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61,005 resultsShowing papers similar to Potential threats of environmental microplastics to the skeletal system: current insights and future directions
ClearBridging relevance between microplastics, human health and bone metabolism: Emerging threats and research directions
Researchers reviewed how microplastics — tiny plastic fragments that accumulate in tissues throughout the body — may disrupt bone metabolism by triggering inflammation, oxidative stress, and hormonal interference, raising concern that widespread microplastic exposure could contribute to bone diseases like osteoporosis.
Effects of microplastics on the bones: a comprehensive review
This comprehensive review examines the growing evidence that micro- and nanoplastics can affect bone health, with researchers recently detecting plastic particles in human bone tissue for the first time. Lab studies show that microplastics can trigger inflammation, increase bone-resorbing cell activity, impair bone-forming cells, and weaken bone structure in animal models. While direct links to human bone conditions like osteoporosis have not yet been confirmed, the accumulating evidence suggests that microplastic exposure may represent a new risk factor for skeletal health.
Nanoplastic impact on bone microenvironment: A snapshot from murine bone cells.
Researchers investigated how nanoplastics affect the bone microenvironment using murine bone cell models, examining effects on osteoblast and osteoclast activity that regulate bone formation and resorption. Nanoplastic exposure disrupted bone cell function, raising concerns about skeletal health impacts from daily plastic particle exposure.
Nanoplastic impact on bone microenvironment: A snapshot from murine bone cells.
This study examined how nanoplastics affect bone cell function in a murine model, investigating effects on osteoblasts and osteoclasts that govern bone formation and resorption in the bone microenvironment. Nanoplastic exposure altered bone cell activity, suggesting that daily plastic particle exposure could have long-term implications for bone health.
Microplastics in human skeletal tissues: Presence, distribution and health implications
This study is the first to find microplastics in human bones, cartilage, and spinal discs, with the highest concentrations found in spinal discs. The most common plastics detected were polypropylene and polystyrene, and animal experiments confirmed that microplastics can reach skeletal tissues through the bloodstream. Exposure triggered inflammatory markers in the blood, suggesting microplastics in bones could contribute to skeletal health problems.
Microplastics in Musculoskeletal Disorders: An Emerging Threat
This review examines the emerging evidence that microplastics may affect the musculoskeletal system, including bones, cartilage, and muscles. Researchers found that microplastics can enter the body through ingestion, inhalation, and skin absorption, potentially triggering oxidative stress and inflammation in musculoskeletal tissues. The study suggests that more research is needed to understand the long-term impacts of microplastic exposure on bone and joint health.
[Effects of microplastics exposure in development of mineralized tissues].
This review examined evidence that microplastic exposure affects the formation and development of mineralized tissues including bone and teeth, finding that MP-induced oxidative stress and inflammation may disrupt mineralization processes and raise concern for skeletal health from environmental plastic exposure.
The Effects of Microplastics on Musculoskeletal Disorder; A Narrative Review
This review summarizes emerging research on how microplastics affect bones and muscles. Studies have shown that microplastics can disrupt the cells responsible for bone growth and repair, and in muscles they can reduce fiber density, impair blood vessel formation, and cause tissue wasting. While research is still limited, the findings suggest microplastics could contribute to musculoskeletal problems, and the authors call for more studies using human tissues.
Nanoplastic impact on bone microenvironment: A snapshot from murine bone cells
This study found that nanoplastics are toxic to bone cells in mice, causing cell death, increased production of damaging reactive oxygen species, and disruption of the bone remodeling process. The nanoplastics impaired the ability of bone-building cells to migrate and promoted the formation of bone-destroying cells. These findings suggest that nanoplastic exposure could potentially contribute to bone diseases like osteoporosis, though more research in living animals and humans is needed.
The silent invasion of microplastics polyvinyl chloride and polyethylene terephthalate: Potential impact on osteoporosis
Researchers detected microplastics in the blood samples of nearly all study participants and found that PVC and PET were the most common polymer types present. Through laboratory experiments, they demonstrated that these microplastics had significant toxic effects on bone-forming cells. The study suggests a potential link between microplastic exposure and bone health, indicating that further research is needed to understand how plastic particles in the bloodstream might affect skeletal health.
Unraveling the impact of nanoplastics on bone microenvironment: focus on extracellular vesicle-mediated communication and oxidative stress in multiple myeloma.
Researchers reviewed how nanoplastics affect the bone microenvironment, focusing on oxidative stress pathways and extracellular matrix disruption as key mechanisms of toxicity. Reactive oxygen species generated by nanoplastic exposure were identified as drivers of bone cell damage.
RANKL/OPG axis as a therapeutic target for microplastic-induced bone loss: Mechanistic insights from transcriptomic and functional validation
This study found microplastic deposits in human bone tissue and showed that MPs disrupt bone metabolism by altering the RANKL/OPG signaling axis, a key regulator of bone remodeling. Transcriptomic and functional analyses identified therapeutic target pathways that could potentially protect against microplastic-induced bone loss.
Unraveling the impact of nanoplastics on bone microenvironment: focus on extracellular vesicle-mediated communication and oxidative stress in multiple myeloma.
This study reviewed how nanoplastic particles disrupt the bone microenvironment through oxidative stress and damage to the extracellular matrix. Reactive oxygen species generated by nanoplastic exposure were found to drive toxicity in bone cells.
Polystyrene microplastics arrest skeletal growth in puberty through accelerating osteoblast senescence
Researchers found that polystyrene microplastics accumulated in the bones of mice during puberty, leading to reduced body and bone length and impaired bone structure. The microplastics accelerated premature aging (senescence) of bone-building cells called osteoblasts, suppressing their ability to form new bone. The study suggests that microplastic exposure during critical growth periods may pose a risk to skeletal development.
Discovery and analysis of microplastics in human bone marrow
For the first time, researchers detected microplastics in human bone marrow, finding plastic particles in all 16 samples tested. The most common types were polyethylene and polystyrene, with about 90% of particles smaller than 100 micrometers. This discovery shows that microplastics can penetrate deep into the body and reach the tissue where blood cells are made, raising questions about potential effects on blood cell production and immune function.
Plastics and their additives reached the blood and tissue spaces: what are the possible consequences?
This review examines how microplastics and their chemical additives reach human blood and tissue spaces and discusses the potential health consequences of this exposure. The authors synthesize evidence on pathways by which microplastics enter biological systems via food chains and direct environmental exposure, and assess the range of health effects being documented in humans and animals, noting the field is still relatively new with serious to very serious impacts being identified.
Micro(nano)plastics, an emerging health problem
This review frames micro- and nanoplastics as an emerging human health problem, synthesizing evidence of exposure routes, organ-level accumulation, and biological effects, and calling for updated regulatory frameworks to address this novel class of environmental contaminants.
Micro- and Nanoplastics on Human Health and Diseases: Perspectives and Recent Advances
This review provides a comprehensive overview of how micro- and nanoplastics enter the human body through ingestion, inhalation, and skin absorption, and how they can then travel through the bloodstream to reach virtually every organ. Researchers summarize evidence that these particles can trigger inflammation, oxidative stress, and disruption of hormonal and immune functions. The study emphasizes that the ability of these particles to cross biological barriers and accumulate in tissues makes understanding their long-term health effects an urgent research priority.
Impact of microplastics and nanoplastics on human Health: Emerging evidence and future directions
This review summarizes current evidence on how micro- and nanoplastics enter the human body through food, air, and skin contact, and the cellular damage they may cause. While microplastic pollution is a recognized environmental hazard, the authors note that definitive evidence linking plastic particle exposure to specific health outcomes in humans is still limited and more realistic exposure studies are needed.
Fatigue behaviour of load-bearing polymeric bone scaffolds: A review
This review examines how polymeric bone scaffolds used in tissue engineering perform under repeated mechanical stress, focusing on their fatigue behavior. While not directly about microplastics, the research is relevant because it explores how polymer materials break down under physical stress, which is similar to how plastic products degrade into microplastics in the environment. Understanding polymer fatigue helps explain why plastic materials fragment over time and contribute to micro- and nanoplastic pollution.
Effects of Polystyrene Microplastics on Bone-related Protein Expression, Mineralization Capacity, and Mitochondrial Function in Osteoblast-like Cells (mg-63)
Osteoblast-like cells (MG-63) were exposed to polystyrene microplastics at 5–50 µg/mL, and bone-related protein expression, mineralisation capacity, and mitochondrial function were assessed. PS-MPs were internalised and reduced mineralisation and osteocalcin levels while impairing mitochondrial bioenergetics, suggesting microplastics may negatively affect bone cell function.
Micro and nano-plastics, a threat to human health?
This review examines the threat micro- and nanoplastics pose to human health, discussing how these persistent particles accumulate in organs including lungs, the gastrointestinal system, and blood, and how their chemical composition and size influence toxicity.
Microplastics in Human Tissues: Sources, Distribution, Toxicological Effects, and Health Implications
Researchers reviewed the growing body of evidence that microplastics accumulate in human tissues — including lung, blood, placenta, breast milk, and heart tissue — where they can trigger inflammation, oxidative stress, and cell death. The review highlights urgent knowledge gaps around how plastic particles move through the body and what their long-term health effects may be.
A critical viewpoint on current issues, limitations, and future research needs on micro- and nanoplastic studies: From the detection to the toxicological assessment.
This critical review examines the current methods for detecting and characterizing micro- and nanoplastics in various environmental samples, as well as reported toxic effects from in vivo and in vitro studies. The authors found that while substantial effort has been made to understand microplastic behavior, the scientific community is still far from a complete understanding of how these particles behave in biological systems. The review calls for improved standardized protocols and more studies focused on uptake kinetics, accumulation, and biodistribution.