Papers

Microplastics exposure causes the senescence of human lung epithelial cells and mouse lungs by inducing ROS signaling

Researchers found that four common types of microplastics all caused premature aging (senescence) in human lung cells by increasing harmful reactive oxygen species, and that an antioxidant treatment could partially reverse this effect. When PVC microplastics were introduced into mouse lungs, the animals showed reduced physical function, increased body-wide inflammation, and accumulation of aged cells, suggesting that inhaling microplastics could accelerate lung aging.

Gastrointestinal problems in a valproic acid-induced rat model of autism: From maternal intestinal health to offspring intestinal function

Researchers studied gastrointestinal problems in a rat model of autism and found connections between maternal gut inflammation, disrupted gut bacteria, and digestive issues in offspring. The study suggests that intestinal health problems seen in autism spectrum conditions may have roots in the maternal environment during development. Further research is needed to better understand how maternal gut health influences digestive function in neurodevelopmental conditions.

Immune mechanism of gut microbiota and its metabolites in the occurrence and development of cardiovascular diseases

This review examines immune mechanisms linking gut microbiota and its metabolites to cardiovascular diseases, explaining how disruptions in the microbiota-immune balance contribute to conditions such as atherosclerosis, hypertension, and heart failure.

Single-cell transcriptomic dissection of the cellular and molecular events underlying the triclosan-induced liver fibrosis in mice

Researchers used single-cell analysis to map exactly which liver cell types are damaged by triclosan — a common antimicrobial found in personal care products — and found it activates star-shaped cells called hepatic stellate cells, leading to liver scarring (fibrosis). This is the first detailed cellular atlas of triclosan's toxic effects on the liver.

Cell uptake of mixtures of different-sized nanoplastics: Interplay and mechanism

Researchers studied how two sizes of polystyrene nanoplastics interact during cellular uptake, finding that larger 100 nm particles can pull smaller 50 nm particles into cells via clathrin-mediated endocytosis, while smaller particles alter the protein corona of larger ones in serum, either enhancing or inhibiting uptake depending on concentration ratios.

Microplastics and Dechlorane Plus Co-Exposure Amplifies Their Impacts on Soybean Plant

Jianwei Xiaoshi oral liquid attenuates high-calorie diet-induced dyspepsia in immature rats via regulating the pancreatic secretion pathway and maintaining the homeostasis of intestinal microbiota

Researchers found that a traditional Chinese herbal medicine formula called Jianwei Xiaoshi oral liquid improved functional digestive problems in young rats fed a high-calorie diet by regulating eight key proteins involved in pancreatic digestion and restoring healthy gut bacteria balance. The findings suggest potential therapeutic benefits of this herbal remedy for diet-induced digestive disorders in children.

MTX-PEG modified CG/DMMA polymeric micelles for targeted delivery of doxorubicin to induce synergistic autophagic death against triple negative breast cancer

Researchers developed methotrexate-polyethylene glycol (MTX-PEG) modified CG/DMMA polymeric micelles for targeted doxorubicin delivery to triple negative breast cancer (TNBC), aiming to reduce off-target toxicity and exploit synergistic autophagic cell death. The micelles effectively promoted autophagosome accumulation and disrupted autophagic flux in tumor cells, improving tumor-selective drug accumulation and anti-tumor efficacy in vitro.

Proteomic Insights into Composition-Dependent Effects of Microplastics on Freshwater Microalgae Chlamydomonas Reinhardtii