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61,005 resultsShowing papers similar to Maternal exposure to polystyrene nanoplastics leads to ovotoxicity in female mouse offspring
ClearMaternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring
When pregnant mice were exposed to nanoplastics during pregnancy and nursing, their female offspring had significantly reduced fertility as adults. The nanoplastics caused premature activation of egg cells in the ovaries and damaged crucial connections between eggs and their supporting cells. This raises concerns that a mother's exposure to nanoplastics could have lasting effects on her daughters' ability to have children.
Exposure to Polystyrene Nanoplastics Compromise Ovarian Reserve Function and Endometrial Decidualization in Early Pregnant Mice
Female mice exposed to polystyrene nanoplastics for 90 days before pregnancy had fewer successful pregnancies, smaller pups, and damaged ovaries with reduced egg counts. The nanoplastics disrupted key reproductive hormones and interfered with the uterine process needed for embryo implantation. This study raises concerns that nanoplastic exposure through food and water could harm female fertility and pregnancy outcomes in humans.
Maternal exposure to polystyrene nanoplastics impacts developmental milestones and brain structure in mouse offspring
Researchers exposed pregnant mice to polystyrene nanoplastics and studied the effects on their offspring's brain development. The study found that maternal nanoplastic exposure affected developmental milestones and brain structure in the young mice. The findings suggest that nanoplastic exposure during pregnancy may pose risks to fetal brain development, though more research is needed to understand the implications for humans.
Effects of polystyrene nanoplastics on the female reproductive system in mice: Implications for ovarian function and follicular development
Researchers exposed female mice to polystyrene nanoplastics orally for 29 days and examined the effects on their reproductive systems. They found that nanoplastic exposure disrupted estrous cycles, impaired follicle development, and altered hormone levels in a dose-dependent manner. The study suggests that nanoplastics, due to their extremely small size, may cross biological barriers and accumulate in reproductive tissues, raising concerns about potential effects on fertility.
The ovarian-related effects of polystyrene nanoplastics on human ovarian granulosa cells and female mice
This study tested the effects of polystyrene nanoplastics on both human ovarian cells in the lab and on female mice. The nanoplastics accumulated in ovarian tissue, caused cell death, disrupted hormone levels, and reduced egg quality and fertility in mice. These findings suggest that nanoplastic exposure could threaten female reproductive health by damaging the ovaries.
Transplacental and lactational transfer of polystyrene nanoplastics leads to long-term ovarian impairment in rat offspring
Researchers found that polystyrene nanoplastics crossed the placental barrier in rats and accumulated in fetal and postnatal ovaries, causing dose-dependent damage to follicle development and ovarian structure. Exposed offspring showed reduced primordial follicle numbers, granulosa cell disorganization, and hormonal imbalances that persisted through postnatal day 60. The study suggests that maternal nanoplastic exposure during pregnancy and lactation may have long-lasting effects on female reproductive development.
Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny
When pregnant mice were exposed to polystyrene nanoplastics, their offspring showed abnormal brain development including changes in neural stem cell function, altered brain structure, and cognitive problems. The effects were gender-specific, with some deficits appearing more strongly in one sex. This study raises concerns that nanoplastic exposure during pregnancy could increase the risk of neurodevelopmental problems in children.
Toxicity of polystyrene nanoparticles for mouse ovary and cultured human granulosa cells
Researchers investigated the effects of polystyrene nanoparticles on female reproductive health using both mouse ovaries and human granulosa cell cultures. They found that nanoparticle exposure damaged ovarian tissue, reduced egg quality, and triggered cell death through oxidative stress and inflammation pathways. The study suggests that nanoplastic exposure may pose risks to female fertility, though more research is needed to confirm effects at real-world exposure levels.
Polystyrene microplastics induced female reproductive toxicity in mice
Researchers exposed female mice to polystyrene microplastics for 35 days and found the particles accumulated in multiple organs including the ovaries, where they caused inflammation and oxidative stress. The microplastics reduced egg quality by lowering protective antioxidants, disrupting mitochondrial function, and altering calcium levels in the cells. This study provides evidence that microplastic exposure could harm female fertility by directly damaging the ovaries and the eggs they produce.
Maternal exposure to polystyrene nanoplastics during gestation and lactation induces hepatic and testicular toxicity in male mouse offspring
Researchers exposed pregnant and nursing mice to polystyrene nanoplastics and studied the effects on their male offspring. The offspring showed reduced body weight, liver damage with inflammation and disrupted sugar metabolism, and testicular harm including decreased sperm counts. The findings suggest that nanoplastic exposure during pregnancy and breastfeeding can cause significant organ damage in the next generation.
Maternal polystyrene nanoplastics exposure during pregnancy induces obesity development in adult offspring through disrupting lipid homeostasis
Researchers found that maternal inhalation exposure to polystyrene nanoplastics during pregnancy induced obesity development in adult offspring of mice, suggesting in utero exposure to airborne nanoplastics programs metabolic dysfunction. The study linked prenatal nanoplastic exposure to increased adiposity and metabolic changes persisting into adulthood.
Intergenerational and transgenerational reproductive toxicity of polystyrene microplastics in female mice
Female mice were exposed to polystyrene microplastics during lactation and researchers tracked reproductive outcomes in both exposed mothers and their offspring through multiple generations, finding that even at doses comparable to human infant bottle-feeding exposure, microplastics induced ovarian damage and reduced fertility that persisted across generations.
Polystyrene and polyethylene terephthalate nanoplastics differentially impact mouse ovarian follicle function
Researchers tested how polystyrene and polyethylene terephthalate (PET) nanoplastics affect mouse ovarian follicles at environmentally relevant doses. They found that both types inhibited follicle growth and altered gene expression related to hormone production and oxidative stress, with PET nanoplastics specifically disrupting steroid hormone pathways. The study suggests that different plastic types may affect female reproductive health through distinct mechanisms.
Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny
Researchers found that maternal exposure to polystyrene nanoplastics caused brain abnormalities in offspring, demonstrating that nanoplastics can cross maternal barriers and affect neurological development in progeny with implications for developmental toxicology.
Exposure to polystyrene nanoplastics impairs sperm metabolism and pre-implantation embryo development in mice
This study found that male mice given polystyrene nanoplastics by mouth showed significant harm to sperm function and early embryo development, with changes in gene expression that could affect offspring. The findings raise concerns that nanoplastic exposure could impair male fertility and potentially pass harmful effects to the next generation.
Effects of polystyrene nanoplastic gestational exposure on mice
Researchers exposed pregnant mice to airborne polystyrene nanoplastics and studied the effects on both mothers and offspring. High-dose exposure caused fatty liver disease in the mothers and in adult female offspring, but not in male offspring, with each group showing different underlying molecular mechanisms. The study suggests that prenatal exposure to airborne nanoplastics may have sex-specific effects on metabolic health that persist into adulthood.
Polystyrene nanoplastics induce apoptosis, autophagy, and steroidogenesis disruption in granulosa cells to reduce oocyte quality and fertility by inhibiting the PI3K/AKT pathway in female mice
Researchers found that polystyrene nanoplastics (tiny plastic particles under 1 micrometer) impair egg cell quality in female mice by damaging the ovarian support cells that help eggs mature, triggering cell death and disrupting hormone production. These findings raise important questions about the potential reproductive risks of nanoplastic exposure in women.
Maternal exposure to polystyrene nanoparticles retarded fetal growth and triggered metabolic disorders of placenta and fetus in mice
Researchers exposed pregnant mice to polystyrene nanoplastics through drinking water and found that higher concentrations led to significantly reduced fetal weight. The nanoplastics caused abnormal cell structures in the placenta and disrupted metabolic processes in both placental tissue and fetal livers. The study suggests that maternal nanoplastic exposure during pregnancy can cross the placental barrier and interfere with normal fetal growth and metabolism.
Polystyrene microplastics impaired decidualization in mice via oxidative stress and inflammation and disrupted the reproductive function of their female offspring
Mouse experiments found that polystyrene microplastics impaired uterine decidualization and embryo implantation via oxidative stress and inflammation, and that maternal PS-MP exposure also disrupted the reproductive function of female offspring.
Polystyrene and polyethylene terephthalate nanoplastics differentially impact mouse ovarian follicle function
Researchers exposed mouse ovarian follicles to polystyrene and polyethylene terephthalate nanoplastics at environmentally relevant concentrations and found both impaired follicle development and hormone production, with PET causing more severe effects — raising concerns given its widespread use in food packaging.
Maternal Exposure to Polystyrene Micro- and Nanoplastics Causes Fetal Growth Restriction in Mice
Researchers exposed pregnant mice to polystyrene micro and nanoplastics and found that exposure caused fetal growth restriction and placental abnormalities. The study observed that plastic particles accumulated in placental tissue and disrupted normal placental function. These findings raise concern that maternal exposure to plastic particles during pregnancy may interfere with fetal development.
Impact of polystyrene microplastics (PS-MPs) on the entire female mouse reproductive cycle: Assessing reproductive toxicity of microplastics through in vitro follicle culture
Female mice exposed to polystyrene microplastics suffered significant damage to their reproductive systems, including ovarian cell death, abnormal egg development, and fewer offspring. The microplastics accumulated in the ovaries and triggered cell death pathways while disrupting survival signaling in the cells that support egg development, suggesting microplastic exposure could contribute to declining fertility.
Effects of orally administered polystyrene nanoplastics on reproduction and development in rodents
This study examined the reproductive and developmental effects of orally administered polystyrene nanoplastics in an animal model, finding that NP ingestion impaired fertility metrics and offspring development, contributing to growing evidence of nanoplastic reproductive toxicity.
Teratological, neurochemical and histomorphic changes in the limbic areas of F1 mice progeny due to co-parental polystyrene nanoplastic exposure
Researchers exposed parent mice to polystyrene nanoplastics before and during pregnancy and found that offspring exhibited skeletal and visceral malformations, impaired neonatal reflexes, learning deficits, and structural brain changes — including reduced hippocampal neurons — demonstrating transgenerational neurodevelopmental harm from nanoplastic exposure.