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61,005 resultsShowing papers similar to Comparative analysis of reproductive toxicity of polystyrene‐nanoplastics and polystyrene‐microplastics in rat Sertoli cells
ClearToxic Effects of Immunofluorescent Polystyrene Nanoplastics on Rat Testicular Tissue
Researchers exposed rat testicular tissue to fluorescent polystyrene nanoplastics at two different doses for one month and found that the particles accumulated in the reproductive organs. Higher doses led to increased oxidative stress, tissue damage, and changes in biochemical markers associated with reproductive function. The study suggests that nanoplastic exposure may pose risks to male reproductive health, though more research is needed to understand the implications for humans.
Assessment of microplastic toxicity on blood-testis barrier using 3D cell spheroids
Researchers used 3D cell spheroids to model the blood-testis barrier and tested how polystyrene microplastics affect male reproductive tissue. They found that microplastic exposure triggered endoplasmic reticulum stress in Sertoli cells, with effects varying by particle size and concentration. The study suggests that microplastics may pose risks to reproductive health by disrupting the cellular stress response in testicular barrier tissues.
The emerging risk of exposure to nano(micro)plastics on endocrine disturbance and reproductive toxicity: From a hypothetical scenario to a global public health challenge
Researchers administered polystyrene nanoplastics orally to male rats for five weeks and found significant reductions in testosterone, LH, and FSH levels, sperm DNA damage, altered testicular gene expression, and dose-dependent histological lesions, indicating that nanoplastic exposure disrupts the hormonal axis governing male reproductive function.
Unravelling the potential mechanisms of nano- and microplastic toxicity to the male reproductive system: A systematic review
This systematic review found that micro- and nanoplastics accumulate in the testes and epididymis in rodent models, disrupting the blood-testis barrier, increasing germ cell death, reducing sperm motility, and causing hormone imbalance through oxidative stress and inflammation. Smaller nanoplastics penetrate tissues more readily for molecular disruption, while larger microplastics cause greater structural damage.
Dose-Dependent Effect of Polystyrene Microplastics on the Testicular Tissues of the Male Sprague Dawley Rats
Male rats exposed to increasing doses of polystyrene microplastics showed dose-dependent testicular damage including disrupted spermatogenesis and altered hormone levels, suggesting potential reproductive toxicity from microplastic accumulation.
Polystyrene Microplastics Disrupt Spermatogenesis through Oxidative Stress in Rat Testicular Tissue
Male Wistar rats orally administered polystyrene microplastics showed excessive oxidative stress in testicular tissue across all exposure groups, with spermatogenesis impairment and reduced fertility correlating with dose, demonstrating reproductive toxicity in a mammalian model.
In Vitro Nano-Polystyrene Toxicity: Metabolic Dysfunctions and Cytoprotective Responses of Human Spermatozoa
Researchers investigated the effects of polystyrene nanoplastics (50 and 100 nm) on mature human sperm cell metabolism in vitro. The study found that smaller 50 nm particles showed higher toxicity, causing acrosomal damage, oxidative stress, DNA fragmentation, and decreased mitochondrial activity, while 100 nm particles primarily affected the acrosome, suggesting size-dependent impacts of nanoplastics on reproductive cell function.
Polystyrene microplastics induced male reproductive toxicity in mice
Researchers exposed male mice to polystyrene microplastics of different sizes and found that the particles accumulated in testicular tissue and entered reproductive cells. After 28 days of exposure, sperm quality and testosterone levels declined, and tissue examination revealed disorganized sperm-producing cells and inflammation. The study suggests that microplastic exposure may pose risks to male reproductive health in mammals.
Adolescent exposure to polystyrene nanoplastics induces male reproductive damage via the microbiome-gut-testis axis
Researchers exposed adolescent rats to polystyrene nanoplastics for five weeks and observed dose-dependent damage to testicular tissue, disrupted spermatogenesis, and compromised blood-testis barrier integrity. The study revealed a novel microbiome-gut-testis axis mechanism, where nanoplastics altered gut bacteria composition, which in turn contributed to reproductive toxicity in developing males.
Can Mammalian Reproductive Health Withstand Massive Exposure to Polystyrene Micro- and Nanoplastic Derivatives? A Systematic Review
This systematic review examined how polystyrene micro- and nanoplastics affect reproductive health in mammals. The evidence from animal studies shows these particles can cause oxidative stress, inflammation, and hormonal imbalances in reproductive organs, raising concerns about potential effects on human fertility.
Multi-endpoint toxicological assessment of polystyrene nano- and microparticles in different biological models in vitro
Researchers assessed the toxicity and transport of polystyrene nano- and microparticles using multiple human cell models, including intestinal and placental barrier systems. They found that while neither size was acutely toxic, the nanoparticles were able to cross the intestinal barrier and showed some embryotoxic potential. The study suggests that nanoplastics may pose greater health concerns than microplastics due to their ability to penetrate biological barriers.
Effects of micro(nano)plastics on the reproductive system: A review
This review summarizes research on how micro and nanoplastics affect the reproductive system in both animal studies and cell experiments. Evidence indicates these particles can cross biological barriers, accumulate in reproductive organs, and disrupt hormones, egg development, and sperm quality. While human studies are still limited, the animal data suggests microplastic exposure may be a meaningful concern for reproductive health.
The male reproductive toxicity after nanoplastics and microplastics exposure: Sperm quality and changes of different cells in testis
A mouse study compared the reproductive toxicity of nanoplastics versus microplastics and found that both damaged the testes after 12 weeks of exposure, but microplastics caused more severe harm in some measures. The plastics disrupted sperm production, caused inflammation and oxidative stress, and damaged the cells that support sperm development. These findings suggest that plastic particle exposure could contribute to male fertility problems, with different particle sizes affecting reproductive health through different biological pathways.
Reproductive toxicity and related mechanisms of micro(nano)plastics in terrestrial mammals: Review of current evidence.
This review of terrestrial mammal studies found that micro- and nanoplastics induce reproductive toxicity through oxidative stress, inflammation, endocrine disruption, and DNA damage, affecting both male and female fertility. In males, effects include blood-testis barrier disruption and impaired spermatogenesis, while females show compromised oocyte maturation, ovarian fibrosis, and diminished ovarian reserve, with particles also capable of crossing the maternal-fetal interface.
Polystyrene microplastics induce blood-testis barrier disruption regulated by MAPK-Nrf2 signaling pathway in rats
Researchers found that polystyrene microplastics (PS-MPs) disrupted the blood-testis barrier in male rats after 90 days of exposure, with higher doses (0.15 and 1.5 mg/d) causing significant spermatogenic cell apoptosis and reduced sperm motility through activation of the MAPK-Nrf2 signaling pathway.
Oral exposure to polystyrene nanoplastics altered the hypothalamic–pituitary–testicular axis role in hormonal regulation, inducing reproductive toxicity in albino rats
This study found that oral exposure to polystyrene nanoplastics disrupted the hormone signaling pathway between the brain and testes in male rats, leading to reproductive damage. The nanoplastics interfered with the hormones that regulate sperm production and testicular function. These findings add to growing evidence that nanoplastic exposure through food and water could be a contributing factor to declining male fertility.
Polystyrene microplastics induce blood–testis barrier disruption regulated by the MAPK-Nrf2 signaling pathway in rats
Researchers fed rats polystyrene microplastics for 90 days and found significant damage to male reproductive health, including reduced sperm quality, damaged sperm-producing tissue, and increased cell death. The study identified a specific molecular pathway where microplastics triggered oxidative stress that disrupted the blood-testis barrier, a critical protective structure in the testes. These findings provide new evidence that microplastic exposure may pose risks to male reproductive function.
Impact of polystyrene microplastic exposure on lipid profile and oxidative stress status of male and female Wistar rats
Researchers found that polystyrene microplastic exposure in Wistar rats caused significant alterations in lipid profiles and increased oxidative stress markers, with effects varying between male and female rats and between pristine polystyrene and Styrofoam forms.
Polystyrene nanoplastics aggravate reproductive system damage in obese male mice by perturbation of the testis redox homeostasis
Researchers found that polystyrene nanoplastics worsened reproductive damage in male mice already fed a high-fat diet, reducing sperm quality and testosterone production beyond what obesity alone caused. The nanoplastics disrupted the protective blood-testis barrier and increased oxidative stress in reproductive tissues. The study suggests that nanoplastic exposure combined with obesity may create compounding risks to male fertility.
DistinctEffects between Polystyrene Micro- and Nanoplastics:Exacerbation of Adverse Outcomes in Inflammatory Bowel Disease-likeZebrafish and Mice
Researchers compared the effects of polystyrene micro- and nanoplastics on a biological system, finding that nanoplastics caused more severe adverse effects than microplastics at equivalent mass doses, likely due to greater surface area and cellular penetration capacity.
Research Progress in Reproductive Toxicity of Micro- and Nanoplastics on Males and Its Mechanisms
This review summarized research on the reproductive toxicity of micro- and nanoplastics (MNPs) in males, finding that MNPs accumulate in reproductive organs and cause toxicity through oxidative stress, hormonal disruption, and DNA damage, with implications for both animal and human reproductive health.
Impact of polystyrene microplastic exposure at low doses on male fertility: an experimental study in rats
Researchers exposed adult male rats to varying doses of polystyrene microplastics and found dose-dependent declines in semen quality along with disrupted reproductive hormone levels. Higher doses caused increased oxidative stress, mitochondrial damage, and inflammatory responses in testicular tissue. The study suggests that even relatively low doses of microplastic exposure may have adverse effects on male reproductive health in animal models.
Investigation of potential toxic effects of nano- and microplastics on human endometrial stromal cells
Researchers exposed human endometrial cells (uterine lining cells) to polystyrene nano- and microplastics and found that smaller particles (100 nanometers) were taken up most readily, accumulating in both the nucleus and cytoplasm. At higher concentrations, the nanoplastics reduced cell growth and triggered cell death. These findings suggest that nanoplastics could pose a risk to uterine health and potentially affect fertility and pregnancy outcomes.
Examining the Relationship Between Polystyrene Microplastics and Male Fertility: Insights From an In Vivo Study and In Vitro Sertoli Cell Culture
This study found that polystyrene microplastics caused reproductive damage in male mice, disrupting the cells that support sperm development (Sertoli cells). The microplastics interfered with normal reproductive function in both live mice and cell cultures. These findings add to growing evidence that microplastic exposure could contribute to declining male fertility, a trend already observed in humans worldwide.