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61,005 resultsShowing papers similar to Agrocybe cylindracea Polysaccharides Ameliorate DSS-Induced Colitis by Restoring Intestinal Barrier Function and Reprogramming Immune Homeostasis via the Gut–Liver Axis
ClearBlack Lycium barbarum polysaccharide attenuates LPS-induced intestine damage via regulation gut microbiota
Researchers studied whether a polysaccharide from black Lycium barbarum could protect against intestinal damage caused by bacterial toxins in mice. They found that the supplement alleviated intestinal tissue damage and improved gut microbiota diversity by promoting beneficial bacteria. The study suggests that this plant-derived polysaccharide may help maintain intestinal health by modulating the gut microbial community.
Multi-Omics Analysis of the Gut-Liver Axis Reveals the Mechanism of Liver Injury in Colitis Mice
Researchers used multi-omics analysis to reveal that liver injury in colitis mice is linked to intestinal dysbiosis and altered host-microbiota interactions, with gut bacterial shifts correlating to immune and metabolic changes in the liver.
Effects of repeated intragastric administrations with heat-inactivated Mycobacterium aurum DSM 33539 on the stress-induced aggravation of dextran sulfate sodium (DSS) colitis in C57BL/6N mice
Researchers tested whether a heat-inactivated preparation of the soil bacterium Mycobacterium aurum could protect mice from stress-aggravated intestinal inflammation. They found that oral administration of M. aurum reduced the severity of stress-induced colitis and helped maintain intestinal barrier integrity. The study suggests that certain beneficial environmental bacteria may help protect gut health under stressful conditions, though more research is needed.
Lactobacillus plantarum A3 attenuates ulcerative colitis by modulating gut microbiota and metabolism
Researchers showed that Lactobacillus plantarum A3, a probiotic strain isolated from horses, reduced symptoms of ulcerative colitis in mice whose gut microbiomes had been disrupted by antibiotics. The probiotic restored beneficial bacteria like Akkermansia, reduced gut inflammation, and increased levels of natural anti-inflammatory compounds in the body.
Protocatechuic Acid Alleviates Dextran-Sulfate-Sodium-Induced Ulcerative Colitis in Mice via the Regulation of Intestinal Flora and Ferroptosis
Researchers found that protocatechuic acid, a naturally occurring compound found in many fruits and vegetables, helped alleviate ulcerative colitis in mice by restoring healthy gut bacteria and reducing a type of cell death called ferroptosis. The treatment improved intestinal barrier integrity and reduced inflammation. This is relevant to microplastics research because gut barrier damage is a key concern with microplastic ingestion.
Seaweed polysaccharide relieves hexavalent chromium-induced gut microbial homeostasis
Researchers found that seaweed polysaccharides can restore gut microbial balance disrupted by hexavalent chromium exposure in mice, reducing pathogenic bacteria and increasing beneficial species, suggesting a potential dietary intervention for heavy metal-induced intestinal damage.
Selenium-containing polysaccharide from Spirulina platensis alleviates Cd-induced toxicity in mice by inhibiting liver inflammation mediated by gut microbiota
Researchers found that selenium-containing polysaccharide from Spirulina platensis alleviates cadmium-induced liver toxicity in mice by modulating gut microbiota composition and suppressing inflammatory pathways, suggesting a protective role against heavy metal exposure.
Inhibitory Effects of Jiuzao Polysaccharides on Alcoholic Fatty Liver Formation in Zebrafish Larvae and Their Regulatory Impact on Intestinal Microbiota
Researchers investigated the protective effects of Laowuzeng Jiuzao polysaccharides on ethanol-induced alcoholic fatty liver in zebrafish larvae, finding that the polysaccharides reduced hepatic damage and regulated intestinal microbiota composition, suggesting therapeutic potential for alcohol-related liver disease.
Cyclic Oligosaccharide-Induced Modulation of Immunoglobulin A Reactivity to Gut Bacteria Contributes to Alterations in the Bacterial Community Structure
Researchers investigated whether dietary cyclic oligosaccharides — including cyclic nigerosyl-1,6-nigerose and three cyclodextrins — alter the immunoglobulin A coating of gut bacteria and whether this contributes to observed shifts in gut bacterial community composition in mice over 12 weeks. They found that each cyclic oligosaccharide altered both gut bacterial composition and IgA coating indices at the phylum and genus levels, with significant positive correlations between IgA coating and relative abundance observed for Bacillota and several Lachnospiraceae genera.
Gut Microbiota Participates in Polystyrene Microplastics-Induced Hepatic Injuries by Modulating the Gut–Liver Axis
This mouse study showed that polystyrene microplastics cause liver damage partly through disrupting gut bacteria, which then triggers harmful signals along the gut-liver connection. When researchers eliminated gut bacteria with antibiotics, liver damage from microplastics was reduced, confirming the gut microbiome plays a key role. Green tea extract (EGCG) helped protect the liver by restoring healthy gut bacteria, suggesting diet may help counteract some effects of microplastic exposure.
Research progress on the role of gut microbiota dysbiosis in the pathogenesis of immune−mediated liver diseases
This research review shows that an unhealthy gut microbiome (the bacteria living in your intestines) can trigger serious liver diseases where your immune system attacks your own liver. When gut bacteria are out of balance, harmful substances can leak into your bloodstream and cause dangerous inflammation in the liver. The good news is that treatments like probiotics and fecal transplants that restore healthy gut bacteria are showing promise for preventing and treating these liver diseases.
Modulation of Gut Microbial Metabolism by Cyanidin-3-O-Glucoside in Mitigating Polystyrene-Induced Colonic Inflammation: Insights from 16S rRNA Sequencing and Metabolomics
A natural plant compound called cyanidin-3-O-glucoside (C3G), found in red bayberry and other berries, reduced colon inflammation caused by polystyrene microplastic exposure in mice. C3G worked by reshaping the gut bacteria community and restoring healthy levels of anti-inflammatory signaling molecules. This suggests that certain dietary antioxidants may help protect the gut from damage caused by microplastic exposure.
Sodium acetate/sodium butyrate alleviates lipopolysaccharide-induced diarrhea in mice via regulating the gut microbiota, inflammatory cytokines, antioxidant levels, and NLRP3/Caspase-1 signaling
Researchers found that sodium acetate and sodium butyrate supplementation alleviated lipopolysaccharide-induced diarrhea in mice by restoring gut microbiota balance, reducing inflammatory cytokines, enhancing antioxidant levels, and inhibiting the NLRP3/Caspase-1 signaling pathway.
Korean red ginseng extract inhibits microplastic translocation via the gut−liver axis by ameliorating alcohol-induced intestinal disruption
Using a mouse model of alcohol-induced intestinal disruption, researchers found that Korean red ginseng extract reduced translocation of polystyrene microplastics from the gut to the liver by ameliorating alcohol-induced intestinal barrier damage, suggesting a potential protective role for this herbal extract.
Ameliorative effects of mulberry fruit anthocyanin extract on gut microbiota and liver metabolites in high-fat and high-cholesterol diet-fed ApoE−/− mice
Researchers investigated mulberry anthocyanin extract in high-fat, high-cholesterol diet-fed mice and found it reduced LDL cholesterol and inflammatory markers while favorably shifting gut microbial composition and modulating liver metabolites including glutamine and ATP, suggesting a mechanism linking gut microbiota to atherosclerosis risk reduction.
Sodium Humate Alleviates Enterotoxigenic Escherichia coli-Induced Intestinal Dysfunction via Alteration of Intestinal Microbiota and Metabolites in Mice
Researchers found that sodium humate supplementation alleviated intestinal damage caused by enterotoxigenic Escherichia coli infection in mice by improving gut microbiota composition, modulating metabolites, and reducing intestinal inflammation and barrier dysfunction.
Gut microbiota and liver metabolomics reveal the potential mechanism of Lactobacillus rhamnosus GG modulating the liver toxicity caused by polystyrene microplastics in mice
Researchers found that the probiotic Lactobacillus rhamnosus GG helped protect mice from liver damage caused by polystyrene microplastic exposure. The probiotic worked by restoring healthy gut bacteria and normalizing liver metabolic pathways disrupted by the microplastics. The study suggests that supporting gut health through beneficial bacteria may help mitigate some of the toxic effects microplastics have on the liver.
Lactiplantibacillus plantarum ZP-6 mitigates polystyrene nanoplastics-induced liver damage in colitis mice via the gut-liver axis
The probiotic strain Lactiplantibacillus plantarum ZP-6 mitigated polystyrene nanoplastic-induced liver injury in an animal model through multiple mechanisms including toxin binding, barrier enhancement, and anti-inflammatory activity, suggesting probiotics as a potential strategy for reducing nanoplastic health impacts.
A probiotic for preventing microplastic toxicity: Clostridium dalinum mitigates microplastic-induced damage via microbiota-metabolism-barrier interactions
Using metagenomics and metabolomics, this study found that the probiotic bacterium Clostridium dalinum reduced microplastic-induced gut damage in mice by modulating gut microbiota composition, metabolic pathways, and intestinal barrier integrity.
A Single Strain of Lactobacillus (CGMCC 21661) Exhibits Stable Glucose- and Lipid-Lowering Effects by Regulating Gut Microbiota
Researchers identified a novel Lactobacillus strain (CGMCC 21661) that outperformed fecal microbiota transplantation and Bifidobacterium in lowering blood glucose and lipids in diabetic mice, demonstrating stable therapeutic effects through gut microbiota regulation.
Cordyceps militaris solid medium extract alleviates lipopolysaccharide-induced acute lung injury via regulating gut microbiota and metabolism
Researchers found that an extract from Cordyceps militaris fungus reduced lung injury in mice by improving gut bacteria balance and correcting metabolic disorders. While not about microplastics, the study is relevant because it demonstrates the gut-lung connection and how gut microbiota health influences inflammatory lung conditions. Since microplastic exposure is known to disrupt gut bacteria, understanding gut-lung pathways could help explain how inhaled or ingested microplastics affect respiratory health.
Dexmedetomidine alleviates intestinal barrier dysfunction and inflammatory response in mice via suppressing TLR4/MyD88/NF-κB signaling in an experimental model of ulcerative colitis
Researchers investigated whether dexmedetomidine (DEX), a sedative agent, alleviates intestinal barrier dysfunction and inflammatory responses in a mouse model of ulcerative colitis, finding that DEX suppresses the TLR4/MyD88/NF-kB signaling pathway to reduce epithelial cell apoptosis and inflammation. The results suggest that DEX may have therapeutic potential for protecting intestinal barrier integrity in inflammatory bowel conditions.
Active compounds of licorice ameliorate microplastics-induced intestinal damage by targeting FADD
Researchers tested whether active compounds from licorice root could protect intestinal cells from damage caused by microplastic exposure in mice, finding that licorice compounds reduced inflammation and oxidative stress in the gut and partially restored intestinal barrier integrity.
Carvacrol attenuated lipopolysaccharide-induced intestinal injury by down-regulating TLRs gene expression and regulating the gut microbiota in rabbit
This study examined how carvacrol (a natural plant compound) reduces intestinal inflammation and protects gut microbiota in rabbits challenged with bacterial toxins. Understanding how the gut microbiome responds to different stressors provides context for research on microplastic effects on intestinal health.