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An updated systematic review about various effects of microplastics on cancer: A pharmacological and in-silico based analysis
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This systematic review with in-silico analysis found that microplastics have both tumor-promoting and tumor-suppressing effects on cancer cells, affecting viability, migration, metastasis, and apoptosis. The study identified key proteins (AP2M1, ASGR2, BI-1, Ferritin Heavy Chain) involved in microplastic-mediated cancer progression and used computational modeling to identify existing drugs that might counteract these pathways.
Microplastics (MPs) are known as substantial environmental and health threats because of their pervasive existence and potential function in human diseases. This study is the first research in which a comprehensive analysis of various impacts of MPs on cancer cells is performed through pharmacological and in silico approaches. Moreover, our results demonstrate that MPs have both promotive and suppressive impacts on cancer cells, changing some of the important features of these kinds of cells including cellular viability, migration, metastasis, and apoptosis. Furthermore, the present study displayed that AP-2 complex subunit mu-1 (AP2M1), Asialoglycoprotein receptor 2 (ASGR2), Bax inhibitor-1 (BI-1), and Ferritin Heavy Chain, and pivotal role in the progression of cancers mediated by MPs. Moreover, our in-silico analysis identified Goserelin, Paclitaxel, Raloxifene, Exemestane, Epirubicin, Trametinib, Vemurafenib, Pactitaxel, and Sorafenib as potential anticancer agents for curing MPS-based cancer. Besides, our results demonstrated that MPs can exacerbate the development of tumor cells by affecting some important mechanisms including oxidative stress, immune suppression, and adjusting of critical signaling pathways. Interestingly, some sorts of MPs also displayed suppressive effects on cancer cells in some particular contexts, highlighting their complicated biological roles in different biological interactions. Ultimately the present survey tries to demonstrate the crucial roles of MPs in cancer cells and the different mechanisms that occur in the mentioned cells in order to emphasize performing more studies about clarifying the roles of MPs in carcinogenesis.
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In-silico pharmacological insights into the therapeutic potential of microRNAs for microplastic-associated cancers
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Researchers systematically screened published literature to identify cancer-related genes altered by microplastic exposure, then computationally evaluated microRNAs with anticancer activity that could target those genes, finding potential miRNA-based therapeutic candidates across breast, gastric, and other microplastic-associated tumor types.
From exposure to oncogenesis: a review on the multifaceted roles of microplastics in tumor initiation and progression
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This review examined the evidence linking microplastic exposure to tumor initiation and progression, covering physical, chemical, and inflammatory mechanisms by which MPs may promote oncogenesis. The authors conclude that while current evidence is largely preclinical, accumulating data warrant serious concern about microplastics as environmental carcinogens.
Table 1_In-silico pharmacological insights into the therapeutic potential of microRNAs for microplastic-associated cancers.docx
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Researchers systematically screened published literature to identify cancer-related genes altered by microplastic exposure, then computationally evaluated microRNAs with anticancer activity that could target those genes, finding potential miRNA-based therapeutic candidates across breast, gastric, and other microplastic-associated tumor types.
Microplastics and Cancer: A Comprehensive Review of Their Impact on Tumor Progression and Mechanisms of Carcinogenesis
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This comprehensive review examines the growing body of evidence linking microplastic exposure to various types of cancer, including colorectal, lung, liver, and breast cancers. Researchers found that microplastics and nanoplastics may promote tumor progression through mechanisms including oxidative stress, chronic inflammation, and disruption of cellular signaling pathways. While the evidence is still emerging, the study highlights the need for further research into the potential cancer-related risks of widespread microplastic exposure.
Role of microplastics in the tumor microenvironment (Review)
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This review examines how microplastics may help tumors grow by influencing the environment around cancer cells. Microplastics can interact with immune cells, connective tissue cells, blood vessel cells, and the tissue scaffolding around tumors in ways that may promote cancer progression and inflammation. While more research is needed, the findings raise important questions about whether chronic microplastic exposure could affect cancer development in humans.
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