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Article Tier 2

La Révision de REACH : Quels Impacts sur la Santé Humaine, l'Environnement et l'Industrie Attendus?

This study examines the anticipated impacts of the revision of the European REACH regulation on human health, environmental protection, and industrial practices. The analysis addresses how updated chemical regulations are expected to affect the management of hazardous substances including plastic additives and pollutants across the value chain.

2024 SPIRE - Sciences Po Institutional REpository
Article Tier 2

Chemicals management approach to sustainable development of materials

This review examines how chemicals management approaches must evolve for sustainable materials development, arguing that planetary boundaries and path-dependent industrial trajectories require rethinking how chemicals including plastics are produced and regulated.

2023 MRS Bulletin 12 citations
Article Tier 2

Environmental and health hazards of chemicals in plastic polymers and products

Researchers reviewed the environmental and health hazards of chemicals in plastic polymers and products, examining the toxicological profiles of monomers, additives, and degradation products that can leach from plastics into food, water, and the environment. The study identifies numerous plastic-associated chemicals with endocrine-disrupting, carcinogenic, or developmental toxicity potential and calls for more comprehensive safety testing of plastic formulations.

2011 Gothenburg University Publications Electronic Archive (Gothenburg University) 64 citations
Article Tier 2

Legal and Safety Issues of ECs

This chapter reviews the legal and safety frameworks surrounding emerging contaminants such as microplastics, pesticides, and flame retardants, noting significant regulatory gaps and the risks posed by their increasing environmental prevalence.

2024 1 citations
Article Tier 2

Regulating chemicals globally is key to a successful plastics treaty

This review argued that a successful global plastics treaty must regulate the more than 16,000 chemicals used across the plastic life cycle, not just the plastics themselves, as thousands of these chemicals meet criteria for persistence, bioaccumulation, and toxicity yet remain largely unregulated.

2025 Cambridge Prisms Plastics
Article Tier 2

Assessing and managing environmental hazards of polymers: historical development, science advances and policy options

Researchers critically reviewed how polymer environmental safety regulations, largely unchanged since the 1990s, fail to keep pace with scientific understanding of plastic pollution. They identified four key areas needing regulatory attention, including better transparency about polymer identities, improved understanding of environmental fate across size categories, and more comprehensive hazard assessments. The study suggests that current regulatory frameworks worldwide need significant updates to adequately manage the environmental risks posed by polymers.

2022 Environmental Science Processes & Impacts 46 citations
Article Tier 2

REACHing for divergence?—UK chemical regulation post-Brexit

This paper is not directly about microplastics; it analyzes how UK chemical regulation has diverged from EU REACH standards since Brexit, finding that the UK is falling behind the EU's pace of regulatory action on hazardous chemicals. While broadly relevant to environmental protection, the study does not address microplastics specifically.

2024 Integrated Environmental Assessment and Management 3 citations
Article Tier 2

Toxicity of plastic consumer products: a biological, chemical and social-ecological analysis

This study analyzed the toxic chemicals found in consumer plastic products, including additives, monomers, and processing by-products that can leach into food or the environment. The findings highlight that plastic toxicity extends beyond microplastic particles themselves — the chemicals embedded in plastics pose significant health risks through food packaging and environmental contamination.

2021
Review Tier 2

Chemical safety of food products: problems and solutions (literature review)

This literature review examines chemical safety challenges in food production and processing, covering contamination by pesticides, heavy metals, mycotoxins, and emerging pollutants including microplastics, and discussing regulatory and technological solutions.

2025 Toxicological Review
Article Tier 2

Plastic additives and microplastics as emerging contaminants: Mechanisms and analytical assessment

Researchers reviewed how chemical additives mixed into plastics during manufacturing — including stabilizers, flame retardants, and plasticizers — can leach out throughout a plastic's lifecycle and pose risks to ecosystems and human health, with microplastics acting as carriers that concentrate and transport these hazardous chemicals.

2022 TrAC Trends in Analytical Chemistry 194 citations
Article Tier 2

Toward a Framework for Environmental Fate and Exposure Assessment of Polymers

This review discusses challenges and opportunities for developing environmental fate and exposure assessment frameworks for polymers in regulatory risk assessment, finding that the diversity and complexity of polymers requires adaptation of existing chemical assessment approaches.

2021 Environmental Toxicology and Chemistry 23 citations
Article Tier 2

Examination of plastic’s hazards to human health underway

This study examined the multiple health hazards that plastics pose to humans across their entire life cycle, from fossil fuel extraction used as feedstocks through everyday use and disposal, conducting a comprehensive interdisciplinary analysis of exposure pathways and associated health effects.

2022 C&EN Global Enterprise
Article Tier 2

Tackling the toxics in plastics packaging

This review addresses the issue of hazardous chemicals migrating from plastic food packaging into food, including endocrine disrupters, carcinogens, and untested synthetic compounds. The author argues that current toxicity assessment methods for packaging chemicals are inadequate and that plastic packaging is an avoidable source of dietary chemical exposure. The study calls for systemic changes in how food packaging safety is regulated to address both plastic pollution and chemical contamination.

2021 PLoS Biology 80 citations
Article Tier 2

Lehren aus dem Gruppieren von Chemikalien zur Bewertung der Risiken für die Gesundheit des Menschen

This review presents case studies and ten guiding principles for chemical grouping strategies used in human health risk assessment under EU REACH and US TSCA frameworks, arguing that structural similarity alone is insufficient for reliable grouping and that transparent criteria, toxicological similarity, and clearly defined group boundaries are essential for regulatory decision-making.

2022 Angewandte Chemie
Article Tier 2

Prevalence and Impact of Emerging Chemical Contaminants in the Life Style Products on Human Health

This review examines emerging chemical contaminants found in everyday consumer products, including plasticizers, flame retardants, and microplastics, assessing their prevalence and potential health risks from chronic low-level exposure.

2024 Oriental Journal of Physical Sciences
Article Tier 2

Contaminant Classes, Sources, and Pathways in Freshwater Environments

This book chapter reviewed major classes of chemical contaminants in freshwater environments, including microplastics, heavy metals, pharmaceuticals, and pesticides, outlining their sources, transport pathways, and ecological risks. The authors highlight the complexity of freshwater contamination and the challenges of regulation.

2025
Article Tier 2

The time for ambitious action is now: Science-based recommendations for plastic chemicals to inform an effective global plastic treaty.

A broad scientific review made the case for ambitious global action on plastic pollution, cataloguing the more than 16,000 chemicals in plastics — including many known toxins — and their potential to leach into food, water, and the environment. The authors argue that the scale of chemical risk from plastics justifies sweeping regulatory action on both production and chemical content.

2024 The Science of the total environment
Article Tier 2

The widely disregarded health risks posed by phthalates - A global call for action

This review highlights the widespread health risks posed by phthalates from microplastic-containing products, emphasizing their routes of human exposure through food, packaging, and personal care items, and their documented effects including oncogenicity and fetal developmental impacts. The authors call for urgent global regulatory action given the scale and severity of phthalate exposure.

2023 Toxicology in Vitro 3 citations
Article Tier 2

First Steps Toward Sustainable Circular Uses of Chemicals: Advancing the Assessment and Management Paradigm

This article advances a framework for sustainable circular use of chemicals, proposing updated assessment and management approaches to reduce chemical hazards while enabling circularity in industrial and consumer product systems.

2021 ACS Sustainable Chemistry & Engineering 53 citations
Article Tier 2

Pollution Risks, Impacts & Management: Social, Economic and Environmental Perspectives

This edited volume covers pollution risks across multiple contaminant categories including microplastics, heavy metals, pesticides, pharmaceuticals, and algal toxins, examining their chemistry, ecotoxicology, socioeconomic impacts, and management strategies.

2024 Figshare
Article Tier 2

A Review of Paint Pollution and Its Adverse Impact on the Environment and Human Health

This review examines the sources of paint pollution—primarily volatile organic compounds and hazardous substances released during application and drying—and summarizes their health implications, environmental impacts, regulatory frameworks, and mitigation strategies. It does not focus on microplastics specifically but includes paint-derived MP particles as a recognized pollution pathway.

2025 International Journal For Multidisciplinary Research
Article Tier 2

Polymers and Microplastics: Implications on Our Environment and Sustainability

This review discusses the environmental implications of polymers and microplastics, covering their properties, production trends, degradation pathways, and ecological impacts. It highlights the tension between the industrial utility of plastics and their growing threat to environmental and human health.

2020 IntechOpen eBooks 2 citations
Article Tier 2

Emerging Pollutants in the Environment

This introductory chapter defines emerging pollutants as unregulated chemicals of ecological and human health concern, categorizing microplastics, endocrine disruptors, pharmaceuticals, and disinfection byproducts as priority contaminants requiring new monitoring and regulatory frameworks.

2025
Article Tier 2

Nano/micro-plastics: Sources, trophic transfer, toxicity to the animals and humans, regulation, and assessment

This review comprehensively covered the sources, trophic transfer pathways, toxicity to animals and humans, and regulatory status of nano- and microplastics, synthesizing evidence that these particles are broadly distributed and cause harm across multiple biological levels. The authors called for improved global regulatory frameworks given the pace at which exposure evidence is accumulating.

2022 Advances in food and nutrition research 9 citations