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61,005 resultsShowing papers similar to Metabolomics Approach in Environmental Studies: Methodologies, Application and Challenges
ClearMicroplastics to Metabolomics: Understanding the environmental and health implications of plastic pollution
This review explores how metabolomics, a technique for analyzing small molecules in biological systems, is being used to understand how microplastic exposure affects living organisms at the biochemical level. The authors examine both targeted and untargeted metabolomics approaches that can reveal changes in metabolic pathways caused by microplastic pollution. The study suggests that metabolomics could become a powerful tool for identifying early biomarkers of microplastic-related health effects.
Study on toxicity effects of environmental pollutants based on metabolomics: A review
This review examines how metabolomics, a technology that measures changes in small molecules within organisms, is being used to study the toxic effects of environmental pollutants including microplastics, heavy metals, and pesticides. Researchers found that metabolomics can reveal subtle biological changes caused by pollutant exposure that traditional methods might miss. The study highlights metabolomics as a powerful tool for understanding how environmental contaminants disrupt normal biological processes at the molecular level.
A metabolomics perspective on the effect of environmental micro and nanoplastics on living organisms: A review
This review examines how scientists use metabolomics, the study of small molecules produced by cellular processes, to understand the toxic effects of microplastics and nanoplastics on living organisms. The research shows that these plastic particles disrupt metabolism in consistent ways across species, affecting energy production, fat processing, and amino acid pathways. These shared metabolic disruptions across different organisms suggest that microplastics could cause similar metabolic problems in humans.
Metabolomic Studies for the Evaluation of Toxicity Induced by Environmental Toxicants on Model Organisms
This review described how environmental metabolomics — measuring small-molecule profiles in model organisms — can be used to assess the toxicity of environmental contaminants including microplastics, heavy metals, and pesticides, and highlighted key organisms, methods, and data analysis approaches.
Metabolomics-Based Insights Into the Toxicological Effects and Mechanisms of Microplastics: A Comprehensive Review.
This review of existing research shows that microplastics—tiny plastic particles found everywhere in our environment—can harm multiple body systems including the gut, brain, and reproductive organs. Scientists used a technique called metabolomics (studying how our body processes chemicals) to discover that microplastics disrupt normal metabolism, potentially affecting everything from digestion and brain function to fertility and child development. This research helps explain why microplastic pollution may be a serious health threat that requires urgent attention and solutions.
Multi-Omics Approach on the Ecotoxicological Assessment of Microplastics
This review examines the application of multi-omics approaches — including genomics, transcriptomics, proteomics, and metabolomics — to the ecotoxicological assessment of microplastics in living organisms. The authors synthesize how these integrated molecular tools are advancing understanding of the mechanistic pathways by which microplastics disrupt biological systems, offering a more comprehensive picture than single-endpoint toxicity studies.
A Review of Liquid Chromatography-Mass Spectrometry Strategies for the Analyses of Metabolomics Induced by Microplastics
This review summarized liquid chromatography-mass spectrometry strategies for analyzing metabolomic changes induced by microplastic exposure, covering analytical approaches for understanding how microplastics disrupt metabolic pathways in living organisms.
Review: Environmental toxicology of marine microplastic pollution — R0/PR2
This review examines the toxicological impacts of microplastics on marine organisms across trophic levels — from phytoplankton to fish — finding diverse biological effects at molecular, metabolic, and physiological levels, while calling for more environmentally relevant research methods.
A review of environmental metabolism disrupting chemicals and effect biomarkers associating disease risks: Where exposomics meets metabolomics
This review examines how environmental chemicals, including contaminants associated with plastics, can disrupt human metabolism and contribute to conditions like obesity and diabetes. Researchers mapped the connections between chemical exposure and changes in metabolic biomarkers that signal disease risk. The study highlights the emerging field of metabolism-disrupting chemicals and the importance of understanding how everyday environmental exposures influence long-term metabolic health.
A critical viewpoint on current issues, limitations, and future research needs on micro- and nanoplastic studies: From the detection to the toxicological assessment.
This critical review examines the current methods for detecting and characterizing micro- and nanoplastics in various environmental samples, as well as reported toxic effects from in vivo and in vitro studies. The authors found that while substantial effort has been made to understand microplastic behavior, the scientific community is still far from a complete understanding of how these particles behave in biological systems. The review calls for improved standardized protocols and more studies focused on uptake kinetics, accumulation, and biodistribution.
Metabolomics reveals the mechanism of polyethylene microplastic toxicity to Daphnia magna
Using metabolomics and traditional toxicology, researchers investigated how polyethylene microplastics of different sizes affect the water flea Daphnia magna. The study found that microplastic exposure disrupted amino acid metabolism, lipid metabolism, and energy pathways, with smaller particles generally causing more pronounced metabolic disturbances.
Pollution Biomarkers in the Framework of Marine Biodiversity Conservation: State of Art and Perspectives
This review examines how molecular and cellular biomarkers can be used to detect the effects of chemical pollution, including from microplastics, on marine organisms and biodiversity. The study highlights the importance of integrating biomarker data into environmental monitoring frameworks to better assess pollution impacts on marine ecosystems.
Assessment of biomarker-based ecotoxic effects in combating microplastic pollution - A review
This review examined the use of biomarker-based ecotoxicological approaches to assess the impacts of microplastic pollution across marine, freshwater, and terrestrial organisms. The authors argue that standardized biomarker frameworks are needed to quantify ecological harm from microplastics more effectively.
Microplastics: Environmental Occurrence and Analytical Challenges
This comprehensive literature review examines how microplastics — plastic particles between 1 micrometer and 5 mm — enter and move through ecosystems, and what analytical methods are used to detect them. Despite being found throughout the world, the environmental consequences and toxic effects of microplastics on living organisms are still not fully understood.
Current Advances in Evaluation of Microplastics in Environmental Toxicology
This review paper summarizes existing research on microplastics—tiny pieces of plastic smaller than 5 millimeters that are now found everywhere in our environment. These microscopic plastic particles are becoming a major pollution problem because they can harm wildlife and potentially threaten human health as they spread through land and water systems. Understanding how to detect and study these particles is important because they may be entering our food and water supply.
Sources and distributions of microplastics and the hazards to plants, animals and human health:A review.
This review examines the sources, distribution, and health impacts of microplastics on plants, animals, and humans. Researchers found that microplastics enter organisms through multiple exposure pathways and can adsorb heavy metals and persistent organic pollutants due to their large surface area, potentially amplifying adverse effects on metabolism and overall health.
Microplastics as an emerging threat to human health: Challenges and advancements in their detection
This review examined microplastics as an emerging threat to human health, highlighting their endocrine-disrupting properties, ability to accumulate pollutants, and the analytical challenges in accurately detecting and characterizing them across environmental and biological samples.
Microplastics: challenges of assessment in biological samples and their implication for in vitro and in vivo effects
This review examines the challenges of detecting and assessing microplastics in biological samples, noting that analytical limitations and lack of standardized methods hinder our understanding of health effects. The study highlights that humans are exposed to microplastics primarily through ingestion and inhalation, and that more long-term studies with standardized protocols are needed to understand the full scope of potential biological impacts.
Environmental toxicology of marine microplastic pollution
This review summarized a decade of research on the environmental toxicology of marine microplastic pollution across different ocean organisms and trophic levels. Researchers found that microplastics can accumulate in marine life from phytoplankton to fish, causing molecular, metabolic, and physiological harm. The study emphasizes that understanding these toxic effects is essential for assessing the broader ecological risks of plastic pollution in ocean environments.
Microplastic pollution: A potent threat for metabolic disruption in mammals
This review examines the evidence linking microplastic exposure to metabolic disruption, covering mechanisms by which microplastics and their associated chemical additives may interfere with hormonal regulation, glucose metabolism, and lipid homeostasis. The authors identify microplastics as a potent emerging threat to metabolic health.
Detection and degradation of microplastics in the environment: a review
This review covers methods for detecting and breaking down microplastics in the environment. Microplastics persist in ecosystems and pose potential risks to both human health and wildlife. The paper highlights the need for better tools and strategies to address this growing pollution problem.
Microplastics in Humans: A Critical Review of Biomonitoring Evidence and Immune–Metabolic Associations
This review critically evaluates the current evidence on microplastic detection in human tissues and biological fluids, focusing on methodological challenges and the potential biological mechanisms of action. Researchers found significant variation across studies due to differences in analytical techniques and sample handling protocols. The study highlights emerging evidence linking microplastic presence in the body to immune and metabolic disruptions, while noting that standardized detection methods are urgently needed.
Environmental prevalence, fate, impacts, and mitigation of microplastics—a critical review on present understanding and future research scope
This critical review evaluates the environmental prevalence, fate, impacts, and mitigation of microplastics across aquatic, atmospheric, and terrestrial environments as well as human tissues. It discusses membrane-based and other treatment technologies for microplastic removal, identifying persistent monitoring and standardization challenges.
Eco-toxicity of nano-plastics and its implication on human metabolism: Current and future perspective
This review examines the sources, bioaccumulation pathways, and potential health effects of nanoplastics on human metabolism. Researchers found that nanoplastics can enter the body primarily through ingestion of contaminated food and packaging, and evidence suggests they may interfere with metabolic pathways and contribute to organ dysfunction. The study highlights that significant knowledge gaps remain in assessing the human health risks of nanoplastic exposure.