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Fabrication of Nylon-6 and Nylon-11 Nanoplastics and Evaluation in Mammalian Cells
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Researchers fabricated well-characterized nylon-6 and nylon-11 nanoplastics and evaluated their effects on mammalian cells, addressing a critical gap since most toxicity studies rely on polystyrene beads that do not represent the diversity of plastics found in the environment.
Microplastics (MPs) and nanoplastics (NPs) exist in certain environments, beverages, and food products. However, the ultimate risk and consequences of MPs and NPs on human health remain largely unknown. Studies involving the biological effects of small-scale plastics have predominantly used commercially available polystyrene beads, which cannot represent the breadth of globally dominant plastics. Nylon is a commodity plastic that is used across various industry sectors with substantial global production. Here, a series of well-characterized nylon-11 and nylon-6 NPs were successfully fabricated with size distributions of approximately 100 nm and 500 nm, respectively. The facile fabrication steps enabled the incorporation of fluorescent tracers in these NPs to aid the intracellular tracking of particles. RAW 264.7 macrophages were exposed to nylon NPs in a dose-dependent manner and cytotoxic concentrations and cellular uptake were determined. These well-characterized nylon NPs support future steps to assess how the composition and physicochemical properties may affect complex biological systems and ultimately human health.
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Fabrication of microplastic and nanoplastic particles and fibres for use in pulmonary toxicity studies
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Researchers developed fabrication methods to produce micro- and nanoplastics from three environmentally relevant polymers (polyamide, polypropylene, and PET) in both particle and fiber shapes, addressing a critical gap in pulmonary toxicity research where most studies use only polystyrene spheres.
Fabrication of microplastic and nanoplastic particles and fibres for use in pulmonary toxicity studies
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Researchers developed fabrication methods for polyamide, polystyrene, and polyethylene terephthalate micro/nanoplastics in both particle and fiber forms, producing respirable-sized test materials with verified chemical purity for use in more environmentally realistic lung toxicity studies.
Fabrication of microplastic and nanoplastic particles and fibres for use in pulmonary toxicity studies
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Researchers developed methods to fabricate polyamide, polystyrene, and polyethylene terephthalate micro/nanoplastics in particle and fiber forms of respirable dimensions, addressing the limitation that most pulmonary toxicity studies have used only commercially available polystyrene spheres.
Cellular and Animal Toxicities of Micro- and Nanoplastics
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Researchers reviewed evidence from cell and animal studies on the toxic effects of micro- and nanoplastics, finding that these particles can cause inflammation, oxidative stress, and organ damage in laboratory models, raising concern about what chronic low-level human exposure might mean for long-term health.
In Vitro High-Throughput Toxicological Assessment of Nanoplastics
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This study performed high-throughput toxicological screening of nanoplastics produced by laser ablation and colloidal synthesis, characterizing their physicochemical properties alongside biological activity. The in vitro assay approach enables rapid assessment of nanoplastic toxicity across a range of particle types and concentrations.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.