cause widespread toxicity. Reported effects in offspring include reproductive and endocrine disruption, neurodevelopmental abnormalities, cardiovascular damage, and metabolic disorders, with the severity of effects influenced by particle size, dose, and timing of exposure.
Biological interactions between nanomaterials and placental development and function following oral exposure
Researchers reviewed animal studies on orally ingested nanomaterials (including nanoplastics) and found that while the placenta is generally an effective barrier preventing fetal transfer, nanomaterials accumulating in placental tissue can impair placental development and function, with potential downstream effects on fetal health.
The Uptake and Distribution Evidence of Nano- and Microplastics in vivo after a Single High Dose of Oral Exposure.
This in vivo study provided evidence on the uptake and organ distribution of nano- and microplastics following a single high-dose administration, finding that nanoplastics translocated rapidly to multiple organs through blood circulation while only small amounts of larger microplastics penetrated organs.
Microplastics: A threat for developing and repairing organs?
This review examines how micro- and nanoplastics may affect organ development and repair in humans and animals. Researchers found evidence that these particles and their chemical additives can disrupt critical developmental processes in multiple organs, including during fetal development via placental exposure. The study suggests that micro- and nanoplastics pose particular risks during early developmental windows and when the body is attempting to regenerate damaged tissue.
In vivo impact assessment of orally administered polystyrene nanoplastics: biodistribution, toxicity, and inflammatory response in mice
Researchers orally administered polystyrene nanoplastics to mice for two weeks and tracked their distribution and biological effects. The nanoplastics accumulated primarily in the intestine, kidneys, and liver, triggering significant inflammatory responses and oxidative stress in these organs despite no visible tissue damage. The study provides evidence that even short-term oral exposure to nanoplastics can cause meaningful inflammatory changes in multiple organ systems.
Effects of nanoplastic exposure during pregnancy and lactation on neurodevelopment of rat offspring
When pregnant and nursing rats were exposed to polystyrene nanoplastics, their offspring showed thinner brain cortexes, disrupted neurotransmitter levels, damaged connections between brain cells, and problems with anxiety and spatial memory. This study suggests that maternal exposure to nanoplastics during pregnancy and breastfeeding could affect brain development in offspring.
To what extent are orally ingested nanoplastics toxic to the hippocampus in young adult rats?
Researchers investigated polystyrene nanoplastic toxicity to the hippocampus in young adult rats, finding that oral exposure caused oxidative stress, inflammation, and histopathological changes in brain tissue with potential implications for cognitive function.
Micro and nano-plastics, a threat to human health?
This review examines the threat micro- and nanoplastics pose to human health, discussing how these persistent particles accumulate in organs including lungs, the gastrointestinal system, and blood, and how their chemical composition and size influence toxicity.
Oral toxicity of small microplastic of polyamide assessed by a standardized guideline study
Researchers conducted a standardized 28-day oral toxicity study feeding rats high doses (1,000 mg per kilogram of body weight per day) of tiny polyamide (nylon) microplastics, finding no detectable toxic effects on blood, organs, or tissue in any of the animals. While reassuring at this dose level, the authors note the study used pristine particles and that real-world exposure involves weathered plastics with potentially different properties.
Effects of Nanoplastics on Human Health: A Comprehensive Study
This comprehensive review examines the diverse health effects of nanoplastics, drawing on toxicology, environmental science, and epidemiology to document how these particles interact with human biological systems. The authors conclude that nanoplastics represent a growing public health concern requiring further investigation.
Cellular and Systemic Effects of Micro- and Nanoplastics in Mammals—What We Know So Far
This review summarized known cellular and systemic effects of micro- and nanoplastics in mammals, finding that while ingestion is common, knowledge of health impacts remains limited, with oxidative stress and inflammation as the most reported biological responses.
Micro- and nanoplastic toxicity: A review on size, type, source, and test-organism implications
This comprehensive review analyzed 615 studies on the toxicity of micro- and nanoplastics across different polymer types, sizes, and organisms. A major finding is that over 90% of nanoplastic research uses only polystyrene, leaving huge gaps in our understanding of other common plastics at the nanoscale. The review highlights that smaller particles are generally more toxic and that more research is urgently needed on the nanoplastics people are most likely to encounter in everyday life.
Excretion characteristics of nylon microplastics and absorption risk of nanoplastics in rats
Researchers examined the excretion dynamics of nylon microplastics in rats, finding that fibrous particles were retained longer than granular ones, while nanoplastics could cross the intestinal barrier and accumulate in organs including the liver and kidneys.