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61,005 resultsShowing papers similar to Protective Effect of Paeoniae Radix Alba Carbonisata on Hepatic Amyloidosis by Regulating Calcium Homeostasis
ClearJianwei Xiaoshi oral liquid attenuates high-calorie diet-induced dyspepsia in immature rats via regulating the pancreatic secretion pathway and maintaining the homeostasis of intestinal microbiota
Researchers found that a traditional Chinese herbal medicine formula called Jianwei Xiaoshi oral liquid improved functional digestive problems in young rats fed a high-calorie diet by regulating eight key proteins involved in pancreatic digestion and restoring healthy gut bacteria balance. The findings suggest potential therapeutic benefits of this herbal remedy for diet-induced digestive disorders in children.
Preparation of Polysaccharides from Qifuyin and Investigation of Their Anti-Oxidant and Regenerative Effects Based on Planaria
Researchers extracted polysaccharides from the traditional Chinese medicine formula Qifuyin using hydrothermal methods, achieving 29.9% yield and 70.1% purity, and investigated their antioxidant and regenerative effects using planaria as a model organism.
Inhibitory Effects of Jiuzao Polysaccharides on Alcoholic Fatty Liver Formation in Zebrafish Larvae and Their Regulatory Impact on Intestinal Microbiota
Researchers investigated the protective effects of Laowuzeng Jiuzao polysaccharides on ethanol-induced alcoholic fatty liver in zebrafish larvae, finding that the polysaccharides reduced hepatic damage and regulated intestinal microbiota composition, suggesting therapeutic potential for alcohol-related liver disease.
Hepatoprotective Effect of Allium ochotense Extracts on Chronic Alcohol-Induced Fatty Liver and Hepatic Inflammation in C57BL/6 Mice
Researchers tested extracts from the plant Allium ochotense for their ability to protect against alcohol-induced liver damage in mice. The study found that the extracts improved lipid metabolism, reduced liver inflammation, and boosted antioxidant defenses, suggesting potential as a natural approach to supporting liver health in the context of chronic alcohol consumption.
Beneficial effect of Xuebijing against Pseudomonas aeruginosa infection in Caenorhabditis elegans
Researchers found that the traditional Chinese medicine formulation Xuebijing protected Caenorhabditis elegans against Pseudomonas aeruginosa infection by enhancing immune pathways and reducing bacterial colonization, providing mechanistic insight into its clinical use for treating sepsis.
The Impact of Microalgae and Their Bioactive Compounds on Liver Well-being in Rats Subjected to Synthetic Phenolic Antioxidants
This review examines how microalgae and their bioactive compounds — including polysaccharides, pigments, and polyphenols — protect liver health in animal models, summarizing evidence for anti-inflammatory and antioxidant mechanisms. The authors note that algal-derived compounds show hepatoprotective effects in rodent studies, though human clinical evidence remains limited.
Genotoxicity Assessment of Hwanglyeonhaedok-Tang: An Herbal Formula Evaluated Using the In Vivo Alkaline Comet Assay and Pig-a Gene Mutation Assay in Rats
Researchers tested whether the traditional Asian herbal formula Hwanglyeonhaedok-tang caused DNA damage in rats using in vivo comet and Pig-a gene mutation assays, following earlier positive in vitro genotoxicity results. The in vivo assays did not confirm genotoxicity, suggesting the previous signals may be false positives under realistic dosing conditions.
Ethanol Extract of Rosa rugosa Ameliorates Acetaminophen-Induced Liver Injury via Upregulating Sirt1 and Subsequent Potentiation of LKB1/AMPK/Nrf2 Cascade in Hepatocytes
Researchers prepared an ethanol extract from Rosa rugosa flower buds and found it significantly reduced liver damage caused by acetaminophen overdose in both cell and mouse models. The extract worked by activating the Sirt1 protein and boosting a protective signaling pathway that counters oxidative stress in liver cells. The study suggests Rosa rugosa extract may have potential as a natural intervention for drug-induced liver injury.
Renoprotective Effect of Chrysanthemum coronarium L. Extract on Adenine-Induced Chronic Kidney Disease in Mice
Researchers investigated the renoprotective effects of Chrysanthemum coronarium extract on adenine-induced chronic kidney disease in mice, finding it reduced inflammation and fibrosis markers associated with progressive loss of renal function.
Toxicity of AgNPs upon Liver Function and Positive Role of Tinospora Cordifolia: In Vivo
Researchers found that silver nanoparticle exposure caused significant liver toxicity in male rats, and that Tinospora cordifolia extract provided a protective effect by mitigating the nanoparticle-induced disruption of liver function parameters.
The potential mechanism of huazhuojiedu decoction in the treatment of ulcerative colitis based on network pharmacology and experimental validation
Researchers used network pharmacology to identify 119 active components and 146 potential targets of the traditional Chinese medicine formula Huazhuojiedu decoction relevant to ulcerative colitis, then validated key predicted mechanisms in dextran sulfate sodium-induced rat colitis models, elucidating multi-target pathways underlying the formula's clinically observed therapeutic effects.
Protective Effect of Astragaloside IV against Cadmium-Induced Damage on Mouse Renal Podocytes (MPC5)
This paper is not about microplastics; it investigates how the plant compound Astragaloside IV protects kidney cells from cadmium-induced damage, examining mitochondrial and autophagy pathways.
Potential application of traditional Chinese medicine in cerebral ischemia—Focusing on ferroptosis
This review examined evidence for traditional Chinese medicine compounds in treating cerebral ischemia by targeting ferroptosis, an iron-dependent form of regulated cell death. Multiple TCM-derived compounds including flavonoids and alkaloids showed neuroprotective effects through ferroptosis pathway inhibition in experimental ischemia models.
[Screening of quality markers and activity verification of Glycyrrhizae Radix et Rhizoma based on small molecule compound-protein interaction].
Researchers screened 27 chemical compounds in licorice root (Glycyrrhizae Radix) to identify quality markers by measuring how strongly each compound binds to mouse organ proteins. Seven active components were identified, and their anti-inflammatory and antioxidant properties were confirmed in a cell model where macrophages were stressed using microplastics.
Assessment of the protective and ameliorative impact of quercetin nanoparticles against neuronal damage induced in the hippocampus by acrolein
Researchers found that quercetin nanoparticles — tiny particles of a natural antioxidant found in plants — protected brain cells in the hippocampus from damage caused by acrolein, a toxic compound linked to Alzheimer's disease, suggesting nanoparticle delivery of quercetin as a potential therapeutic strategy.
Nanoplastic-Induced Liver Damage Was Alleviated by Maltol via Enhancing Autophagic Flow: An In Vivo and In Vitro Study
Researchers found that nanoplastic exposure caused liver damage in mice through oxidative stress, cell death, and impaired cellular recycling processes. They then tested maltol, a compound derived from red ginseng, and found it significantly reduced the liver damage by restoring healthy autophagy and reducing oxidative stress. The study suggests that natural compounds like maltol could potentially help protect the liver from the harmful effects of nanoplastic accumulation.
Therapeutic Role of Leaf Pulp of Carpobrotus edulis on Chromium VI Induced Toxicity in Wistar Rats
This study tested whether a leaf extract from Carpobrotus edulis (a succulent plant) could protect rats from toxicity caused by hexavalent chromium, a heavy metal contaminant. The extract showed protective effects against chromium-induced organ damage. This paper focuses on herbal remedies for heavy metal toxicity rather than microplastics.
Pharmacodynamic Material Basis and Potential Mechanism Study of Spatholobi Caulis in Reversing Osteoporosis
Researchers investigated the pharmacological mechanisms of Spatholobi Caulis (SC) in reversing osteoporosis, finding it operates through multi-component, multi-target pathways with the AGE-RAGE signaling pathway identified as the primary regulatory mechanism.
Protective effects of herbacetin against polystyrene microplastics-instigated liver damage in rats
Researchers investigated the protective effects of herbacetin, a natural flavonoid, against liver damage caused by polystyrene microplastic exposure in rats. The study found that herbacetin helped restore antioxidant enzyme levels and reduce inflammation markers, suggesting it may offer some protection against microplastic-associated oxidative stress in liver tissue.
Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of Bushen Huashi decoction against kidney stones
This study used network pharmacology and laboratory validation to reveal that a traditional Chinese herbal formula (Bushen Huashi decoction) combats kidney stones by modulating estrogen receptor, NRF2/HO-1 antioxidant, and apoptosis signaling pathways.
Dimethyl Bisphenolate Ameliorates Carbon Tetrachloride-Induced Liver Injury by Regulating Oxidative Stress-Related Genes
Researchers synthesized a novel compound called dimethyl bisphenolate and tested its ability to protect against chemically induced liver injury in rats and cell models. They found that the compound significantly reduced liver damage markers and oxidative stress in a dose-dependent manner, with effects comparable to the established liver protectant silymarin. The study suggests that dimethyl bisphenolate may help protect liver cells by regulating oxidative stress pathways and reducing cell death.
The Traditional Chinese Medicine in Treating Diabetic Nephropathy: A Bibliometric Analysis
This bibliometric analysis reviews research trends on Traditional Chinese Medicine for treating diabetic nephropathy. The study identifies key research hotspots including the clinical efficacy of herbal treatments and their pharmacological mechanisms, with improving oxidative stress and regulating gut microbiota highlighted as promising directions for future investigation.
Black Lycium barbarum polysaccharide attenuates LPS-induced intestine damage via regulation gut microbiota
Researchers studied whether a polysaccharide from black Lycium barbarum could protect against intestinal damage caused by bacterial toxins in mice. They found that the supplement alleviated intestinal tissue damage and improved gut microbiota diversity by promoting beneficial bacteria. The study suggests that this plant-derived polysaccharide may help maintain intestinal health by modulating the gut microbial community.
Dietary silymarin, Silybum marianum extract ameliorates cadmium chloride toxicity in common carp, Cyprinus carpio
Supplementing the diet of common carp with silymarin extract protected fish from cadmium chloride toxicity, with treated fish showing reduced liver damage, lower oxidative stress markers, and better growth performance compared to cadmium-exposed controls without the supplement.