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61,005 resultsShowing papers similar to Overview of the hazardous impacts of metabolism-disrupting chemicals on the progression of fatty liver diseases.
ClearThe nexus of environmental endocrine-disrupting chemical exposure and metabolic dysfunction-associated steatotic liver disease: An emerging public health challenge
This review examines evidence that chronic low-dose exposure to endocrine-disrupting chemicals, including micro- and nanoplastics, may be an underappreciated factor driving the global rise of metabolic liver disease. Researchers found that these pollutants can promote liver fat accumulation, inflammation, and scarring by disrupting hormone signaling, gut health, and mitochondrial function. The study suggests that environmental chemical exposures should be considered alongside diet and lifestyle when assessing liver disease risk.
Microplastics in metabolic dysfunction-associated steatotic liver disease: An emerging threat to liver health
This review examined emerging evidence linking microplastic exposure to the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD). The authors found that microplastics detected in liver tissue can exacerbate hepatic inflammation, lipid accumulation, and oxidative stress through multiple mechanisms, adding a novel environmental risk factor to MASLD pathogenesis.
Chronic Nanoplastic Exposure Promotes the Development and Progression of Metabolic Dysfunction‐Associated Steatotic Liver Disease
This study found that chronic exposure to nanoplastics promotes the development and worsening of metabolic dysfunction-associated steatotic liver disease (formerly known as fatty liver disease). Nanoplastics appear to increase vulnerability to liver disease progression. The finding is concerning because fatty liver disease is already widespread, and everyday nanoplastic exposure through food and water could be making it worse.
Plastic compounds and liver diseases: Whether bisphenol A is the only culprit
This review looks at how plastic-derived chemicals beyond just bisphenol A (BPA) can damage the liver, particularly by contributing to non-alcoholic fatty liver disease (NAFLD). The authors find that microplastics, nanoplastics, and various bisphenol alternatives all show links to liver problems, suggesting that the full range of plastic pollutants -- not just BPA -- may pose a greater threat to liver health than previously understood.
Chronic Nanoplastic Exposure as a Novel Risk Amplifier for MASLD Progression
This study examines the potential for chronic nanoplastic exposure to amplify the progression of metabolic dysfunction-associated steatotic liver disease. The research explores how persistent nanoplastic exposure may act as a novel risk factor that worsens liver disease outcomes. The findings highlight growing concern about the intersection of plastic pollution and metabolic health conditions.
Adipose tissue as target of environmental toxicants: focus on mitochondrial dysfunction and oxidative inflammation in metabolic dysfunction-associated steatotic liver disease
This review examines how environmental toxicants, including micro and nanoplastics, target fat tissue and contribute to metabolic diseases like obesity, diabetes, and fatty liver disease. These pollutants disrupt mitochondria (the energy-producing parts of cells) and trigger a cycle of oxidative stress and inflammation that damages both fat tissue and the liver. The findings suggest that microplastic exposure could be one of several environmental factors contributing to the rising rates of metabolic disease worldwide.
Are Ingested or Inhaled Microplastics Involved in Nonalcoholic Fatty Liver Disease?
This review explored the potential connection between microplastic exposure through ingestion and inhalation and nonalcoholic fatty liver disease, which has become a leading cause of chronic liver injury. The study discusses how dietary and environmental microplastic exposure could potentially influence liver health through mechanisms including inflammation and endocrine disruption, though further research is needed to establish definitive links.
Examining the Pathogenesis of MAFLD and the Medicinal Properties of Natural Products from a Metabolic Perspective
This review examines the causes and potential treatments for metabolic-associated fatty liver disease (MAFLD), which affects about two-fifths of the global population. While focused on natural product remedies rather than microplastics, the metabolic pathways discussed, including lipid metabolism disruption and oxidative stress, are the same mechanisms through which microplastics have been shown to damage liver cells. Understanding these pathways helps explain how microplastic exposure could contribute to liver disease.
Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution
This review explores how environmental pollutants, including microplastics and endocrine-disrupting chemicals, may contribute to non-alcoholic fatty liver disease, with differences between men and women. The authors argue that diet and lifestyle changes alone cannot explain the rapid global rise in liver disease, and that chemical exposures deserve more attention. The study highlights how pollutants that disrupt hormones and metabolism could be an underrecognized factor in liver health.
Microplastics and nanoplastics: Emerging drivers of hepatic pathogenesis and metabolic dysfunction
This review examines emerging evidence linking micro- and nanoplastic exposure to liver disease, including metabolic dysfunction-associated liver disease, cirrhosis, and liver cancer. Researchers found that these particles may contribute to liver damage through oxidative stress, inflammation, and disruption of metabolic pathways. The study highlights the need for further research into how environmental plastic contamination may be influencing the rising rates of liver disease worldwide.
Biological exposure to microplastics and nanoplastics and plastic additives: impairment of glycolipid metabolism and adverse effects on metabolic diseases
This review examines how exposure to micro- and nanoplastics disrupts the body's ability to process sugars and fats, potentially contributing to diabetes, obesity, and atherosclerosis. The plastics cause inflammation and oxidative stress, damage gut bacteria, trigger insulin resistance, and increase fat buildup in the liver. For people who already have metabolic conditions, plastic exposure may make their disease worse.
Nanoplastics and MASLD : Unveiling Interorgan Crosstalk and Environmental Modulators
This brief editorial discusses the emerging connection between nanoplastic exposure and metabolic-associated steatotic liver disease (MASLD), a condition involving fat buildup in the liver. It highlights how nanoplastics may act as environmental triggers that affect the liver through interactions with the gut and other organs. As MASLD rates rise globally, understanding whether plastic pollution contributes to liver disease is an important emerging area of research.
Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions
This review summarizes what scientists know about how micro- and nanoplastics affect the liver, which is one of the first organs exposed because it processes everything absorbed from the gut. The particles trigger oxidative stress, disrupt energy metabolism, cause cell death, and promote inflammation, and may contribute to conditions like fatty liver disease and liver fibrosis. The paper also highlights how plastics can disturb the gut microbiome, which communicates with the liver through the gut-liver axis and may amplify liver damage.
Emerging threat of environmental microplastics: A comprehensive analysis of hepatic metabolic dysregulation and hepatocellular damage (Review)
This review summarizes existing research on how microplastics damage the liver, which is a key organ for filtering toxins from the body. Studies show that microplastics can cause liver tissue damage, trigger cell death, and disrupt fat metabolism, with smaller particles and longer exposure causing worse effects. The findings highlight the liver as a particularly vulnerable organ because it accumulates microplastics that enter the body through food and water.
Molecular LandscapeRemodeling Unravels the Cross-Linksof Microplastics-Induced Lipidomic Fluctuations,Nutrient Disorders and Energy Disarrangements
This study examined how polypropylene microplastics accumulate in and damage the mouse liver, using integrated lipidomics and transcriptomics to map the molecular landscape of microplastic-induced lipid disruption and metabolic dysfunction.
A review of environmental metabolism disrupting chemicals and effect biomarkers associating disease risks: Where exposomics meets metabolomics
This review examines how environmental chemicals, including contaminants associated with plastics, can disrupt human metabolism and contribute to conditions like obesity and diabetes. Researchers mapped the connections between chemical exposure and changes in metabolic biomarkers that signal disease risk. The study highlights the emerging field of metabolism-disrupting chemicals and the importance of understanding how everyday environmental exposures influence long-term metabolic health.
Microplastic pollution: A potent threat for metabolic disruption in mammals
This review examines the evidence linking microplastic exposure to metabolic disruption, covering mechanisms by which microplastics and their associated chemical additives may interfere with hormonal regulation, glucose metabolism, and lipid homeostasis. The authors identify microplastics as a potent emerging threat to metabolic health.
Non-parenchymal cells: key targets for modulating chronic liver diseases
This review examines how specialized non-parenchymal cells in the liver drive chronic liver diseases like fatty liver disease, fibrosis, and cirrhosis through inflammation and scarring. While not directly about microplastics, these are the same cell types and disease pathways that microplastics and nanoplastics have been shown to activate when they accumulate in liver tissue. Understanding these mechanisms helps explain how environmental pollutants like microplastics could contribute to the growing burden of chronic liver disease.
Molecular LandscapeRemodeling Unravels the Cross-Linksof Microplastics-Induced Lipidomic Fluctuations,Nutrient Disorders and Energy Disarrangements
This study assessed the liver toxicity of polypropylene microplastics in mice using combined lipidomics and transcriptomics, identifying disrupted lipid metabolism, altered cholesterol handling, and fibrotic tissue remodeling as key pathological outcomes.
Oral exposure to polyethylene microplastics induces inflammatory and metabolic changes and promotes fibrosis in mouse liver.
Mice fed polyethylene microplastics in their food for 6 to 9 weeks developed liver inflammation, metabolic disruption, oxidative stress, and increased cell growth in the liver. The microplastics also worsened liver scarring (fibrosis) when tested in mice with pre-existing liver damage. This is the first study to show that ingesting polyethylene, the most common type of plastic, can directly damage the mammalian liver and could worsen existing liver conditions.
Microplastics in focus: a silent disruptor of liver health- a systematic review
This systematic review examines how micro- and nanoplastics affect liver health, based on 25 experimental and observational studies. The evidence shows that polystyrene particles can cause liver inflammation, oxidative stress, fat buildup, and disruption of metabolic pathways. These findings are concerning because the liver is the body's primary detoxification organ, and plastic-related damage could impair its ability to process other toxins.
Microplastics, nanoplastics, and plastic chemicals: applying the key characteristics of metabolism disrupting agents shows reason for concern
Researchers applied the key characteristics framework for metabolism-disrupting agents to evaluate plastic-derived chemicals and micro- and nanoplastic particles. The study suggests that common plastic chemicals such as perfluorinated compounds and plastic particles themselves meet criteria associated with metabolic disruption, raising concerns about their potential role in metabolic diseases.
Molecular Landscape Remodeling Unravels the Cross-Links of Microplastics-Induced Lipidomic Fluctuations, Nutrient Disorders and Energy Disarrangements
Researchers fed mice polypropylene microplastics chronically and used lipidomics and transcriptomics to show that microplastics accumulated in the liver and disrupted lipid metabolism, cholesterol homeostasis, and redox balance, with high doses causing fibrotic liver changes.
Table 1_Microplastics in focus: a silent disruptor of liver health- a systematic review.docx
This systematic review of 25 studies found that micro- and nanoplastics can damage liver cells by causing oxidative stress, inflammation, and disrupting how the liver processes fats. These findings suggest that plastic particles small enough to reach the liver could contribute to liver disease, though more human studies are needed.