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Papers
61,005 resultsShowing papers similar to Enhanced Anti-Tumor Activity in Mice with Temozolomide-Resistant Human Glioblastoma Cell Line-Derived Xenograft Using SN-38-Incorporated Polymeric Microparticle.
ClearNanomaterials in Drug Delivery: Strengths and Opportunities in Medicine
This review covers how nanomaterials are being used to improve drug delivery for treating cancer and infections, offering better targeted therapy with fewer side effects. While not directly about microplastics, the research on how nanoparticles interact with human tissues provides insight into how similarly sized nanoplastics might behave once inside the body.
A Self-Cascade Penetrating Brain Tumor Immunotherapy Mediated by Near-Infrared II Cell Membrane-Disrupting Nanoflakes via Detained Dendritic Cells
This study developed nanoparticle-based technology to treat aggressive brain tumors (glioblastoma) by penetrating deep into tumor tissue and activating the immune system against cancer cells. While not directly about microplastic pollution, it demonstrates that nanoparticles can cross brain barriers and influence immune responses. The research is relevant because it shows how tiny particles, including plastics, can access and affect the brain.
Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance
This review explores how nanotechnology is being used to overcome drug resistance in cancer treatment, using materials like carbon nanotubes, dendrimers, and liposomes to deliver drugs more precisely to tumors. While not directly about microplastics, the nanomaterial strategies discussed share relevance with understanding how nano-sized plastic particles interact with human cells and tissues.
Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment
This review covers advances in targeted drug delivery using nanotechnology, including nanoparticles and liposomes designed to release medications precisely where needed in the body. While focused on cancer treatment, the drug delivery technologies discussed are relevant to understanding how nanoscale plastic particles may also travel through the body and accumulate in specific tissues.
Polyethylene Glycol-Based Polymer-Drug Conjugates: Novel Design and Synthesis Strategies for Enhanced Therapeutic Efficacy and Targeted Drug Delivery
This paper is not about microplastics — it reviews the design and synthesis of polyethylene glycol (PEG)-based polymer-drug conjugates as targeted drug delivery systems for cancer and other diseases, with no relevance to microplastic pollution or environmental health.
Effect of paclitaxel octreotide conjugate on human ovarian paclitaxel-resistant cell xenograft tumor model and the mechanism underlying reversal of paclitaxel resistance
This paper is not relevant to microplastics — it examines the efficacy of a paclitaxel-octreotide conjugate for overcoming drug resistance in human ovarian cancer cell xenograft models.
Genotoxic and neurotoxic potential of intracellular nanoplastics: A review
This review examines how nanoplastics, once inside human cells, could cause cancer and brain damage. At the cellular level, these tiny particles can disrupt waste-clearing processes, damage mitochondria, generate harmful free radicals, and directly damage DNA. In long-lived cells like neurons, nanoplastics may promote the buildup of toxic protein clumps linked to neurodegenerative diseases, while in rapidly dividing cells they could trigger tumor development.
Biodegradable Nanoplastic: a Tool for Drug Delivery and Environmental Challenge
This review discusses the dual nature of biodegradable nanoplastics — their promise as targeted drug delivery vehicles due to their controllable surface chemistry, versus the environmental concern of uncontrolled nanoplastic accumulation from biodegradable polymer degradation in ecosystems.
Insights into Healthcare Professionals’ Perceptions and Attitudes toward Nanotechnological Device Application: What Is the Current Situation in Glioblastoma Research?
This paper is not about microplastics; it is an exploratory review of healthcare professionals' perceptions and attitudes toward nanotechnological devices in glioblastoma cancer treatment.
Chitosan-Polycaprolactone Core-Shell Microparticles for Sustained Delivery of Bevacizumab.
This study developed biodegradable chitosan-polycaprolactone microparticles for extended release of an anti-cancer drug into the eye, achieving sustained drug delivery over several months. This is a pharmaceutical drug delivery study using 'microparticles' to describe engineered carriers and is not related to environmental plastic pollution.
Novel application of microparticles demonstrate myeloid uptake and induce phenotypic change within the brain tumor microenvironment 2254
Researchers demonstrated that microparticles can be taken up by myeloid cells within glioblastoma tumors and can induce phenotypic changes in tumor-associated macrophages and neutrophils, suggesting that particle-based approaches may be able to modify the immunosuppressive tumor microenvironment.
Evidence on Invasion of Blood, Adipose Tissues, Nervous System and Reproductive System of Mice After a Single Oral Exposure: Nanoplastics versus Microplastics.
Researchers found that after a single oral exposure in mice, nanoplastics were rapidly absorbed into the blood, accumulated in fat tissues, and crossed both the blood-brain and blood-testis barriers. The study demonstrated that the distribution and behavior of plastic particles in mammals is strongly dependent on particle size, with nanoplastics showing substantially greater tissue penetration than microplastics.
Exploring Metal Nanoparticles Interaction with Cancer Cells
This paper is not relevant to microplastics research — it reviews the uses of metal nanoparticles in biomedical applications, particularly cancer treatment, and discusses their toxicity profiles.
An updated systematic review about various effects of microplastics on cancer: A pharmacological and in-silico based analysis
This systematic review with in-silico analysis found that microplastics have both tumor-promoting and tumor-suppressing effects on cancer cells, affecting viability, migration, metastasis, and apoptosis. The study identified key proteins (AP2M1, ASGR2, BI-1, Ferritin Heavy Chain) involved in microplastic-mediated cancer progression and used computational modeling to identify existing drugs that might counteract these pathways.
From Bottles to Brains: The Role of Microplastics in Enhancing Brain Cancer Cell Growth
Researchers found that low concentrations of microplastics may promote brain cancer cell growth in laboratory experiments, while very high concentrations became toxic to the cells. The study highlights concerns about microplastics crossing the blood-brain barrier and interacting with human cells, though the findings are preliminary lab-based results.
The Other Side of Plastics: Bioplastic-Based Nanoparticles for Drug Delivery Systems in the Brain
This review explores bioplastic-based nanoparticles as potential drug delivery vehicles for brain diseases, examining both their therapeutic promise and safety concerns. Researchers found that biodegradable polymers can pass through biological barriers and concentrate in specific tissues, making them useful for targeted drug delivery. However, the study cautions that the same properties enabling tissue penetration also raise concerns about long-term accumulation and unknown biological effects.
The micro(nano)plastics perspective: exploring cancer development and therapy
This review explores the emerging link between microplastics and cancer development. Microplastics can trigger chronic inflammation, oxidative stress, and hormone disruption, all of which are known pathways that may promote cancer growth. Interestingly, researchers are also studying whether engineered microplastics could be used as drug carriers for cancer therapy, though long-term effects remain unclear.
Hydrogel-based nanoparticles: revolutionizing brain tumor treatment and paving the way for future innovations
Researchers reviewed how nanoparticles embedded in hydrogels — water-based gel materials — can serve as targeted drug delivery vehicles for brain tumors by crossing the blood-brain barrier, a major obstacle that blocks most medications from reaching the brain. These systems have shown improved survival rates in studies, and the review outlines remaining challenges around manufacturing, stability, and scaling up for clinical use.
Unveiling the toxicity of micro-nanoplastics: A systematic exploration of understanding environmental and health implications
This review summarizes what is known about the toxicity of micro- and nanoplastics, noting they can cross critical barriers in the body including the blood-brain barrier. Studies in lab animals show these particles can cause DNA damage, oxidative stress, and cell death, with potential effects on the brain, heart, lungs, and skin, underscoring the need for more real-world human studies.
Effects of microplastics on chemo-resistance and tumorigenesis of colorectal cancer
For the first time, researchers confirmed the presence of microplastics in human colorectal cancer tissue and showed in animal models that microplastics increased cancer rates and made tumors more resistant to chemotherapy drugs. The study found that microplastics trigger a cell survival mechanism called autophagy that helps cancer cells resist treatment, suggesting plastic pollution could complicate cancer outcomes.
Microplastics and Nanoplastics in Cancer Progression: Biology and Public Health
This review examines emerging evidence that microplastics and nanoplastics may contribute to cancer-related processes by crossing biological barriers and accumulating in tissues. The study highlights that these particles can cause oxidative stress, inflammation, DNA damage, and barrier dysfunction at the cellular level, and may promote tumor-supporting processes including angiogenesis and immune evasion.
Role of microplastics in the tumor microenvironment (Review)
This review examines how microplastics may help tumors grow by influencing the environment around cancer cells. Microplastics can interact with immune cells, connective tissue cells, blood vessel cells, and the tissue scaffolding around tumors in ways that may promote cancer progression and inflammation. While more research is needed, the findings raise important questions about whether chronic microplastic exposure could affect cancer development in humans.
Deciphering the Neurotoxic Burden of Micro- and Nanoplastics: From Multi-model Experimental Evidence to Therapeutic Innovation
This review summarizes research on how micro- and nanoplastics damage the brain and nervous system, covering evidence from cell studies, animal experiments, and clinical observations. Plastic particles can cross the blood-brain barrier, disrupt the gut-brain connection, cause oxidative stress, and trigger inflammation that leads to memory problems and cognitive decline. The review also discusses potential treatment strategies, making it a useful resource for understanding the brain health risks of plastic exposure.
Neurotoxic effects of polystyrene nanoplastics on memory and microglial activation: Insights from in vivo and in vitro studies
In a mouse study, tiny nanoplastics (30-50 nanometers) that were swallowed reached the brain and caused memory problems by activating the brain's immune cells, called microglia, which triggered inflammation. This is concerning because it shows that nanoplastics small enough to be found in everyday products like cosmetics could cross into the brain and impair cognitive function.