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Human risk associated with exposure to mixtures of antiandrogenic chemicals evaluated using in vitro hazard and human biomonitoring data
Summary
Researchers evaluated the combined health risk of exposure to multiple hormone-disrupting (antiandrogenic) chemicals using both lab test data and human biomonitoring measurements. Their analysis suggests that boys with high cumulative exposure to these chemicals face a potential concern for harm to reproductive function, highlighting the need to assess chemical mixtures rather than individual substances in isolation.
This viable way forward for mixture risk assessment of chemicals has the advantages of (1) being a more comprehensive mixture risk assessment also covering data-poor chemicals, and (2) including human data only. However, the approach is subjected to uncertainties in terms of in vitro to in vivo extrapolation, it is not ready for decision making, and needs further development. Still, the results indicate a concern for adverse effects on reproductive function in highly exposed boys, especially when considering additional exposure to data-poor chemicals and chemicals acting by other mechanisms of action.
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