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Papers
61,005 resultsShowing papers similar to Microplastics to Metabolomics: Understanding the environmental and health implications of plastic pollution
ClearMetabolomics Approach in Environmental Studies: Methodologies, Application and Challenges
This review examines how metabolomics, the study of small molecules in biological systems, is being applied to environmental research to understand how chemical pollutants including microplastics affect organism metabolism. The study highlights metabolomics as a valuable tool for assessing the biological effects of environmental exposures at the molecular level, helping researchers identify biomarkers of pollutant exposure in both wildlife and humans.
A metabolomics perspective on the effect of environmental micro and nanoplastics on living organisms: A review
This review examines how scientists use metabolomics, the study of small molecules produced by cellular processes, to understand the toxic effects of microplastics and nanoplastics on living organisms. The research shows that these plastic particles disrupt metabolism in consistent ways across species, affecting energy production, fat processing, and amino acid pathways. These shared metabolic disruptions across different organisms suggest that microplastics could cause similar metabolic problems in humans.
Study on toxicity effects of environmental pollutants based on metabolomics: A review
This review examines how metabolomics, a technology that measures changes in small molecules within organisms, is being used to study the toxic effects of environmental pollutants including microplastics, heavy metals, and pesticides. Researchers found that metabolomics can reveal subtle biological changes caused by pollutant exposure that traditional methods might miss. The study highlights metabolomics as a powerful tool for understanding how environmental contaminants disrupt normal biological processes at the molecular level.
Metabolomics-Based Insights Into the Toxicological Effects and Mechanisms of Microplastics: A Comprehensive Review.
This review of existing research shows that microplastics—tiny plastic particles found everywhere in our environment—can harm multiple body systems including the gut, brain, and reproductive organs. Scientists used a technique called metabolomics (studying how our body processes chemicals) to discover that microplastics disrupt normal metabolism, potentially affecting everything from digestion and brain function to fertility and child development. This research helps explain why microplastic pollution may be a serious health threat that requires urgent attention and solutions.
A Review of Liquid Chromatography-Mass Spectrometry Strategies for the Analyses of Metabolomics Induced by Microplastics
This review summarized liquid chromatography-mass spectrometry strategies for analyzing metabolomic changes induced by microplastic exposure, covering analytical approaches for understanding how microplastics disrupt metabolic pathways in living organisms.
Multi-Omics Approach on the Ecotoxicological Assessment of Microplastics
This review examines the application of multi-omics approaches — including genomics, transcriptomics, proteomics, and metabolomics — to the ecotoxicological assessment of microplastics in living organisms. The authors synthesize how these integrated molecular tools are advancing understanding of the mechanistic pathways by which microplastics disrupt biological systems, offering a more comprehensive picture than single-endpoint toxicity studies.
Metabolomics reveals the mechanism of polyethylene microplastic toxicity to Daphnia magna
Using metabolomics and traditional toxicology, researchers investigated how polyethylene microplastics of different sizes affect the water flea Daphnia magna. The study found that microplastic exposure disrupted amino acid metabolism, lipid metabolism, and energy pathways, with smaller particles generally causing more pronounced metabolic disturbances.
The toxicity of nanoparticles and their interaction with cells: an in vitro metabolomic perspective
This review examines how nanoparticles interact with human cells and cause toxic effects, using a technique called metabolomics to track changes in cell chemistry. Understanding nanoparticle toxicity is relevant to microplastic research because nanoplastics behave similarly to other nanoparticles, penetrating cells and disrupting normal metabolic processes.
Metabolomic Studies for the Evaluation of Toxicity Induced by Environmental Toxicants on Model Organisms
This review described how environmental metabolomics — measuring small-molecule profiles in model organisms — can be used to assess the toxicity of environmental contaminants including microplastics, heavy metals, and pesticides, and highlighted key organisms, methods, and data analysis approaches.
Microplastics in Humans: A Critical Review of Biomonitoring Evidence and Immune–Metabolic Associations
This review critically evaluates the current evidence on microplastic detection in human tissues and biological fluids, focusing on methodological challenges and the potential biological mechanisms of action. Researchers found significant variation across studies due to differences in analytical techniques and sample handling protocols. The study highlights emerging evidence linking microplastic presence in the body to immune and metabolic disruptions, while noting that standardized detection methods are urgently needed.
Microplastics: Environmental Occurrence and Analytical Challenges
This comprehensive literature review examines how microplastics — plastic particles between 1 micrometer and 5 mm — enter and move through ecosystems, and what analytical methods are used to detect them. Despite being found throughout the world, the environmental consequences and toxic effects of microplastics on living organisms are still not fully understood.
A review of environmental metabolism disrupting chemicals and effect biomarkers associating disease risks: Where exposomics meets metabolomics
This review examines how environmental chemicals, including contaminants associated with plastics, can disrupt human metabolism and contribute to conditions like obesity and diabetes. Researchers mapped the connections between chemical exposure and changes in metabolic biomarkers that signal disease risk. The study highlights the emerging field of metabolism-disrupting chemicals and the importance of understanding how everyday environmental exposures influence long-term metabolic health.
Metabolic impacts of polystyrene microplastics on the freshwater microalga Microcystis aeruginosa
Researchers used untargeted metabolomics to investigate how polystyrene microplastics of different sizes affect the freshwater cyanobacterium Microcystis aeruginosa at the metabolic level. They found that microplastic exposure disrupted lipid metabolism and amino acid biosynthesis pathways, with effects varying by particle size and concentration. The study reveals that microplastics can cause subtle but measurable biochemical changes in freshwater algae that may not be captured by standard ecotoxicology tests.
Review: Environmental toxicology of marine microplastic pollution — R0/PR2
This review examines the toxicological impacts of microplastics on marine organisms across trophic levels — from phytoplankton to fish — finding diverse biological effects at molecular, metabolic, and physiological levels, while calling for more environmentally relevant research methods.
Microplastics: challenges of assessment in biological samples and their implication for in vitro and in vivo effects
This review examines the challenges of detecting and assessing microplastics in biological samples, noting that analytical limitations and lack of standardized methods hinder our understanding of health effects. The study highlights that humans are exposed to microplastics primarily through ingestion and inhalation, and that more long-term studies with standardized protocols are needed to understand the full scope of potential biological impacts.
A critical viewpoint on current issues, limitations, and future research needs on micro- and nanoplastic studies: From the detection to the toxicological assessment.
This critical review examines the current methods for detecting and characterizing micro- and nanoplastics in various environmental samples, as well as reported toxic effects from in vivo and in vitro studies. The authors found that while substantial effort has been made to understand microplastic behavior, the scientific community is still far from a complete understanding of how these particles behave in biological systems. The review calls for improved standardized protocols and more studies focused on uptake kinetics, accumulation, and biodistribution.
Microplastic pollution: A potent threat for metabolic disruption in mammals
This review examines the evidence linking microplastic exposure to metabolic disruption, covering mechanisms by which microplastics and their associated chemical additives may interfere with hormonal regulation, glucose metabolism, and lipid homeostasis. The authors identify microplastics as a potent emerging threat to metabolic health.
Eco-toxicity of nano-plastics and its implication on human metabolism: Current and future perspective
This review examines the sources, bioaccumulation pathways, and potential health effects of nanoplastics on human metabolism. Researchers found that nanoplastics can enter the body primarily through ingestion of contaminated food and packaging, and evidence suggests they may interfere with metabolic pathways and contribute to organ dysfunction. The study highlights that significant knowledge gaps remain in assessing the human health risks of nanoplastic exposure.
Chemical Analysis of Microplastics and Nanoplastics: Challenges, Advanced Methods, and Perspectives
This review covers the latest laboratory methods for detecting and measuring microplastics and nanoplastics in environmental samples like water, food, and air. Identifying these tiny particles is extremely challenging because they vary enormously in size, shape, and plastic type, and concentrations can differ by billions of times between samples. Better standardized detection methods are essential for accurately understanding how much microplastic humans are actually exposed to.
Environmental toxicology of marine microplastic pollution
This review summarized a decade of research on the environmental toxicology of marine microplastic pollution across different ocean organisms and trophic levels. Researchers found that microplastics can accumulate in marine life from phytoplankton to fish, causing molecular, metabolic, and physiological harm. The study emphasizes that understanding these toxic effects is essential for assessing the broader ecological risks of plastic pollution in ocean environments.
A review on microplastics: sources, environmental fate, degradation pathways, and analytical identification methods.
This review paper summarizes existing research on tiny plastic particles called microplastics and how scientists detect them in the environment. Microplastics are a growing concern because they contaminate our air, water, and food, potentially affecting human health when we breathe or eat them. The researchers found that new, cheaper detection methods could help us better monitor these plastic particles and understand their impact on our health and environment.
Microplastics and Human Health: A Comprehensive Review on Exposure Pathways, Toxicity, and Emerging Risks
This comprehensive review examines microplastic exposure pathways in humans, methods of detection, and the potential toxic effects on various biological systems. The study highlights growing evidence that microplastics can enter the body through ingestion, inhalation, and dermal contact, and may affect multiple organ systems, though significant uncertainties remain about long-term health outcomes.
Current Advances in Evaluation of Microplastics in Environmental Toxicology
This review paper summarizes existing research on microplastics—tiny pieces of plastic smaller than 5 millimeters that are now found everywhere in our environment. These microscopic plastic particles are becoming a major pollution problem because they can harm wildlife and potentially threaten human health as they spread through land and water systems. Understanding how to detect and study these particles is important because they may be entering our food and water supply.
Mass spectrometry-based multimodal approaches for the identification and quantification analysis of microplastics in food matrix
This review examines mass spectrometry techniques for identifying and measuring microplastics in food, covering methods that analyze both the chemical composition and quantity of plastic particles. The study suggests these advanced analytical approaches could help bridge the gap between environmental monitoring and understanding actual human exposure levels. Better measurement tools are needed to assess how much microplastic people are consuming through their diet.