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20 resultsShowing papers similar to Analyzing the toxicological effects of PET-MPs on male infertility: Insights from network toxicology, mendelian randomization, and transcriptomics
ClearQuantitative analysis and toxicological mechanisms of various male infertility inducers: A network meta-analysis and pharmacological approach.
This network meta-analysis of 201 rodent studies compared nine common male infertility inducers, finding that microplastics caused among the most severe impairments to sperm count and motility — on par with the chemotherapy drug cyclophosphamide. Oxidative stress emerged as a shared mechanistic pathway across all inducers, pointing to it as a key target for understanding and potentially mitigating reproductive harm from environmental exposures.
Exploring the impact of polyethylene terephthalate nanoplastics on male reproductive health: Insights from a mouse model study
Researchers investigated the impact of polyethylene terephthalate nanoplastics on male reproductive health, examining whether nanoplastic exposure contributes to infertility by affecting sperm function, hormone levels, or testicular tissue. Results showed PET nanoplastics impaired reproductive endpoints in the male reproductive system, adding to growing concern about plastic particle effects on fertility.
Integrating multi-omics and network toxicology to identify FIS1 as a key target of environmental pollutants in male infertility
Researchers integrated blood transcriptomics, GWAS, and multi-omics data to identify FIS1 as a causal protective gene in male infertility, then used reverse network toxicology to predict six environmental pollutants—including DEHP and bisphenol S—that bind FIS1 and may disrupt mitochondrial function in sperm precursor cells.
Assessing the toxicological effects of exposure to environmental pollutants PET-MPs on vascular diseases: insights from network toxicology, molecular docking, molecular dynamics, and experimental validation
Researchers used network toxicology, molecular docking, and cell experiments to investigate how PET microplastics may contribute to vascular diseases. They identified four core molecular targets and found that PET microplastics induced mitochondrial oxidative stress, increased reactive oxygen species, and promoted vascular smooth muscle cell death. The study provides initial molecular-level evidence that microplastic exposure may be a contributing factor in vascular damage and remodeling.
Exploring the impact of polyethylene terephthalate nanoplastics on male reproductive health: Insights from a mouse model study
Researchers investigated the effects of PET nanoplastics on male reproductive function, examining sperm quality, hormone levels, and testicular tissue in animal models. PET nanoplastic exposure reduced sperm motility and caused histological changes in testicular tissue, suggesting a potential role in male infertility.
A meta-analysis-based adverse outcome pathway for the male reproductive toxicity induced by microplastics and nanoplastics in mammals
This meta-analysis of 39 studies mapped the adverse outcome pathway for microplastic and nanoplastic-induced male reproductive toxicity in mammals. Increased reactive oxygen species triggers a cascade of cellular damage including mitochondrial dysfunction, sperm DNA damage, and disrupted hormone signaling, ultimately leading to reduced sperm quality, impaired spermatogenesis, and decreased testosterone levels.
Reproductive and developmental implications of micro- and nanoplastic internalization: Recent advances and perspectives
This systematic review documented the detection of micro- and nanoplastics in human semen, placenta, and ovarian follicular fluid, and found evidence linking exposure to impaired sperm quality, disrupted ovarian function, and adverse pregnancy outcomes. In animal models, MNPs caused developmental toxicity and transgenerational effects, with oxidative stress, inflammation, and epigenetic modification identified as key mechanisms.
Reproductive toxicity and related mechanisms of micro(nano)plastics in terrestrial mammals: Review of current evidence.
This review of terrestrial mammal studies found that micro- and nanoplastics induce reproductive toxicity through oxidative stress, inflammation, endocrine disruption, and DNA damage, affecting both male and female fertility. In males, effects include blood-testis barrier disruption and impaired spermatogenesis, while females show compromised oocyte maturation, ovarian fibrosis, and diminished ovarian reserve, with particles also capable of crossing the maternal-fetal interface.
Testicular mitochondrial redox imbalance and impaired oxidative phosphorylation underlie microplastic-induced testicular dysfunction in Wistar rats
Researchers investigated how polyethylene microplastics affect male reproductive function in rats by examining testicular mitochondrial health. The study found that microplastic exposure disrupted mitochondrial redox balance and impaired oxidative phosphorylation in testicular tissue, providing mechanistic evidence for how microplastics may contribute to male reproductive toxicity.
Evaluating the toxicological effects of PET-MPs exposure on atherosclerosis through integrated network toxicology analysis and experimental validation
Researchers used network toxicology analysis and laboratory experiments to investigate how polyethylene terephthalate microplastics may contribute to atherosclerosis. They identified several molecular targets and biological pathways through which these microplastics could promote plaque formation in blood vessels. The study provides preliminary evidence that a commonly encountered type of microplastic may interact with cardiovascular disease mechanisms, though further research is needed to confirm these findings.
Network toxicology and bioinformatics analysis reveal the molecular mechanisms of polyethylene terephthalate microplastics in exacerbating diabetic nephropathy
This computational study used bioinformatics to explore how polyethylene terephthalate (PET) microplastics might worsen diabetic kidney disease. The analysis identified key genes and inflammatory pathways that are affected by both PET microplastics and kidney damage in diabetes. The findings suggest that microplastic exposure could accelerate kidney problems in people who already have diabetes, though lab and clinical studies are needed to confirm this.
Mechanistic study of plastic monomers in gestational diabetes mellitus: A network toxicology and molecular docking approach
Using network toxicology and molecular docking, researchers investigated how plastic monomers interact with molecular targets involved in gestational diabetes mellitus (GDM). The analysis identified shared gene targets and signaling pathways linking plastic monomer exposure to insulin resistance and inflammatory mechanisms relevant to GDM development.
The Threat of Micro-/Nanoplastics to Male Fertility: A Review of the Data and the Importance of Future Research
This review synthesizes findings from 21 studies examining how micro- and nanoplastics and their associated endocrine-disrupting chemicals affect male reproductive health at the cellular level. Researchers found evidence of multiple toxicity mechanisms including damage to the blood-testis barrier, disruption of hormone signaling, oxidative stress, and structural damage to testicular tissues. The study notes that while these findings from cell and animal studies are concerning, translating the results to human health requires further research with realistic exposure conditions.
A computational framework for multi-scale data fusion in assessing the associations between micro- and nanoplastics and human hepatotoxicity
Researchers developed a computational toxicology framework integrating multi-source data and network analysis to map associations between micro- and nanoplastics and hepatotoxicity, identifying key molecular pathways through which MNPs may damage the liver, offering a scalable alternative to traditional in vivo testing.
The impact of polyethylene terephthalate microplastics on the pathogenesis of atherosclerosis: Focusing on network toxicology and target gene detection
Researchers used network toxicology and gene analysis to investigate how PET microplastics may influence atherosclerosis, the buildup of plaque in arteries. They identified specific genes involved in inflammation and immune cell signaling that are affected by both PET exposure and atherosclerosis development. The study suggests that microplastic exposure could worsen cardiovascular disease through shared inflammatory pathways.
Integrative network toxicology and molecular docking preliminarily explore the potential role of polystyrene microplastics in childhood obesity
Researchers used an integrative computational approach combining cross-species transcriptomics, network toxicology, and molecular docking to investigate potential links between polystyrene microplastic exposure and childhood obesity. They identified shared gene targets involved in lipid metabolism and insulin signaling pathways, with molecular docking confirming stable binding between microplastic compounds and key metabolic proteins. The findings provide a preliminary molecular hypothesis suggesting microplastics could disrupt metabolic processes relevant to obesity.
Exploring the Potential Mechanism of Polyethylene Terephthalate Associated Cardiotoxicity through Network Toxicology and Molecular Docking
Researchers used computational approaches including network toxicology, molecular docking, and molecular dynamics simulations to explore how polyethylene terephthalate microplastics may affect cardiovascular function. The study identified potential molecular pathways through which PET exposure could contribute to cardiotoxicity. The findings provide a theoretical framework for understanding how plastic contaminants might interact with heart-related biological targets.
Microplastics and male reproductive system: A comprehensive review based on cellular and molecular effects
This comprehensive review examines how microplastics affect the male reproductive system at cellular and molecular levels, drawing on studies from multiple scientific databases. Researchers found that microplastics can damage testicular structure and function, impair spermatogenesis, and disrupt sperm parameters through mechanisms including oxidative stress, inflammation, and activation of cell death pathways. The review highlights that microplastics reduce ATP production and trigger signaling cascades that may contribute to male fertility problems.
Research Progress in Reproductive Toxicity of Micro- and Nanoplastics on Males and Its Mechanisms
This review summarized research on the reproductive toxicity of micro- and nanoplastics (MNPs) in males, finding that MNPs accumulate in reproductive organs and cause toxicity through oxidative stress, hormonal disruption, and DNA damage, with implications for both animal and human reproductive health.
Adverse outcome pathway networks of microplastic ecotoxicity to aquatic organisms: A critical review
Researchers used automated text-mining combined with multi-level ecotoxicological review to construct adverse outcome pathway networks for microplastic toxicity in aquatic organisms. They mapped how microplastics cause harm from initial tissue contact through molecular disturbances to higher-level biological effects in gills, gut, liver, gonads, and brain. The study found strong evidence for early-stage toxic mechanisms but identified critical knowledge gaps in understanding downstream biological consequences.