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Article Tier 2

Leaf absorption contributes to accumulation of microplastics in plants

Researchers found that plant leaves can absorb tiny plastic particles directly from the air, not just through the roots. Leafy vegetables grown outdoors in polluted areas contained measurable amounts of common plastics like PET and polystyrene. This means airborne microplastics may be entering our food supply through the plants we eat.

2025 Nature 102 citations
Systematic Review Tier 1

Microplastics in drinking water: A review on methods, occurrence, sources, and potential risks assessment

This systematic review found that microplastics are widespread in drinking water worldwide, with most particles smaller than 10 micrometers and composed of polyester, polyethylene, polypropylene, and polystyrene. Standardized sampling and analysis methods are urgently needed, as large variations in reported concentrations make it difficult to accurately assess health risks from drinking water exposure.

2024 Environmental Pollution 50 citations
Article Tier 2

Assessing the Efficacy of Pyrolysis–Gas Chromatography–Mass Spectrometry for Nanoplastic and Microplastic Analysis in Human Blood

Researchers tested whether a common lab technique (pyrolysis-gas chromatography-mass spectrometry) can reliably measure nanoplastics in human blood. They found that realistic detection limits were up to 20 times higher than ideal conditions suggest, and certain common plastics like polyethylene produced false readings due to interference from blood components. The study concludes that better analytical methods are needed before we can accurately measure plastic levels in human blood.

2025 Environmental Science & Technology 64 citations
Article Tier 2

Microplastics in human skeletal tissues: Presence, distribution and health implications

This study is the first to find microplastics in human bones, cartilage, and spinal discs, with the highest concentrations found in spinal discs. The most common plastics detected were polypropylene and polystyrene, and animal experiments confirmed that microplastics can reach skeletal tissues through the bloodstream. Exposure triggered inflammatory markers in the blood, suggesting microplastics in bones could contribute to skeletal health problems.

2025 Environment International 61 citations
Systematic Review Tier 1

Assessing the Impact of Nanoplastics in Biological Systems: Systematic Review of In Vitro Animal Studies

This systematic review of lab studies found that nanoplastics can damage cells in the gut, lungs, liver, brain, and reproductive organs of animals. These ultra-small plastic particles appear capable of crossing biological barriers and causing inflammation and oxidative stress, raising concerns about similar effects in humans.

2025 Journal of Xenobiotics 10 citations
Meta Analysis Tier 1

Non-degradable microplastic promote microbial colonization: A meta-analysis comparing the effects of microplastic properties and environmental factors

This meta-analysis found that non-degradable microplastics — particularly PVC and polystyrene — support significantly more microbial colonization and biofilm formation than degradable plastics. Smaller particles were more conducive to colonization, and environmental factors like temperature, salinity, and exposure duration became increasingly important over time, with ocean microplastics forming biofilms more easily than those in lakes.

2025 Environmental Research 14 citations
Systematic Review Tier 1

Impact of microplastics on the human gut microbiome: a systematic review of microbial composition, diversity, and metabolic disruptions

This systematic review of 12 studies found that microplastics including polyethylene, polystyrene, and PVC induce gut dysbiosis in humans, reducing beneficial bacteria and enriching pathogens. Microplastic exposure also impairs short-chain fatty acid production and modulates immune pathways, contributing to intestinal disease, metabolic syndrome, and chronic inflammation.

2025 BMC Gastroenterology 19 citations
Article Tier 2

Nanoplastic concentrations across the North Atlantic

Scientists measured nanoplastics (plastic particles smaller than a micrometer) across the entire North Atlantic Ocean for the first time. They found these tiny particles throughout the water column, with estimated amounts in the surface layer alone potentially reaching 27 million tonnes. This mass rivals or exceeds previous estimates for all larger plastics in the entire Atlantic, showing that nanoplastic pollution is far more extensive than previously thought.

2025 Nature 83 citations
Meta Analysis Tier 1

Risk Assessment of Microplastics in Humans: Distribution, Exposure, and Toxicological Effects

This meta-analysis tracked the rapid growth of research on microplastics and human health, finding a shift from studying environmental pollution toward understanding direct human exposure and health effects. Emerging concerns include reproductive toxicity, neurotoxicity, and immune system disruption from microplastic exposure.

2025 Polymers 10 citations
Article Tier 2

Biodegradation of Typical Plastics: From Microbial Diversity to Metabolic Mechanisms

This review examines how marine microorganisms, including bacteria and fungi, can naturally break down common plastics like PET, polystyrene, and polyethylene. Marine microbes may be better adapted than land-based organisms for this task because they already thrive in harsh conditions, offering a potential environmentally friendly approach to addressing ocean plastic pollution.

2024 International Journal of Molecular Sciences 115 citations
Article Tier 2

Effects of polystyrene, polyethylene, and polypropylene microplastics on the soil-rhizosphere-plant system: Phytotoxicity, enzyme activity, and microbial community

Researchers tested how three common types of microplastics (polystyrene, polyethylene, and polypropylene) affect lettuce growth and soil health. All three types inhibited plant growth, disrupted antioxidant systems in the leaves, and altered the microbial communities in the soil around roots, with polystyrene and polypropylene causing the most disturbance.

2024 Journal of Hazardous Materials 122 citations
Article Tier 2

Direct observation and identification of nanoplastics in ocean water

Researchers developed a new technique to directly see and identify nanoplastics (plastic particles smaller than a micrometer) in ocean water for the first time. They found nylon, polystyrene, and PET particles in samples from two oceans, appearing as tiny fibers, flakes, and other shapes made from plastics commonly used in everyday products.

2024 Science Advances 105 citations
Article Tier 2

Discovery and analysis of microplastics in human bone marrow

For the first time, researchers detected microplastics in human bone marrow, finding plastic particles in all 16 samples tested. The most common types were polyethylene and polystyrene, with about 90% of particles smaller than 100 micrometers. This discovery shows that microplastics can penetrate deep into the body and reach the tissue where blood cells are made, raising questions about potential effects on blood cell production and immune function.

2024 Journal of Hazardous Materials 104 citations
Article Tier 2

Quantitation and identification of microplastics accumulation in human placental specimens using pyrolysis gas chromatography mass spectrometry

Researchers analyzed 62 human placenta samples and found microplastics in every single one, with concentrations ranging from 6.5 to 685 micrograms per gram of tissue. Polyethylene, the most common plastic in everyday products, made up 54% of the plastics found. This widespread presence of microplastics in placentas raises concerns about fetal exposure during pregnancy and potential effects on development.

2024 Toxicological Sciences 194 citations
Systematic Review Tier 1

Nano- and microplastics commonly cause adverse impacts on plants at environmentally relevant levels: A systematic review

Systematic review of 78 studies found that nano- and microplastics commonly cause adverse effects on plants even at environmentally relevant concentrations, with germination and root growth more strongly affected than shoot growth during early development. Chlorophyll levels were consistently reduced while stress indicators (ROS) and antioxidant enzymes were consistently upregulated across species.

2023 The Science of The Total Environment 100 citations
Article Tier 2

Endoplasmic reticulum stress-induced NLRP3 inflammasome activation as a novel mechanism of polystyrene microplastics (PS-MPs)-induced pulmonary inflammation in chickens

Researchers exposed chickens to polystyrene microplastics for 42 days and found significant lung damage, including tissue inflammation and cell stress responses. The microplastics triggered a chain reaction starting with stress in the endoplasmic reticulum (a cell structure involved in protein processing) that activated inflammatory pathways. While this study focused on poultry, similar inflammatory mechanisms could be relevant to understanding how microplastics affect lungs in other species, including humans.

2024 Journal of Zhejiang University SCIENCE B 123 citations
Systematic Review Tier 1

Can Mammalian Reproductive Health Withstand Massive Exposure to Polystyrene Micro- and Nanoplastic Derivatives? A Systematic Review

This systematic review examined how polystyrene micro- and nanoplastics affect reproductive health in mammals. The evidence from animal studies shows these particles can cause oxidative stress, inflammation, and hormonal imbalances in reproductive organs, raising concerns about potential effects on human fertility.

2024 International Journal of Molecular Sciences 21 citations
Clinical Trial Tier 1

Disturbance of mitochondrial dynamics led to spermatogenesis disorder in mice exposed to polystyrene micro- and nanoplastics

Polystyrene micro- and nanoplastics caused spermatogenesis disorders in mice by disrupting mitochondrial dynamics, triggering excessive mitochondrial fission that activated both apoptosis and pyroptosis pathways in testicular tissue. Nanoplastics caused mitochondrial DNA to leak into the cytoplasm, activating the cGAS-STING inflammatory pathway — a mechanism confirmed by rescue experiments with a mitochondrial fission inhibitor.

2024 Environmental Pollution 22 citations
Meta Analysis Tier 1

Microplastics alter the equilibrium of plant-soil-microbial system: A meta-analysis

This meta-analysis pools data from multiple studies to show that microplastics disrupt the balance between plants, soil, and soil microbes. The effects vary depending on the type, size, and concentration of microplastics, suggesting that these tiny plastic particles can alter how nutrients cycle through the soil and ultimately affect the food we grow.

2024 Ecotoxicology and Environmental Safety 23 citations
Article Tier 2

Microplastics in human blood: Polymer types, concentrations and characterisation using μFTIR

Scientists analyzed blood from 20 healthy volunteers and found microplastics in 90% of samples, identifying 24 different plastic types including many reported for the first time in blood. The particles were mostly small fragments averaging about 128 micrometers long, and the study also detected hormone-disrupting chemicals called phthalates attached to the plastics. This adds to growing evidence that a wide variety of plastic particles are circulating in human blood.

2024 Environment International 178 citations
Article Tier 2

Polystyrene Nanoplastics Activate Autophagy and Suppress Trophoblast Cell Migration/Invasion and Migrasome Formation to Induce Miscarriage

In mouse and cell studies, polystyrene nanoplastics at doses near real-world human exposure levels caused miscarriage by blocking the movement of placental cells needed for a healthy pregnancy. The nanoplastics triggered a cellular recycling process called autophagy that broke down key proteins required for placental cell migration and invasion.

2024 ACS Nano 103 citations
Article Tier 2

MicroRaman spectroscopy detects the presence of microplastics in human urine and kidney tissue

Scientists confirmed for the first time that microplastics accumulate in human kidney tissue, finding 26 plastic particles in kidney and urine samples using advanced spectroscopy. The most common plastics found were polyethylene and polystyrene, with particles ranging from 1 to 29 micrometers in kidneys, providing the first direct evidence that microplastics can deposit in human kidneys.

2024 Environment International 172 citations
Article Tier 2

Features, Potential Invasion Pathways, and Reproductive Health Risks of Microplastics Detected in Human Uterus

Researchers found microplastics in the uterine lining of 22 women, identifying common plastics like polyamide, polyurethane, and PET in sizes ranging from 2 to 200 micrometers. In mouse experiments, microplastic exposure led to reduced fertility, abnormal offspring sex ratios, and significant uterine inflammation. These findings raise serious concerns about the potential impact of microplastic contamination on female reproductive health and pregnancy outcomes.

2024 Environmental Science & Technology 118 citations
Systematic Review Tier 1

A review of potential human health impacts of micro- and nanoplastics exposure

This systematic review summarized 133 studies on how micro- and nanoplastics affect human health based on mammalian research. The evidence points to cell damage, inflammation, gut disruption, and reproductive harm, though most studies focused on polystyrene particles and more research is needed on other common plastic types.

2022 The Science of The Total Environment 211 citations