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Plastic-Degrading Microorganisms: Biodegradation Pathways and Habitat Origins

Molecules 2026
Martyna Jowita Żarska, Marcin Damian Jasiak, Patryk Mierzejewski, Klaudiusz Tomczyk, Jakub Małecki, Roksana Gudz, Aneta Krystyna Urbanek, Katarzyna E. Kosiorowska, Julia Alicja Dybka

Summary

Scientists have found that certain bacteria and fungi—living in places like landfills, soil, and compost—naturally produce enzymes that can break down different types of plastic, essentially "eating" them as food. This matters because plastic pollution (including the microplastics we're increasingly exposed to in food, water, and air) is a growing health concern, and these microbes could offer a natural, eco-friendly way to clean up plastic waste instead of relying on landfills or incineration. This paper is a review, meaning it summarizes and organizes findings from existing studies rather than presenting brand-new experiments.

Microbial biodegradation represents a promising approach to addressing global plastic pollution, yet the metabolic pathways and environmental origins of polymer-degrading microorganisms remain incompletely characterized. This review synthesizes current knowledge on biodegradation mechanisms across major polymer classes and identifies key environmental reservoirs harboring native plastic-degrading microbiota. Biodegradation pathways differ fundamentally according to polymer chemistry. Polyesters such as PET undergo hydrolytic cleavage by PETases and MHETases, releasing terephthalic acid and ethylene glycol for assimilation via the β-ketoadipate pathway and the TCA cycle. Biodegradable polyesters (PLA, PBAT, PHAs, PCL) are similarly hydrolyzed by cutinases, lipases, and depolymerases. In contrast, polyolefins (PE, PP) and polystyrene lack hydrolyzable bonds and require oxidative attack by laccases, peroxidases, and alkane monooxygenases, followed by β-oxidation to acetyl-CoA. Three principal environmental reservoirs supply plastic-degrading microorganisms: contaminated ecosystems including landfills and the plastisphere; soil microbiota contributing ligninolytic fungi and actinomycetes; and compost environments yielding thermostable enzymes such as leaf-branch compost cutinase. Across all environments, microbial consortia demonstrate superior degradation efficiency compared to single-species cultures, reflecting the enzymatic complexity required for complete polymer mineralization. Understanding these pathways and their environmental origins provides a foundation for biological plastic waste management strategies.

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