Article
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Tier 2
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Original research — experimental, observational, or case-control study. Direct primary evidence.
Nanoplastics
Reproductive & Development
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Polystyrene nanoplastics induce apoptosis, autophagy, and steroidogenesis disruption in granulosa cells to reduce oocyte quality and fertility by inhibiting the PI3K/AKT pathway in female mice
Journal of Nanobiotechnology2024
51 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 70
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0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Researchers found that polystyrene nanoplastics (tiny plastic particles under 1 micrometer) impair egg cell quality in female mice by damaging the ovarian support cells that help eggs mature, triggering cell death and disrupting hormone production. These findings raise important questions about the potential reproductive risks of nanoplastic exposure in women.
This study provides findings on how PS-NPs impact ovarian function and include transcriptome sequencing analysis of ovarian tissue. The study demonstrates that PS-NPs impair oocyte quality by altering the functioning of ovarian granulosa cells. Therefore, it is necessary to focus on the research on the effects of PS-NPs on female reproduction and the related methods that may mitigate their toxicity.