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Papers
20 resultsShowing papers similar to Integrating multi-omics and network toxicology to identify FIS1 as a key target of environmental pollutants in male infertility
ClearAnalyzing the toxicological effects of PET-MPs on male infertility: Insights from network toxicology, mendelian randomization, and transcriptomics
Using network toxicology, Mendelian randomisation, and transcriptomic analysis, researchers identified mechanisms by which PET microplastics may impair male fertility, linking shared gene targets to testicular oxidative stress, hormonal disruption, and spermatogenesis interference. The multi-evidence approach strengthens the case for a causal role of PET-MP exposure in male infertility.
Quantitative analysis and toxicological mechanisms of various male infertility inducers: A network meta-analysis and pharmacological approach.
This network meta-analysis of 201 rodent studies compared nine common male infertility inducers, finding that microplastics caused among the most severe impairments to sperm count and motility — on par with the chemotherapy drug cyclophosphamide. Oxidative stress emerged as a shared mechanistic pathway across all inducers, pointing to it as a key target for understanding and potentially mitigating reproductive harm from environmental exposures.
Environmental determinants of male infertility: emerging threats and technological interventions
This review examines how environmental contaminants, including microplastics, air pollution, heavy metals, and endocrine-disrupting chemicals, may contribute to declining male fertility. The study suggests these environmental toxins can impair sperm function through oxidative stress, hormonal imbalance, and inflammation, and highlights the need for integrating environmental exposure data into fertility assessments.
The role of environmental toxins in infertility: Insights from cutting-edge research
Researchers reviewed the effects of environmental toxins including bisphenol A, pesticides, heavy metals, microplastics, and electromagnetic fields on human fertility. The study found that these substances have been linked to both male and female infertility through various mechanisms, and highlights the need for greater awareness and regulatory action to reduce exposure to these reproductive toxicants.
A meta-analysis-based adverse outcome pathway for the male reproductive toxicity induced by microplastics and nanoplastics in mammals
This meta-analysis of 39 studies mapped the adverse outcome pathway for microplastic and nanoplastic-induced male reproductive toxicity in mammals. Increased reactive oxygen species triggers a cascade of cellular damage including mitochondrial dysfunction, sperm DNA damage, and disrupted hormone signaling, ultimately leading to reduced sperm quality, impaired spermatogenesis, and decreased testosterone levels.
Mechanistic insight into the protective effects of fisetin against arsenic-induced reproductive toxicity in male rats
Researchers showed that arsenic — a heavy metal contaminant found alongside plastic pollution in many environments — severely damages sperm quality and hormone levels in male rats, and that the plant compound fisetin significantly reversed this damage. The results suggest fisetin may help protect male reproductive health from toxic environmental exposures.
Microplastics: unraveling the signaling pathways involved in reproductive health
This review examines the effects of microplastics on male and female reproductive health, focusing on the metabolic pathways involved in compromised gamete quality, toxicity, apoptosis, and DNA damage. Evidence indicates that microplastics can increase oxidative stress leading to developmental abnormalities, epigenetic changes, and reduced gamete quality, though research on mammalian and human reproductive effects remains limited compared to studies in aquatic organisms.
The Threat of Micro-/Nanoplastics to Male Fertility: A Review of the Data and the Importance of Future Research
This review synthesizes findings from 21 studies examining how micro- and nanoplastics and their associated endocrine-disrupting chemicals affect male reproductive health at the cellular level. Researchers found evidence of multiple toxicity mechanisms including damage to the blood-testis barrier, disruption of hormone signaling, oxidative stress, and structural damage to testicular tissues. The study notes that while these findings from cell and animal studies are concerning, translating the results to human health requires further research with realistic exposure conditions.
Multi-mechanistic effects of bisphenol A on testicular dysfunction and endocrine disruption in adult male Labeo bata: oxidative stress, inflammation, and dysregulated energy sensors
Researchers studied how bisphenol A (BPA), a chemical that leaches from microplastics in water, affects reproductive function in male fish. They found that chronic BPA exposure at environmentally relevant concentrations caused significant testicular damage, including reduced sperm production, increased inflammation, and disrupted hormone signaling. The study reveals multiple mechanisms by which this common microplastic-associated chemical can impair male reproductive health in aquatic species.
Impacto de los disruptores endocrinos derivados de plásticos en la regulación hormonal masculina: un análisis integral de la evidencia científica
This literature review compiled recent studies on how phthalates, bisphenol A, and microplastics from plastic products disrupt male hormonal regulation, finding evidence for reduced testosterone, impaired testicular synthesis, and alterations in the hypothalamic-pituitary-gonadal axis. The review calls for greater attention to plastic-derived endocrine disruptors in male reproductive health research.
Impact of environmental toxin exposure on male fertility potential
This review examines how environmental toxin exposures, including endocrine-disrupting chemicals found in plastics, may contribute to declining male fertility. Researchers found consistent evidence linking exposure to phthalates, bisphenol A, and other synthetic chemicals to reduced sperm quality and hormonal disruption. The study suggests that the dramatic increase in human chemical exposures over recent decades may be a significant factor in the observed decline in male reproductive health.
Effects and risk assessment of halogenated bisphenol A derivatives on human follicle stimulating hormone receptor: An interdisciplinary study
Researchers found that halogenated derivatives of bisphenol A (BPA) — chemicals produced during water disinfection or used as flame retardants — can bind to and suppress a key reproductive hormone receptor (FSHR) at concentrations as low as 10 nanomolar. Comparing lab results with real-world human urine data suggests people may already be exposed to levels that could interfere with normal reproductive hormone signaling.
Environmental and microbiome determinants of sperm quality: a narrative review on male health
This narrative review examines how environmental factors, including microplastics and other emerging contaminants, affect male sperm quality and fertility. The study suggests that pollutants such as heavy metals, pesticides, phthalates, PFAS, air pollution, and microplastics can impair sperm parameters through various mechanisms, and highlights the role of the reproductive microbiome in mediating these environmental effects.
Human risk associated with exposure to mixtures of antiandrogenic chemicals evaluated using in vitro hazard and human biomonitoring data
Researchers evaluated the combined health risk of exposure to multiple hormone-disrupting (antiandrogenic) chemicals using both lab test data and human biomonitoring measurements. Their analysis suggests that boys with high cumulative exposure to these chemicals face a potential concern for harm to reproductive function, highlighting the need to assess chemical mixtures rather than individual substances in isolation.
Leveraging integrative toxicogenomic approach towards development of stressor-centric adverse outcome pathway networks for plastic additives
Researchers applied integrative toxicogenomics to develop adverse outcome pathway networks for plastic additives that leach into the environment during plastic degradation. The study suggests that this approach can help systematically assess the health risks of chemical additives released from plastics across atmospheric, terrestrial, and aquatic ecosystems.
Fetal exposure to endocrine disrupting-bisphenol A (BPA) alters testicular fatty acid metabolism in the adult offspring: relevance to sperm maturation and quality
This study showed that prenatal exposure to bisphenol A in rats altered testicular fatty acid metabolism in adult male offspring, reducing levels of polyunsaturated fatty acids essential for sperm quality and function, linking early BPA exposure to lasting male reproductive effects.
Microplastics and male reproductive system: A comprehensive review based on cellular and molecular effects
This comprehensive review examines how microplastics affect the male reproductive system at cellular and molecular levels, drawing on studies from multiple scientific databases. Researchers found that microplastics can damage testicular structure and function, impair spermatogenesis, and disrupt sperm parameters through mechanisms including oxidative stress, inflammation, and activation of cell death pathways. The review highlights that microplastics reduce ATP production and trigger signaling cascades that may contribute to male fertility problems.
An Integrated Metabolomics-Based Model, and Identification of Potential Biomarkers, of Perfluorooctane Sulfonic Acid Toxicity in Zebrafish Embryos
Researchers used advanced metabolomics techniques to study how the industrial chemical PFOS affects zebrafish embryo development at the molecular level. They identified specific metabolic disruptions and potential biomarkers that could indicate early PFOS exposure. The study provides new insights into how persistent environmental pollutants like PFAS interfere with biological processes during critical developmental stages.
A computational framework for multi-scale data fusion in assessing the associations between micro- and nanoplastics and human hepatotoxicity
Researchers developed a computational toxicology framework integrating multi-source data and network analysis to map associations between micro- and nanoplastics and hepatotoxicity, identifying key molecular pathways through which MNPs may damage the liver, offering a scalable alternative to traditional in vivo testing.
Interplay of Ferroptosis, Cuproptosis, Autophagy and Pyroptosis in Male Infertility: Molecular Crossroads and Therapeutic Opportunities
This review examines how different types of cell death, including ferroptosis, cuproptosis, pyroptosis, and autophagy, contribute to male infertility by damaging sperm-producing cells. Environmental toxins, including microplastics, can trigger these destructive pathways through oxidative stress and mitochondrial damage. Understanding these mechanisms is important because it helps explain how environmental pollutant exposure could be contributing to declining male fertility worldwide.